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Science 7 June 1996:
Vol. 272. no. 5267, pp. 1397 - 0
DOI:

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Chemicals in the environment that act like natural estrogens have been suspected to have the potential to disrupt normal reproductive function of exposed organisms. However, these compounds are much less potent than natural estrogens. Arnold et al. (p. 1489; see the Perspective by Simmons, p. 1451, and the news story by Kaiser, p. 1418) tested the effects of combinations of two environmental estrogens on binding and activation of the estrogen receptor. Combinations of the compounds were 10 to 1600 times more potent than the individual compounds in activating estrogen receptor-mediated transcription. The synergistic biological activity of the compounds reflected synergistic binding to the estrogen receptor.




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