Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Applied Bio

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 June 1996:
Vol. 272. no. 5267, pp. 1492 - 1494
DOI: 10.1126/science.272.5267.1492
Prev | Table of Contents | Next

Reports

Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation

Thottala Jayaraman, Karol Ondrias, Elena Ondriasová, Andrew R. Marks *

Tyrosine kinases indirectly raise intracellular calcium concentration ([Ca2+]i) by activating phospholipases that generate inositol 1,4,5-trisphosphate (IP3). IP3 activates the IP3 receptor (IP3R), an intracellular calcium release channel on the endoplasmic reticulum. T cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP3R, which induced tyrosine phosphorylation of the IP3R. Fyn activated an IP3-gated calcium channel in vitro, and tyrosine phosphorylation of the IP3R during T cell activation was reduced in thymocytes from fyn-/- mice. Thus, activation of the IP3R by tyrosine phosphorylation may play a role in regulating [Ca2+]i.

Laboratory for Molecular Cardiology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of the Inositol 1,4,5-Trisphosphate Receptor Type I by O-GlcNAc Glycosylation.
J. Rengifo, C. J. Gibson, E. Winkler, T. Collin, and B. E. Ehrlich (2007)
J. Neurosci. 27, 13813-13821
   Abstract »    Full Text »    PDF »
A function for tyrosine phosphorylation of type 1 inositol 1,4,5-trisphosphate receptor in lymphocyte activation.
N. deSouza, J. Cui, M. Dura, T. V. McDonald, and A. R. Marks (2007)
J. Cell Biol. 179, 923-934
   Abstract »    Full Text »    PDF »
The Calponin Homology Domain of Vav1 Associates with Calmodulin and Is Prerequisite to T Cell Antigen Receptor-induced Calcium Release in Jurkat T Lymphocytes.
Z. Zhou, J. Yin, Z. Dou, J. Tang, C. Zhang, and Y. Cao (2007)
J. Biol. Chem. 282, 23737-23744
   Abstract »    Full Text »    PDF »
Molecular basis for PP2A regulatory subunit B56{alpha} targeting in cardiomyocytes.
N. Bhasin, S. R. Cunha, M. Mudannayake, M. S. Gigena, T. B. Rogers, and P. J. Mohler (2007)
Am J Physiol Heart Circ Physiol 293, H109-H119
   Abstract »    Full Text »    PDF »
Molecular and Functional Characterization of Inositol Trisphosphate Receptors during Early Zebrafish Development.
R. Ashworth, B. Devogelaere, J. Fabes, R. E. Tunwell, K. R. Koh, H. De Smedt, and S. Patel (2007)
J. Biol. Chem. 282, 13984-13993
   Abstract »    Full Text »    PDF »
Inositol Trisphosphate Receptor Ca2+ Release Channels.
J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak (2007)
Physiol Rev 87, 593-658
   Abstract »    Full Text »    PDF »
PAG-Associated FynT Regulates Calcium Signaling and Promotes Anergy in T Lymphocytes.
D. Davidson, B. Schraven, and A. Veillette (2007)
Mol. Cell. Biol. 27, 1960-1973
   Abstract »    Full Text »    PDF »
The Inositol 1,4,5-Trisphosphate Receptor (IP3R) and Its Regulators: Sometimes Good and Sometimes Bad Teamwork.
C.-u. Choe and B. E. Ehrlich (2006)
Sci. STKE 2006, re15
   Abstract »    Full Text »    PDF »
Phosphorylation of IP3R1 and the regulation of [Ca2+]i responses at fertilization: a role for the MAP kinase pathway.
B. Lee, E. Vermassen, S.-Y. Yoon, V. Vanderheyden, J. Ito, D. Alfandari, H. De Smedt, J. B. Parys, and R. A. Fissore (2006)
Development 133, 4355-4365
   Abstract »    Full Text »    PDF »
Pregnancy-enhanced store-operated Ca2+ channel function in uterine artery endothelial cells is associated with enhanced agonist-specific transient receptor potential channel 3-inositol 1,4,5-trisphosphate receptor 2 interaction..
