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Science 5 July 1996:
Vol. 273. no. 5271, pp. 112 - 115
DOI: 10.1126/science.273.5271.112
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Reports

Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans

E. Jane Albert Hubbard, Qu Dong, Iva Greenwald *

The Caenorhabditis elegans LIN-12 and GLP-1 proteins are members of the LIN-12/Notch family of receptors for intercellular signals that specify cell fate. Evidence presented here suggests that the intracellular domains of LIN-12 and GLP-1 interact with the C. elegans EMB-5 protein and that the emb-5 gene functions in the same pathway as the lin-12 and glp-1 genes. EMB-5 is similar in sequence to a yeast protein that controls chromatin structure. Hence, a direct consequence of LIN-12 or GLP-1 activation may be an alteration of chromatin structure that produces changes in transcriptional activity.

E. J. A. Hubbard and Q. Dong, Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
I. Greenwald, Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
* To whom correspondence should be addressed. E-mail: greenwald{at}cuccfa.ccc.columbia.edu


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