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Science 17 May 1996:
Vol. 272. no. 5264, pp. 1008 - 1010
DOI: 10.1126/science.272.5264.1008
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Reports

Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1

Richard C. Kurten, Deborah L. Cadena, Gordon N. Gill *

The vectorial movement of proteins requires specific recognition by components of the vesicular trafficking machinery. A protein, sorting nexin-1 (SNX1), was identified in a human cell line that bound to a region of the epidermal growth factor receptor (EGFR) containing the lysosomal targeting code. SNX1 contains a region of homology to a yeast vacuolar sorting protein, and overexpression of SNX1 decreased the amount of EGFR on the cell surface as a result of enhanced rates of constitutive and ligand-induced degradation. Thus, SNX1 is likely to play a role in sorting EGFR to lysosomes.

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0650 USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein.
J. Zhang, X. Zhang, Y. Guo, L. Xu, and D. Pei (2009)
J. Biol. Chem. 284, 21659-21669
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Filamin A Modulates Kinase Activation and Intracellular Trafficking of Epidermal Growth Factor Receptors in Human Melanoma Cells.
J. L. Fiori, T.-N. Zhu, M. P. O'Connell, K. S. Hoek, F. E. Indig, B. P. Frank, C. Morris, S. Kole, J. Hasskamp, G. Elias, et al. (2009)
Endocrinology 150, 2551-2560
   Abstract »    Full Text »    PDF »
Overexpression of Arabidopsis Sorting Nexin AtSNX2b Inhibits Endocytic Trafficking to the Vacuole.
N. Q. Phan, S.-J. Kim, and D. C. Bassham (2008)
Mol Plant 1, 961-976
   Abstract »    Full Text »    PDF »
Lamellar Bodies of Human Epidermis: Proteomics Characterization by High Throughput Mass Spectrometry and Possible Involvement of CLIP-170 in their Trafficking/Secretion.
A.-A. Raymond, A. G. de Peredo, A. Stella, A. Ishida-Yamamoto, D. Bouyssie, G. Serre, B. Monsarrat, and M. Simon (2008)
Mol. Cell. Proteomics 7, 2151-2175
   Abstract »    Full Text »    PDF »
An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.
M. E. Cavet, J. Pang, G. Yin, and B. C. Berk (2008)
FASEB J 22, 3607-3616
   Abstract »    Full Text »    PDF »
The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport.
S. Hara, E. Kiyokawa, S.-i. Iemura, T. Natsume, T. Wassmer, P. J. Cullen, H. Hiai, and M. Matsuda (2008)
Mol. Biol. Cell 19, 3823-3835
   Abstract »    Full Text »    PDF »
Molecular Dissection of Endosomal Compartments in Plants.
J. Muller, U. Mettbach, D. Menzel, and J. Samaj (2007)
Plant Physiology 145, 293-304
   Full Text »    PDF »
The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network.
M. V. Bujny, V. Popoff, L. Johannes, and P. J. Cullen (2007)
J. Cell Sci. 120, 2010-2021
   Abstract »    Full Text »    PDF »
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.
D. M. Bryant, M. C. Kerr, L. A. Hammond, S. R. Joseph, K. E. Mostov, R. D. Teasdale, and J. L. Stow (2007)
J. Cell Sci. 120, 1818-1828
   Abstract »    Full Text »    PDF »
Interchangeable but Essential Functions of SNX1 and SNX2 in the Association of Retromer with Endosomes and the Trafficking of Mannose 6-Phosphate Receptors.
R. Rojas, S. Kametaka, C. R. Haft, and J. S. Bonifacino (2007)
Mol. Cell. Biol. 27, 1112-1124
   Abstract »    Full Text »    PDF »
A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer.
T. Wassmer, N. Attar, M. V. Bujny, J. Oakley, C. J. Traer, and P. J. Cullen (2007)
J. Cell Sci. 120, 45-54
   Abstract »    Full Text »    PDF »
Sorting Nexin 10 Induces Giant Vacuoles in Mammalian Cells.
B. Qin, M. He, X. Chen, and D. Pei (2006)
J. Biol. Chem. 281, 36891-36896
   Abstract »    Full Text »    PDF »
Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis.
L. N. Nguyen, M. S. Holdren, A. P. Nguyen, M. H. Furuya, M. Bianchini, E. Levy, J. Mordoh, A. Liu, G. D. Guncay, J. S. Campbell, et al. (2006)
Clin. Cancer Res. 12, 6952-6959
   Abstract »    Full Text »    PDF »
Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.
