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Science 16 August 1996:
Vol. 273. no. 5277, pp. 923 - 0
DOI: 10.1126/science.273.5277.923
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Perspectives

Michael P. Conn, Cyril Y. Bowers

For a decade or so, there have been hints of an alternative way to regulate growth hormone beyond growth hormone-releasing hormone and somatostatin. Now Howard et al., in this week's Science (p. 974), have confirmed this suspicion by cloning the receptor for this alternative pathway. In their Perspective, Conn and Bowers discuss the unusual route by which this receptor was cloned, through the use of "reverse pharmacology" in which a synthetic ligand for the receptor was made before the natural ligand (which still remains unidentified).

P. M. Conn is with the Oregon Regional Primate Research Center, Beaverton, OR 97006-3499, USA, and in the Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, USA. E-mail: connm{at}ohsu.edu. C. Y. Bowers is in the Department of Medicine, Tulane Medical School, New Orleans, LA 70112, USA. E-mail: rjabower{at}tmcpop.tmc.tulane.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation.
R. Moreno-Reyes, M. Kerkhofs, M. L'Hermite-Baleriaux, M. O. Thorner, E. Van Cauter, and G. Copinschi (1998)
Am J Physiol Endocrinol Metab 274, E779-E784
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