Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 17 May 1996:
Vol. 272. no. 5264, pp. 954 - 0
DOI: 10.1126/science.272.5264.954
|
|
Research News
Trisha Gura
The proteins known as chemokines achieved public fame late last year, as a result of work suggesting that they might help protect against AIDS. But the proteins have a much wider role than that. As magnets for white blood cells, they play a key role in in
flammatory responses and thus in the body's defenses against a wide array of invading pathogens. What's more, chemokine effects can also backfire, and contribute to a wide range of inflammatory diseases, such as rheumatoid arthritis, asthma, and adult res
piratory distress syndrome, a major killer characterized by fluid buildup in the lungs. As a result, the chemokines have become major targets of efforts to develop new anti-inflammatory therapies, and recent work is already producing some promising result
s.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Protein Kinase C{alpha}-RhoA Cross-talk in CCL2-induced Alterations in Brain Endothelial Permeability.
- S. M. Stamatovic, O. B. Dimitrijevic, R. F. Keep, and A. V. Andjelkovic (2006)
J. Biol. Chem.
281, 8379-8388
| Abstract »
| Full Text »
| PDF »
- Chemokines, innate and adaptive immunity, and respiratory disease.
- I. Sabroe, C.M. Lloyd, M.K.B. Whyte, S.K. Dower, T.J. Williams, and J.E. Pease (2002)
Eur. Respir. J.
19, 350-355
| Abstract »
| Full Text »
| PDF »
- High Cancer Cell Death in Syngeneic Tumors Developed in Host Mice Deficient for the Stromelysin-3 Matrix Metalloproteinase.
- A. Boulay, R. Masson, M.-P. Chenard, M. El Fahime, L. Cassard, J.-P. Bellocq, C. Sautèes-Fridman, P. Basset, and M.-C. Rio (2001)
Cancer Res.
61, 2189-2193
| Abstract »
| Full Text »
- Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways.
- I. Sabroe, A. Hartnell, L. A. Jopling, S. Bel, P. D. Ponath, J. E. Pease, P. D. Collins, and T. J. Williams (1999)
J. Immunol.
162, 2946-2955
| Abstract »
| Full Text »
| PDF »
- Cloning and Characterization of the Guinea Pig Eosinophil Eotaxin Receptor, C-C Chemokine Receptor-3: Blockade Using a Monoclonal Antibody In Vivo.
- I. Sabroe, D. M. Conroy, N. P. Gerard, Y. Li, P. D. Collins, T. W. Post, P. J. Jose, T. J. Williams, C. J. Gerard, and P. D. Ponath (1998)
J. Immunol.
161, 6139-6147
| Abstract »
| Full Text »
| PDF »
- Severity of Airflow Limitation Is Associated with Severity of Airway Inflammation in Smokers.
- A. DI STEFANO, A. CAPELLI, M. LUSUARDI, P. BALBO, C. VECCHIO, P. MAESTRELLI, C. E. MAPP, L. M. FABBRI, C. F. DONNER, and M. SAETTA (1998)
Am. J. Respir. Crit. Care Med.
158, 1277-1285
| Abstract »
| Full Text »
| PDF »
- Searching for Chemokine Receptor Binding Antagonists by High Throughput Screening.
- G. W. Mellor, S. J. Fogarty, M. S. O'Brien, M. Congreve, M. N. Banks, K. M. Mills, B. Jefferies, and J. G. Houston (1997)
J Biomol Screen
2, 153-157
| Abstract »
| PDF »
- A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3. POTENT INHIBITION OF EOSINOPHIL FUNCTION AND CCR3-MEDIATED HIV-1 ENTRY.
- I. Sabroe, M. J. Peck, B. J. Van Keulen, A. Jorritsma, G. Simmons, P. R. Clapham, T. J. Williams, and J. E. Pease (2000)
J. Biol. Chem.
275, 25985-25992
| Abstract »
| Full Text »
| PDF »
|
|
