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Science 6 September 1996:
Vol. 273. no. 5280, pp. 1373 - 1377
DOI: 10.1126/science.273.5280.1373
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Reports

Antagonistic Interactions Between Wingless and Decapentaplegic Responsible for Dorsal-Ventral Pattern in the Drosophila Leg

William J. Brook and Stephen M. Cohen *

Subdivision of the limb primordia of Drosophila into anterior and posterior compartments triggers cell interactions that pattern the legs and wings. A comparable compartment-based mechanism is used to pattern the dorsal-ventral axis of the wing. Evidence is presented here for a mechanism based on cell interaction, rather than on compartment formation, that distinguishes dorsal from ventral in the leg. Mutual repression by Wingless and Decapentaplegic signaling systems generates a stable regulatory circuit by which each gene maintains its own expression in a spatially restricted domain. Compartment-independent patterning mechanisms may be used by other organisms during development.

European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany.
*   To whom correspondence should be addressed. E-mail: scohen{at}embl-heidelberg.de


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Role of dpp signalling in prepattern formation of the dorsocentral mechanosensory organ in Drosophila melanogaster.
Y Tomoyasu, M Nakamura, and N Ueno (1998)
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Generation of multiple antagonistic domains along the proximodistal axis during Drosophila leg development.
M Abu-Shaar and R. Mann (1998)
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slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development.
N. Theodosiou, S Zhang, W. Wang, and T Xu (1998)
Development 125, 3411-3416
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decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc.
D. Hazelett, M Bourouis, U Walldorf, and J. Treisman (1998)
Development 125, 3741-3751
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A molecular basis for transdetermination in Drosophila imaginal discs: interactions between wingless and decapentaplegic signaling.
L Maves and G Schubiger (1998)
Development 125, 115-124
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Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog.
J Royet and R Finkelstein (1997)
Development 124, 4793-4800
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Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis.
L O'Keefe, S. Dougan, L Gabay, E Raz, B. Shilo, and S DiNardo (1997)
Development 124, 4837-4845
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Different levels of Ras activity can specify distinct transcriptional and morphological consequences in early Drosophila embryos.
S Greenwood and G Struhl (1997)
Development 124, 4879-4886
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The roles of hedgehog and engrailed in patterning adult abdominal segments of Drosophila.
A Kopp, M. Muskavitch, and I Duncan (1997)
Development 124, 3703-3714
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Control of cell fate and polarity in the adult abdominal segments of Drosophila by optomotor-blind.
A Kopp and I Duncan (1997)
Development 124, 3715-3726
   Abstract »    PDF »
Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase.
K Weigmann, S. Cohen, and C. Lehner (1997)
Development 124, 3555-3563
   Abstract »    PDF »
Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen.
G Struhl, D. Barbash, and P. Lawrence (1997)
Development 124, 2143-2154
   Abstract »    PDF »
Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen.
G Struhl, D. Barbash, and P. Lawrence (1997)
Development 124, 2155-2165
   Abstract »    PDF »
Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm.
M Boyle, N Bonini, and S DiNardo (1997)
Development 124, 971-982
   Abstract »    PDF »
Shaggy and dishevelled exert opposite effects on Wingless and Decapentaplegic expression and on positional identity in imaginal discs.
T. Heslip, H Theisen, H Walker, and J. Marsh (1997)
Development 124, 1069-1078
   Abstract »    PDF »
Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing.
C. Neumann and S. Cohen (1997)
Development 124, 871-880
   Abstract »    PDF »
Role of decapentaplegic in initiation and progression of the morphogenetic furrow in the developing Drosophila retina.
F Chanut and U Heberlein (1997)
Development 124, 559-567
   Abstract »    PDF »
Developmental Control of Cell Cycle Regulators: A Fly's Perspective.
B. A. Edgar and C. F. Lehner (1996)
Science 274, 1646-1652
   Abstract »    Full Text »
A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing.
C. Neumann and S. Cohen (1996)
Development 122, 3477-3485
   Abstract »    PDF »
Notch signaling directly controls cell proliferation in the Drosophila wing disc.
A. Baonza and A. Garcia-Bellido (2000)
PNAS 97, 2609-2614
   Abstract »    Full Text »    PDF »


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