S. M Gifford, F.-X. Yi, and I. M Bird (2006)
J. Endocrinol. 190, 385-395
   Abstract »    Full Text »    PDF »
Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation.
F. Zhong, M. C. Davis, K. S. McColl, and C. W. Distelhorst (2006)
J. Cell Biol. 172, 127-137
   Abstract »    Full Text »    PDF »
Cdc2/Cyclin B1 Interacts with and Modulates Inositol 1,4,5-Trisphosphate Receptor (Type 1) Functions.
X. Li, K. Malathi, O. Krizanova, K. Ondrias, K. Sperber, V. Ablamunits, and T. Jayaraman (2005)
J. Immunol. 175, 6205-6210
   Abstract »    Full Text »    PDF »
The 1,4,5-inositol trisphosphate pathway is a key component in Fas-mediated hypertrophy in neonatal rat ventricular myocytes.
Y. D. Barac, N. Zeevi-Levin, G. Yaniv, I. Reiter, F. Milman, M. Shilkrut, R. Coleman, Z. Abassi, and O. Binah (2005)
Cardiovasc Res 68, 75-86
   Abstract »    Full Text »    PDF »
Na/K-ATPase Tethers Phospholipase C and IP3 Receptor into a Calcium-regulatory Complex.
Z. Yuan, T. Cai, J. Tian, A. V. Ivanov, D. R. Giovannucci, and Z. Xie (2005)
Mol. Biol. Cell 16, 4034-4045
   Abstract »    Full Text »    PDF »
Mechanism of Bradykinin-Induced Ca2+ Mobilization in Murine Proximal Tubule Epithelial Cells.
M. M. Tiwari, P. L. Prather, and P. R. Mayeux (2005)
J. Pharmacol. Exp. Ther. 313, 798-805
   Abstract »    Full Text »    PDF »
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation.
C. E. Zielinski, S. N. Jacob, F. Bouzahzah, B. E. Ehrlich, and J. Craft (2005)
J. Immunol. 174, 5100-5109
   Abstract »    Full Text »    PDF »
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons.
A. Verkhratsky (2005)
Physiol Rev 85, 201-279
   Abstract »    Full Text »    PDF »
Growth Hormone Promotes Ca2+-Induced Ca2+ Release in Insulin-Secreting Cells by Ryanodine Receptor Tyrosine Phosphorylation.
Q. Zhang, M. Kohler, S.-N. Yang, F. Zhang, O. Larsson, and P.-O. Berggren (2004)
Mol. Endocrinol. 18, 1658-1669
   Abstract »    Full Text »    PDF »
Effect of tyrosine kinase blockade on norepinephrine-induced cytosolic calcium response in rat afferent arterioles.
M. Salomonsson and W. J. Arendshorst (2004)
Am J Physiol Renal Physiol 286, F866-F874
   Abstract »    Full Text »    PDF »
Regulation of the Type 1 Inositol 1,4,5-Trisphosphate Receptor by Phosphorylation at Tyrosine 353.
J. Cui, S. J. Matkovich, N. deSouza, S. Li, N. Rosemblit, and A. R. Marks (2004)
J. Biol. Chem. 279, 16311-16316
   Abstract »    Full Text »    PDF »
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
A. Macdonald, K. Crowder, A. Street, C. McCormick, and M. Harris (2004)
J. Gen. Virol. 85, 721-729
   Abstract »    Full Text »    PDF »
Modulation of Histamine-induced Ca2+ Release by Protein Kinase C: EFFECTS ON CYTOSOLIC AND MITOCHONDRIAL [Ca2+] PEAKS.
M. Montero, C. D. Lobaton, S. Gutierrez-Fernandez, A. Moreno, and J. Alvarez (2003)
J. Biol. Chem. 278, 49972-49979
   Abstract »    Full Text »    PDF »
Phosphorylation of Type-1 Inositol 1,4,5-Trisphosphate Receptors by Cyclic Nucleotide-dependent Protein Kinases: A MUTATIONAL ANALYSIS OF THE FUNCTIONALLY IMPORTANT SITES IN THE S2+ AND S2- SPLICE VARIANTS.
