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Science 7 June 1996:
Vol. 272. no. 5267, pp. 1484 - 1486
DOI: 10.1126/science.272.5267.1484
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Reports

Structural Evidence for Functional Domains in the Rat Hippocampus

P. Y. Risold and L. W. Swanson *

The hippocampus has two major outputs: multisynaptic pathways to the cerebral cortex and a massive descending projection directly to the lateral septal part of the basal ganglia. Here it is shown that the descending output is organized in such a way that different hippocampal regions map in an orderly way onto hypothalamic systems mediating the expression of different classes of goal-oriented behavior. This mapping is characterized by a unidirectional hippocampo-lateral septal projection and then by bidirectional lateral septo-hypothalamic projections, all topographically organized. The connectional evidence predicts that information processing in different regions of the hippocampus selectively influences the expression of different classes of behavior.

Program in Neural, Informational, and Behavioral Sciences and the Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1.
H.-W. Dong, L. W. Swanson, L. Chen, M. S. Fanselow, and A. W. Toga (2009)
PNAS 106, 11794-11799
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Finite Scale of Spatial Representation in the Hippocampus.
K. B. Kjelstrup, T. Solstad, V. H. Brun, T. Hafting, S. Leutgeb, M. P. Witter, E. I. Moser, and M.-B. Moser (2008)
Science 321, 140-143
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Topography of Arc/Arg3.1 mRNA Expression in the Dorsal and Ventral Hippocampus Induced by Recent and Remote Spatial Memory Recall: Dissociation of CA3 and CA1 Activation.
P. A. Gusev, C. Cui, D. L. Alkon, and A. N. Gubin (2005)
J. Neurosci. 25, 9384-9397
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Neurocircuitry of Stress Integration: Anatomical Pathways Regulating the Hypothalamo-Pituitary-Adrenocortical Axis of the Rat.
D. R. Ziegler and J. P. Herman (2002)
Integr. Comp. Biol. 42, 541-551
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Differential Effects of Dorsal and Ventral Hippocampal Lesions.
B. J. Hock Jr. and M. D. Bunsey (1998)
J. Neurosci. 18, 7027-7032
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Giant Depolarizing Potentials: the Septal Pole of the Hippocampus Paces the Activity of the Developing Intact Septohippocampal Complex In Vitro.
X. Leinekugel, I. Khalilov, Y. Ben-Ari, and R. Khazipov (1998)
J. Neurosci. 18, 6349-6357
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Region-Specific Regulation of Glutamic Acid Decarboxylase (GAD) mRNA Expression in Central Stress Circuits.
G. Bowers, W. E. Cullinan, and J. P. Herman (1998)
J. Neurosci. 18, 5938-5947
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Differential Patterns of c-fos mRNA Expression in Amygdala During Successive Stages of Odor Discrimination Learning.
U. S. Hess, C. M. Gall, R. Granger, and G. Lynch (1997)
Learn. Mem. 4, 262-283
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