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Science 28 June 1996:
Vol. 272. no. 5270, pp. 1904 - 0
DOI: 10.1126/science.272.5270.1904
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Perspectives

Rafi Ahmed

Viruses cause immediate induction of type I interferons (which include IFN-alpha and IFN-beta). These IFN I cytokines limit spread of the virus until antigen-specific responses can fully control the infection. A report by Tough et al. (p. 1947) show that these IFN I have another function: They also augment the proliferation of T cells, including a subset of T cells that may mediate long-term immunological memory. In his Perspective, Ahmed discusses the possible contribution of this bystander effect of IFN I to immunological memory.

The author is at the Emory Vaccine Center, Emory University School of Medicine, G211 Rollins Research Building, Atlanta, GA 30322, USA. E-mail: holcombe{at}microbio.emory.edu


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Science. ISSN 0036-8075 (print), 1095-9203 (online)