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Science 16 August 1996:
Vol. 273. no. 5277, pp. 969 - 971
DOI: 10.1126/science.273.5277.969
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Reports

Cure of Short- and Long-Term Experimental Chagas' Disease Using D0870

Julio A. Urbina, * Gilberto Payares, Judith Molina, Cristina Sanoja, Andreína Liendo, Keyla Lazardi, Marta M. Piras, Romano Piras, Norma Perez, Patrick Wincker, John F. Ryley

Chagas' disease, a protozoan infection by the kinetoplastid Trypanosoma cruzi, constitutes a major public health problem in Latin America. With the use of mouse models of both short- and long-term forms of the disease, the efficacy of D0870, a bis-triazole derivative, was tested. D0870 was able to prevent death and induced parasitological cure in 70 to 90 percent of animals, in both the short- and long-term disease. In contrast, currently used drugs such as nifurtimox or ketoconazole prolonged survival but did not induce significant curing effects. D0870 may be useful in the treatment of human long-term Chagas' disease, a condition that is currently incurable.

J. A. Urbina, A. Liendo, K. Lazardi, N. Perez, Laboratorio de Química Biológica, Centro de Bioquímica y Biofísica, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020A, Venezuela.
G. Payares, J. Molina, C. Sanoja, Departamento de Parasitología, Instituto de Zoología Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Caracas 1040, Venezuela.
M. M. Piras and R. Piras, Unidad de Investigaciones, Centro Médico-Docente La Trinidad, Caracas 1080, Venezuela.
P. Wincker, Laboratoire `Genome des Parasites', Faculte de Medecine, Université de Montpellier, 163, rue Auguste Broussonet, 34000 Montpellier, France.
J. F. Ryley, 2 Wych Lane, Adlington, Macclesfield, Cheshire SK10 4NB, UK.
*   To whom correspondence should be addressed.


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