L. E. Wagner II, W.-H. Li, and D. I. Yule (2003)
J. Biol. Chem. 278, 45811-45817
   Abstract »    Full Text »    PDF »
Crucial Role of Type 2 Inositol 1,4,5-Trisphosphate Receptors for Acetylcholine-Induced Ca2+ Oscillations in Vascular Myocytes.
J.-L. Morel, N. Fritz, J.-L. Lavie, and J. Mironneau (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 1567-1575
   Abstract »    Full Text »    PDF »
Increased Endothelin-Induced Ca2+ Signaling, Tyrosine Phosphorylation, and Coronary Artery Disease in Diabetic Dyslipidemic Swine Are Prevented by Atorvastatin.
D. L. Lee, B. R. Wamhoff, L. C. Katwa, H. K. Reddy, D. J. Voelker, J. L. Dixon, and M. Sturek (2003)
J. Pharmacol. Exp. Ther. 306, 132-140
   Abstract »    Full Text »    PDF »
IRBIT, a Novel Inositol 1,4,5-Trisphosphate (IP3) Receptor-binding Protein, Is Released from the IP3 Receptor upon IP3 Binding to the Receptor.
H. Ando, A. Mizutani, T. Matsu-ura, and K. Mikoshiba (2003)
J. Biol. Chem. 278, 10602-10612
   Abstract »    Full Text »    PDF »
Protein Kinase A and Two Phosphatases Are Components of the Inositol 1,4,5-Trisphosphate Receptor Macromolecular Signaling Complex.
N. deSouza, S. Reiken, K. Ondrias, Y.-m. Yang, S. Matkovich, and A. R. Marks (2002)
J. Biol. Chem. 277, 39397-39400
   Abstract »    Full Text »    PDF »
The Inhibitory Influence of Endothelin on Active Sodium-Potassium Transport in Porcine Lens.
M. C. Okafor and N. A. Delamere (2001)
Invest. Ophthalmol. Vis. Sci. 42, 1018-1023
   Abstract »    Full Text »
Cross Talk Between Cyclic Nucleotides and Polyphosphoinositide Hydrolysis, Protein Kinases, and Contraction in Smooth Muscle.
A. A. Abdel-Latif (2001)
Experimental Biology and Medicine 226, 153-163
   Abstract »    Full Text »
Negative Control of Store-Operated Ca2+ Influx by B Cell Receptor Cross-Linking.
A. Hashimoto, K. Hirose, T. Kurosaki, and M. Iino (2001)
J. Immunol. 166, 1003-1008
   Abstract »    Full Text »    PDF »
EGF inhibits muscarinic receptor-mediated calcium signaling in a human salivary cell line.
B.-X. Zhang, C.-K. Yeh, T. K. Hymer, M. D. Lifschitz, and M. S. Katz (2000)
Am J Physiol Cell Physiol 279, C1024-C1033
   Abstract »    Full Text »    PDF »
Cardiac Intracellular Calcium Release Channels : Role in Heart Failure.
A. R. Marks (2000)
Circ. Res. 87, 8-11
   Full Text »    PDF »
Tyrosine kinase-dependent calcium signaling in airway smooth muscle cells.
B. Tolloczko, F. C. Tao, M. E. Zacour, and J. G. Martin (2000)
Am J Physiol Lung Cell Mol Physiol 278, L1138-L1145
   Abstract »    Full Text »    PDF »
The HIV Nef Protein Alters Ca2+ Signaling in Myelomonocytic Cells through SH3-mediated Protein-Protein Interactions.
M. Foti, L. Cartier, V. Piguet, D. P. Lew, J.-L. Carpentier, D. Trono, and K.-H. Krause (1999)
J. Biol. Chem. 274, 34765-34772
   Abstract »    Full Text »    PDF »
Direct Interaction in T-cells between theta PKC and the Tyrosine Kinase p59fyn.
D. Ron, E. W. Napolitano, A. Voronova, N. J. Vasquez, D. N. Roberts, B. L. Calio, R. H. Caothien, S. M. Pettiford, S. Wellik, J. B. Mandac, et al. (1999)
J. Biol. Chem. 274, 19003-19010
   Abstract »    Full Text »    PDF »
Src Promotes PKC{{delta}} Degradation.
