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Science 9 August 1996:
Vol. 273. no. 5276, pp. 750 - 751
DOI: 10.1126/science.273.5276.750
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Perspectives

Stewart Leung, Xiaoxia Li, George R. Stark

A report in this week's issue of Science by Xu et al. ( p. 794) shows that homodimers of various kinds of STATs (signal transducers and activators of transcription) bind to regulatory regions of the gene for the interferon-gamma gene, each with a slightly different binding site. In their Perspective, Leung, Li, and Stark explain how these cooperating STAT dimers, which interact via their NH2 terminals, can determine the specificity of the cytokine response.

The authors are in the Department of Molecular Biology, Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. E-mail: starkg{at}cesmtp.ccf.org


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