B. Zheng, T. Tang, N. Tang, K. Kudlicka, K. Ohtsubo, P. Ma, J. D. Marth, M. G. Farquhar, and E. Lehtonen (2006)
PNAS 103, 16776-16781
   Abstract »    Full Text »    PDF »
Visualisation of macropinosome maturation by the recruitment of sorting nexins.
M. C. Kerr, M. R. Lindsay, R. Luetterforst, N. Hamilton, F. Simpson, R. G. Parton, P. A. Gleeson, and R. D. Teasdale (2006)
J. Cell Sci. 119, 3967-3980
   Abstract »    Full Text »    PDF »
Trafficking of G Protein-Coupled Receptors.
M. T. Drake, S. K. Shenoy, and R. J. Lefkowitz (2006)
Circ. Res. 99, 570-582
   Abstract »    Full Text »    PDF »
An Essential Role for SNX1 in Lysosomal Sorting of Protease-activated Receptor-1: Evidence for Retromer-, Hrs-, and Tsg101-independent Functions of Sorting Nexins.
A. Gullapalli, B. L. Wolfe, C. T. Griffin, T. Magnuson, and J. Trejo (2006)
Mol. Biol. Cell 17, 1228-1238
   Abstract »    Full Text »    PDF »
A Retromerlike Complex Is a Novel Rab7 Effector That Is Involved in the Transport of the Virulence Factor Cysteine Protease in the Enteric Protozoan Parasite Entamoeba histolytica.
K. Nakada-Tsukui, Y. Saito-Nakano, V. Ali, and T. Nozaki (2005)
Mol. Biol. Cell 16, 5294-5303
   Abstract »    Full Text »    PDF »
Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.
C. T. Griffin, J. Trejo, and T. Magnuson (2005)
PNAS 102, 15173-15177
   Abstract »    Full Text »    PDF »
Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
J. G. Carlton, M. V. Bujny, B. J. Peter, V. M. J. Oorschot, A. Rutherford, R. S. Arkell, J. Klumperman, H. T. McMahon, and P. J. Cullen (2005)
J. Cell Sci. 118, 4527-4539
   Abstract »    Full Text »    PDF »
A novel dileucine lysosomal-sorting-signal mediates intracellular EGF-receptor retention independently of protein ubiquitylation.
A. Tsacoumango, S. J. Kil, L. Ma, F. D. Sonnichsen, and C. Carlin (2005)
J. Cell Sci. 118, 3959-3971
   Abstract »    Full Text »    PDF »
Determinants of the Endosomal Localization of Sorting Nexin 1.
Q. Zhong, M. J. Watson, C. S. Lazar, A. M. Hounslow, J. P. Waltho, and G. N. Gill (2005)
Mol. Biol. Cell 16, 2049-2057
   Abstract »    Full Text »    PDF »
A Sorting Nexin PpAtg24 Regulates Vacuolar Membrane Dynamics during Pexophagy via Binding to Phosphatidylinositol-3-Phosphate.
Y. Ano, T. Hattori, M. Oku, H. Mukaiyama, M. Baba, Y. Ohsumi, N. Kato, and Y. Sakai (2005)
Mol. Biol. Cell 16, 446-457
   Abstract »    Full Text »    PDF »
A Library of 7TM Receptor C-terminal Tails: INTERACTIONS WITH THE PROPOSED POST-ENDOCYTIC SORTING PROTEINS ERM-BINDING PHOSPHOPROTEIN 50 (EBP50), N-ETHYLMALEIMIDE-SENSITIVE FACTOR (NSF), SORTING NEXIN 1 (SNX1), AND G PROTEIN-COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN (GASP).
A. Heydorn, B. P. Sondergaard, B. Ersboll, B. Holst, F. C. Nielsen, C. R. Haft, J. Whistler, and T. W. Schwartz (2004)
J. Biol. Chem. 279, 54291-54303
   Abstract »    Full Text »    PDF »
Human Nischarin/Imidazoline Receptor Antisera-selected Protein Is Targeted to the Endosomes by a Combined Action of a PX Domain and a Coiled-coil Region.
K.-P. Lim and W. Hong (2004)
J. Biol. Chem. 279, 54770-54782
   Abstract »    Full Text »    PDF »
Regulation of Epidermal Growth Factor Receptor Degradation by Heterotrimeric G{alpha}s Protein.