R. A. Blake, P. Garcia-Paramio, P. J. Parker, and S. A. Courtneidge (1999)
Cell Growth Differ. 10, 231-241
   Abstract »    Full Text »
Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor by Cyclic Nucleotide-dependent Kinases in Vitro and in Rat Cerebellar Slices in Situ.
L. S. Haug, V. Jensen, O. Hvalby, S. I. Walaas, and A. C. Ostvold (1999)
J. Biol. Chem. 274, 7467-7473
   Abstract »    Full Text »    PDF »
Uncoupling Activation-Dependent HS1 Phosphorylation from Nuclear Factor of Activated T Cells Transcriptional Activation in Jurkat T Cells: Differential Signaling Through CD3 and the Costimulatory Receptors CD2 and CD28.
J. E. Hutchcroft, J. M. Slavik, H. Lin, T. Watanabe, and B. E. Bierer (1998)
J. Immunol. 161, 4506-4512
   Abstract »    Full Text »    PDF »
Cytosolic Free Calcium and the Cytoskeleton in the Control of Leukocyte Chemotaxis.
E. J. PETTIT (1998)
Physiol Rev 78, 949-967
   Abstract »    Full Text »    PDF »
Interaction of p59fyn Kinase with the Dynein Light Chain, Tctex-1, and Colocalization During Cytokinesis.
K. S. Campbell, S. Cooper, M. Dessing, S. Yates, and A. Buder (1998)
J. Immunol. 161, 1728-1737
   Abstract »    Full Text »    PDF »
V7 (CD101) Ligation Inhibits TCR/CD3-Induced IL-2 Production by Blocking Ca2+ Flux and Nuclear Factor of Activated T Cell Nuclear Translocation.
L. R. B. Soares, L. Tsavaler, A. Rivas, and E. G. Engleman (1998)
J. Immunol. 161, 209-217
   Abstract »    Full Text »    PDF »
Role of Tyrosine Kinase in Dilator Responses of Rat Basilar Artery In Vivo.
T. Kitazono, S. Ibayashi, T. Nagao, K. Fujii, T. Kagiyama, and M. Fujishima (1998)
Hypertension 31, 861-865
   Abstract »    Full Text »    PDF »
Nongenomic Actions of Steroid Hormones in Reproductive Tissues.
A. Revelli, M. Massobrio, and J. Tesarik (1998)
Endocr. Rev. 19, 3-17
   Abstract »    Full Text »
Syk and Fyn Are Required by Mouse Megakaryocytes for the Rise in Intracellular Calcium Induced by a Collagen-related Peptide.
S. K. Melford, M. Turner, S. J. Briddon, V. L. J. Tybulewicz, and S. P. Watson (1997)
J. Biol. Chem. 272, 27539-27542
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation Modulates Current Amplitude and Kinetics of a Neuronal Voltage-Gated Potassium Channel.
D. A. Fadool, T. C. Holmes, K. Berman, D. Dagan, and I. B. Levitan (1997)
J Neurophysiol 78, 1563-1573
   Abstract »    Full Text »    PDF »
Regulation of Platelet Plasma Membrane Ca2+-ATPase by cAMP-dependent and Tyrosine Phosphorylation.
W. L. Dean, D. Chen, P. C. Brandt, and T. C. Vanaman (1997)
J. Biol. Chem. 272, 15113-15119
   Abstract »    Full Text »    PDF »
Defective Signaling to Fyn by a T Cell Antigen Receptor Lacking the alpha -Chain Connecting Peptide Motif.
C. Ulivieri, A. Peter, E. Orsini, E. Palmer, and C. T. Baldari (2001)
J. Biol. Chem. 276, 3574-3580
   Abstract »    Full Text »    PDF »
Transient Tyrosine Phosphorylation of Human Ryanodine Receptor upon T Cell Stimulation.
A. H. Guse, A. Y. Tsygankov, K. Weber, and G. W. Mayr (2001)
J. Biol. Chem. 276, 34722-34727
   Abstract »    Full Text »    PDF »
HIV-1 Nef Interacts with Inositol Trisphosphate Receptor to Activate Calcium Signaling in T Cells.
A. Manninen and K. Saksela (2002)
J. Exp. Med. 195, 1023-1032
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)