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Science 31 May 1996:
Vol. 272. no. 5266, pp. 1336 - 1339
DOI: 10.1126/science.272.5266.1336
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Reports

An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors

Wongi Seol, * Hueng-Sik Choi, *dagger David D. Moore ddagger

SHP is an orphan member of the nuclear hormone receptor superfamily that contains the dimerization and ligand-binding domain found in other family members but lacks the conserved DNA binding domain. In the yeast two-hybrid system, SHP interacted with several conventional and orphan members of the receptor superfamily, including retinoid receptors, the thyroid hormone receptor, and the orphan receptor MB67. SHP also interacted directly with these receptors in vitro. In mammalian cells, SHP specifically inhibited transactivation by the superfamily members with which it interacted. These results suggest that SHP functions as a negative regulator of receptor-dependent signaling pathways.

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
* These authors contributed equally to this work.
dagger Present address: Hormone Research Center, Department of Biology, Chonnam National University, Kwangju, Republic of Korea 500-757.
ddagger To whom correspondence should be addressed.


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   Abstract »    Full Text »    PDF »
Loss of HNF-1{alpha} Function in Mice Leads to Abnormal Expression of Genes Involved in Pancreatic Islet Development and Metabolism.
D. Q. Shih, S. Screenan, K. N. Munoz, L. Philipson, M. Pontoglio, M. Yaniv, K. S. Polonsky, and M. Stoffel (2001)
Diabetes 50, 2472-2480
   Abstract »    Full Text »    PDF »
Suppression of sterol 12{alpha}-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism.
A. del Castillo-Olivares and G. Gil (2001)
Nucleic Acids Res. 29, 4035-4042
   Abstract »    Full Text »    PDF »
Mechanisms of Estrogen Action.
S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-A. Gustafsson (2001)
Physiol Rev 81, 1535-1565
   Abstract »    Full Text »    PDF »
Nuclear Hormone Receptors and Gene Expression.
A. Aranda and A. Pascual (2001)
Physiol Rev 81, 1269-1304
   Abstract »    Full Text »    PDF »
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.
H. Nishigori, H. Tomura, N. Tonooka, M. Kanamori, S. Yamada, K. Sho, I. Inoue, N. Kikuchi, K. Onigata, I. Kojima, et al. (2000)
PNAS
   Abstract »    Full Text »
Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers.
J. J. Repa, S. D. Turley, J.-M. A. Lobaccaro, J. Medina, L. Li, K. Lustig, B. Shan, R. A. Heyman, J. M. Dietschy, and D. J. Mangelsdorf (2000)
Science 289, 1524-1529
   Abstract »    Full Text »
Truncated Estrogen Receptor Product-1 Suppresses Estrogen Receptor Transactivation by Dimerization with Estrogen Receptors alpha and beta.
E. M. Resnick, D. A. Schreihofer, A. Periasamy, and M. A. Shupnik (2000)
J. Biol. Chem. 275, 7158-7166
   Abstract »    Full Text »    PDF »
Synergy of SF1 and RAR in Activation of Oct-3/4 Promoter.
E. Barnea and Y. Bergman (2000)
J. Biol. Chem. 275, 6608-6619
   Abstract »    Full Text »    PDF »
The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors.
L. Johansson, A. Båvner, J. S. Thomsen, M. Färnegårdh, J.-A. Gustafsson, and E. Treuter (2000)
Mol. Cell. Biol. 20, 1124-1133
   Abstract »    Full Text »
The Orphan Nuclear Receptor SHP Inhibits Hepatocyte Nuclear Factor 4 and Retinoid X Receptor Transactivation: Two Mechanisms for Repression.
Y.-K. Lee, H. Dell, D. H. Dowhan, M. Hadzopoulou-Cladaras, and D. D. Moore (2000)
Mol. Cell. Biol. 20, 187-195
   Abstract »    Full Text »
Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: A unique signaling pathway in the steroid receptor superfamily.
Y.-F. Lee, C.-R. Shyr, T. H. Thin, W.-J. Lin, and C. Chang (1999)
PNAS 96, 14724-14729
   Abstract »    Full Text »    PDF »
Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors alpha and beta.
C.-y. Chang, J. D. Norris, H. Gron, L. A. Paige, P. T. Hamilton, D. J. Kenan, D. Fowlkes, and D. P. McDonnell (1999)
Mol. Cell. Biol. 19, 8226-8239
   Abstract »    Full Text »    PDF »
Orphan Nuclear Receptors: From Gene to Function.
V. Giguère (1999)
Endocr. Rev. 20, 689-725
   Abstract »    Full Text »
Activation of the Promoter of the Orphan Receptor SHP by Orphan Receptors That Bind DNA as Monomers.
Y.-K. Lee, K. L. Parker, H.-S. Choi, and D. D. Moore (1999)
J. Biol. Chem. 274, 20869-20873
   Abstract »    Full Text »    PDF »
The Autonomous Transactivation Domain in Helix H3 of the Vitamin D Receptor Is Required For Transactivation and Coactivator Interaction.
D. M. Kraichely, J. J. Collins III, R. K. DeLisle, and P. N. MacDonald (1999)
J. Biol. Chem. 274, 14352-14358
   Abstract »    Full Text »    PDF »
Transcriptional Regulation by a Naturally Occurring Truncated Rat Estrogen Receptor (ER), Truncated ER Product-1 (TERP-1).
D. A. Schreihofer, E. M. Resnick, A. Y. Soh, and M. A. Shupnik (1999)
Mol. Endocrinol. 13, 320-329
   Abstract »    Full Text »
The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERalpha and ERbeta.
L. Johansson, J. S. Thomsen, A. E. Damdimopoulos, G. Spyrou, J.-A. Gustafsson, and E. Treuter (1999)
J. Biol. Chem. 274, 345-353
   Abstract »    Full Text »    PDF »
Three Isoforms of a Hepatocyte Nuclear Factor-4 Transcription Factor with Tissue- and Stage-specific Expression in the Adult Mosquito.
M. Z. Kapitskaya, N. T. Dittmer, K. W. Deitsch, W.-L. Cho, D. G. Taylor, T. Leff, and A. S. Raikhel (1998)
J. Biol. Chem. 273, 29801-29810
   Abstract »    Full Text »    PDF »
The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene.
P. Honkakoski, I. Zelko, T. Sueyoshi, and M. Negishi (1998)
Mol. Cell. Biol. 18, 5652-5658
   Abstract »    Full Text »
Inhibition of Estrogen Receptor Action by the Orphan Receptor SHP (Short Heterodimer Partner).
W. Seol, B. Hanstein, M. Brown, and D. D. Moore (1998)
Mol. Endocrinol. 12, 1551-1557
   Abstract »    Full Text »
Estrogen Receptor, a Common Interaction Partner for a Subset of Nuclear Receptors.
S.-K. Lee, H.-S. Choi, M.-R. Song, M.-O. Lee, and J. W. Lee (1998)
Mol. Endocrinol. 12, 1184-1192
   Abstract »    Full Text »


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