B. Zheng, C. Lavoie, T.-D. Tang, P. Ma, T. Meerloo, A. Beas, and M. G. Farquhar (2004)
Mol. Biol. Cell 15, 5538-5550
   Abstract »    Full Text »    PDF »
New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4(a) receptor splice variant: roles in receptor targeting.
L. Joubert, B. Hanson, G. Barthet, M. Sebben, S. Claeysen, W. Hong, P. Marin, A. Dumuis, and J. Bockaert (2004)
J. Cell Sci. 117, 5367-5379
   Abstract »    Full Text »    PDF »
Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain.
J. H. Choi, W.-P. Hong, M. J. Kim, J. H. Kim, S. H. Ryu, and P.-G. Suh (2004)
J. Cell Sci. 117, 4209-4218
   Abstract »    Full Text »    PDF »
Phosphoinositides in Constitutive Membrane Traffic.
M. G. Roth (2004)
Physiol Rev 84, 699-730
   Abstract »    Full Text »    PDF »
Proteomic Analysis of Exosomes Isolated from Human Malignant Pleural Effusions.
M. P. Bard, J. P. Hegmans, A. Hemmes, T. M. Luider, R. Willemsen, L.-A. A. Severijnen, J. P. van Meerbeeck, S. A. Burgers, H. C. Hoogsteden, and B. N. Lambrecht (2004)
Am. J. Respir. Cell Mol. Biol. 31, 114-121
   Abstract »    Full Text »    PDF »
Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe.
T. Koga, M. Onishi, Y. Nakamura, A. Hirata, T. Nakamura, C. Shimoda, T. Iwaki, K. Takegawa, and Y. Fukui (2004)
Genes Cells 9, 561-574
   Abstract »    Full Text »    PDF »
A Role for Sorting Nexin 2 in Epidermal Growth Factor Receptor Down-regulation: Evidence for Distinct Functions of Sorting Nexin 1 and 2 in Protein Trafficking.
A. Gullapalli, T. A. Garrett, M. M. Paing, C. T. Griffin, Y. Yang, and J. Trejo (2004)
Mol. Biol. Cell 15, 2143-2155
   Abstract »    Full Text »    PDF »
Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17.
J. J. Burden, X.-M. Sun, A. B. G. Garcia, and A. K. Soutar (2004)
J. Biol. Chem. 279, 16237-16245
   Abstract »    Full Text »    PDF »
Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
M. N.J. Seaman (2004)
J. Cell Biol. 165, 111-122
   Abstract »    Full Text »    PDF »
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
C. N. Arighi, L. M. Hartnell, R. C. Aguilar, C. R. Haft, and J. S. Bonifacino (2004)
J. Cell Biol. 165, 123-133
   Abstract »    Full Text »    PDF »
Sorting of Ligand-activated Epidermal Growth Factor Receptor to Lysosomes Requires Its Actin-binding Domain.
W. Stoorvogel, S. Kerstens, I. Fritzsche, J. C. d. Hartigh, R. Oud, M. A. G. van der Heyden, J. Voortman, and P. M. P. van Bergen en Henegouwen (2004)
J. Biol. Chem. 279, 11562-11569
   Abstract »    Full Text »    PDF »
Enterophilin-1 Interacts with Focal Adhesion Kinase and Decreases {beta}1 Integrins in Intestinal Caco-2 Cells.
V. Pons, C. Peres, J.-M. Teulie, M. Nauze, M. Mus, C. Rolland, X. Collet, B. Perret, A. Gassama-Diagne, and F. Hullin-Matsuda (2004)
J. Biol. Chem. 279, 9270-9277
   Abstract »    Full Text »    PDF »
Crystal Structure of the Yeast Phox Homology (PX) Domain Protein Grd19p Complexed to Phosphatidylinositol-3-phosphate.
C.-Z. Zhou, I. Li de La Sierra-Gallay, S. Quevillon-Cheruel, B. Collinet, P. Minard, K. Blondeau, G. Henckes, R. Aufrere, N. Leulliot, M. Graille, et al. (2003)
J. Biol. Chem. 278, 50371-50376
   Abstract »    Full Text »    PDF »
A Novel Endocytic Recycling Signal That Distinguishes the Membrane Trafficking of Naturally Occurring Opioid Receptors.
M. Tanowitz and M. von Zastrow (2003)
J. Biol. Chem. 278, 45978-45986
   Abstract »    Full Text »    PDF »
Interaction of Calmodulin, a Sorting Nexin and Kinase-Associated Protein Phosphatase with the Brassica oleracea S Locus Receptor Kinase.
