Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 August 1996:
Vol. 273. no. 5278, pp. 1056 - 1057
DOI: 10.1126/science.273.5278.1056
Prev | Table of Contents | Next

Perspectives

David Tollervey

Two recent reports, one in Cell and one in the Journal of Molecular Biology, show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of this rRNA modification.

The author is at the European Molecular Biology Laboratory, Postfach 10 22 09, Meyerhofstrasse, 69012 Heidelberg, Germany. E-mail: tollervey{at}embl-heidelberg.de


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation.
X. Zhang, E. A. Champion, E. J. Tran, B. A. Brown II, S. J. Baserga, and E. S. Maxwell (2006)
RNA 12, 1092-1103
   Abstract »    Full Text »    PDF »
Proteomic Analysis of Human Nop56p-associated Pre-ribosomal Ribonucleoprotein Complexes: POSSIBLE LINK BETWEEN Nop56p AND THE NUCLEOLAR PROTEIN TREACLE RESPONSIBLE FOR TREACHER COLLINS SYNDROME.
T. Hayano, M. Yanagida, Y. Yamauchi, T. Shinkawa, T. Isobe, and N. Takahashi (2003)
J. Biol. Chem. 278, 34309-34319
   Abstract »    Full Text »    PDF »
Enp1, a yeast protein associated with U3 and U14 snoRNAs, is required for pre-rRNA processing and 40S subunit synthesis.
W. Chen, J. Bucaria, D. A. Band, A. Sutton, and R. Sternglanz (2003)
Nucleic Acids Res. 31, 690-699
   Abstract »    Full Text »    PDF »
Naf1p, an Essential Nucleoplasmic Factor Specifically Required for Accumulation of Box H/ACA Small Nucleolar RNPs.
C. Dez, J. Noaillac-Depeyre, M. Caizergues-Ferrer, and Y. Henry (2002)
Mol. Cell. Biol. 22, 7053-7065
   Abstract »    Full Text »    PDF »
A novel gene organization: intronic snoRNA gene clusters from Oryza sativa.
D. Liang, H. Zhou, P. Zhang, Y.-Q. Chen, X. Chen, C.-L. Chen, and L.-H. Qu (2002)
Nucleic Acids Res. 30, 3262-3272
   Abstract »    Full Text »    PDF »
Endogenous and Silencing-Associated Small RNAs in Plants.
C. Llave, K. D. Kasschau, M. A. Rector, and J. C. Carrington (2002)
PLANT CELL 14, 1605-1619
   Abstract »    Full Text »    PDF »
The Schizosaccharomyces pombe mgU6-47 gene is required for 2'-O-methylation of U6 snRNA at A41.
H. Zhou, Y.-Q. Chen, Y.-P. Du, and L.-H. Qu (2002)
Nucleic Acids Res. 30, 894-902
   Abstract »    Full Text »    PDF »
Archaeal ribosomal protein L7 is a functional homolog of the eukaryotic 15.5kD/Snu13p snoRNP core protein.
J. F. Kuhn, E. J. Tran, and E. S. Maxwell (2002)
Nucleic Acids Res. 30, 931-941
   Abstract »    Full Text »    PDF »
Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana.
Q. Liang-Hu, M. Qing, Z. Hui, and C. Yue-Qin (2001)
Nucleic Acids Res. 29, 1623-1630
   Abstract »    Full Text »    PDF »
A Novel Helicase-Type Protein in the Nucleolus: Protein NOH61.
R. F. Zirwes, J. Eilbracht, S. Kneissel, and M. S. Schmidt-Zachmann (2000)
Mol. Biol. Cell 11, 1153-1167
   Abstract »    Full Text »
Box H and Box ACA Are Nucleolar Localization Elements of U17 Small Nucleolar RNA.
T. S. Lange, M. Ezrokhi, F. Amaldi, and S. A. Gerbi (1999)
Mol. Biol. Cell 10, 3877-3890
   Abstract »    Full Text »
Role of the Box C/D Motif in Localization of Small Nucleolar RNAs to Coiled Bodies and Nucleoli.
A. Narayanan, W. Speckmann, R. Terns, and M. P. Terns (1999)
Mol. Biol. Cell 10, 2131-2147
   Abstract »    Full Text »
Aspartate Transcarbamylase from the Hyperthermophilic Eubacterium Thermotoga maritima: Fused Catalytic and Regulatory Polypeptides Form an Allosteric Enzyme.
P. Chen, F. Van Vliet, M. Van De Casteele, C. Legrain, R. Cunin, and N. Glansdorff (1998)
J. Bacteriol. 180, 6389-6391
   Abstract »    Full Text »
The Putative Nucleic Acid Helicase Sen1p Is Required for Formation and Stability of Termini and for Maximal Rates of Synthesis and Levels of Accumulation of Small Nucleolar RNAs in Saccharomyces cerevisiae.
T. P. Rasmussen and M. R. Culbertson (1998)
Mol. Cell. Biol. 18, 6885-6896
   Abstract »    Full Text »
The box H+ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.
D. L.J. Lafontaine, C. Bousquet-Antonelli, Y. Henry, M. Caizergues-Ferrer, and D. Tollervey (1998)
Genes & Dev. 12, 527-537
   Abstract »    Full Text »
Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae.
V. Stolc and S. Altman (1997)
Genes & Dev. 11, 2926-2937
   Abstract »    Full Text »    PDF »
Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae.
V. Stolc and S. Altman (1997)
Genes & Dev. 11, 2414-2425
   Abstract »    Full Text »    PDF »
A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.
K. T. Tycowski, C. M. Smith, M.-D. Shu, and J. A. Steitz (1996)
PNAS 93, 14480-14485
   Abstract »    Full Text »    PDF »
Fibrillarin-associated Box C/D Small Nucleolar RNAs in Trypanosoma brucei. SEQUENCE CONSERVATION AND IMPLICATIONS FOR 2'-O-RIBOSE METHYLATION OF rRNA.
D. A. Dunbar, S. Wormsley, T. M. Lowe, and S. J. Baserga (2000)
J. Biol. Chem. 275, 14767-14776
   Abstract »    Full Text »    PDF »
Identities and Phylogenetic Comparisons of Posttranscriptional Modifications in 16 S Ribosomal RNA from Haloferax volcanii.
J. A. Kowalak, E. Bruenger, P. F. Crain, and J. A. McCloskey (2000)
J. Biol. Chem. 275, 24484-24489
   Abstract »    Full Text »    PDF »
Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing.
H. Wu, H. Xu, L. J. Miraglia, and S. T. Crooke (2000)
J. Biol. Chem. 275, 36957-36965
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)