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Science 28 June 1996:
Vol. 272. no. 5270, pp. 1885 - 0
DOI: 10.1126/science.272.5270.1885
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Perspective

Robin A. Weiss

There are many ways of approaching research on AIDS, and sometimes different philosophies clash. Robin Weiss (Chester Beatty Laboratories, Institute of Cancer Research, UK) wryly portrays the differences between the experimentalists and the theorists as they try to understand how the interactions of HIV and its human host result in disease. He also presents his view that recent discoveries of cofactors for HIV entry highlight the improtance of a cell biology--centered approach to understanding pathogenesis.

The author is professor of viral oncology at the Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

Volume 272, Number 5270, Issue of 28 June 1996, pp. 1885-1885
©1996 by The American Association for the Advancement of Science.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
V3 Recombinants Indicate a Central Role for CCR5 as a Coreceptor in Tissue Infection by Human Immunodeficiency Virus Type 1.
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A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4.
A. McKnight, M. T. Dittmar, J. Moniz-Periera, K. Ariyoshi, J. D. Reeves, S. Hibbitts, D. Whitby, E. Aarons, A. E. I. Proudfoot, H. Whittle, et al. (1998)
J. Virol. 72, 4065-4071
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Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant.
C. Winkler, W. Modi, M. W. Smith, G. W. Nelson, X. Wu, M. Carrington, M. Dean, T. Honjo, K. Tashiro, D. Yabe, et al. (1998)
Science 279, 389-393
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Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression.
M. W. Smith, M. Dean, M. Carrington, C. Winkler, G. A. Huttley, D. A. Lomb, J. J. Goedert, T. R. O'Brien, L. P. Jacobson, R. Kaslow, et al. (1997)
Science 277, 959-965
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Sexual Transmission of HIV.
R. A. Royce, A. Sena, W. Cates, and M. S. Cohen (1997)
N. Engl. J. Med. 336, 1072-1078
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Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection.
P. Klenerman, R. E. Phillips, C. R. Rinaldo, L. M. Wahl, G. Ogg, R. M. May, A. J. McMichael, and M. A. Nowak (1996)
PNAS 93, 15323-15328
   Abstract »    Full Text »    PDF »
Response: HIV-1 Evolution and Disease Progression.
S. M. Wolinsky, K. J. Kunstman, J. T. Safrit, R. A. Koup, A. U. Neumann, and B. T. M. Korber (1996)
Science 274, 1010-1011
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Science. ISSN 0036-8075 (print), 1095-9203 (online)