V. Vanoosthuyse, G. Tichtinsky, C. Dumas, T. Gaude, and J. M. Cock (2003)
Plant Physiology 133, 919-929
   Abstract »    Full Text »    PDF »
Evidence for a Role of SNX16 in Regulating Traffic between the Early and Later Endosomal Compartments.
B. J. Hanson and W. Hong (2003)
J. Biol. Chem. 278, 34617-34630
   Abstract »    Full Text »    PDF »
Quantitative Analysis of HER2-mediated Effects on HER2 and Epidermal Growth Factor Receptor Endocytosis: DISTRIBUTION OF HOMO- AND HETERODIMERS DEPENDS ON RELATIVE HER2 LEVELS.
B. S. Hendriks, L. K. Opresko, H. S. Wiley, and D. Lauffenburger (2003)
J. Biol. Chem. 278, 23343-23351
   Abstract »    Full Text »    PDF »
Enterophilin-1, a New Partner of Sorting Nexin 1, Decreases Cell Surface Epidermal Growth Factor Receptor.
V. Pons, F. Hullin-Matsuda, M. Nauze, R. Barbaras, C. Peres, X. Collet, B. Perret, H. Chap, and A. Gassama-Diagne (2003)
J. Biol. Chem. 278, 21155-21161
   Abstract »    Full Text »    PDF »
Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.
C. Leprince, E. Le Scolan, B. Meunier, V. Fraisier, N. Brandon, J. De Gunzburg, and J. Camonis (2003)
J. Cell Sci. 116, 1937-1948
   Abstract »    Full Text »    PDF »
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation.
T. Ago, F. Kuribayashi, H. Hiroaki, R. Takeya, T. Ito, D. Kohda, and H. Sumimoto (2003)
PNAS 100, 4474-4479
   Abstract »    Full Text »    PDF »
Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor.
Y. Lu, Y.-q. Wei, L. Tian, X. Zhao, L. Yang, B. Hu, B. Kan, Y.-j. Wen, F. Liu, H.-x. Deng, et al. (2003)
J. Immunol. 170, 3162-3170
   Abstract »    Full Text »    PDF »
Coregulation of Epidermal Growth Factor Receptor/Human Epidermal Growth Factor Receptor 2 (HER2) Levels and Locations: Quantitative Analysis of HER2 Overexpression Effects.
B. S. Hendriks, L. K. Opresko, H. S. Wiley, and D. Lauffenburger (2003)
Cancer Res. 63, 1130-1137
   Abstract »    Full Text »    PDF »
The Phox Homology (PX) Domain-dependent, 3-Phosphoinositide-mediated Association of Sorting Nexin-1 with an Early Sorting Endosomal Compartment Is Required for Its Ability to Regulate Epidermal Growth Factor Receptor Degradation.
G. E. Cozier, J. Carlton, A. H. McGregor, P. A. Gleeson, R. D. Teasdale, H. Mellor, and P. J. Cullen (2002)
J. Biol. Chem. 277, 48730-48736
   Abstract »    Full Text »    PDF »
Genetic Analysis of Sorting Nexins 1 and 2 Reveals a Redundant and Essential Function in Mice.
D. G. Schwarz, C. T. Griffin, E. A. Schneider, D. Yee, and T. Magnuson (2002)
Mol. Biol. Cell 13, 3588-3600
   Abstract »    Full Text »    PDF »
Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein.
S. Hayashi, T. Okada, N. Igarashi, T. Fujita, S. Jahangeer, and S.-i. Nakamura (2002)
J. Biol. Chem. 277, 33319-33324
   Abstract »    Full Text »    PDF »
Identification of the Functional Domains of Yeast Sorting Nexins Vps5p and Vps17p.
M. N.J. Seaman and H. P. Williams (2002)
Mol. Biol. Cell 13, 2826-2840
   Abstract »    Full Text »    PDF »
Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate and Functions in Endosomal Trafficking.
Y. Li, L.-S. Chin, A. I. Levey, and L. Li (2002)
J. Biol. Chem. 277, 28212-28221
   Abstract »    Full Text »    PDF »
When cell biology meets development: endocytic regulation of signaling pathways.
E. S. Seto, H. J. Bellen, and T. E. Lloyd (2002)
Genes & Dev. 16, 1314-1336
   Full Text »    PDF »
Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1.
Y. Wang, Y. Zhou, K. Szabo, C. R. Haft, and J. Trejo (2002)
Mol. Biol. Cell 13, 1965-1976
   Abstract »    Full Text »    PDF »
Endosomal localization and function of sorting nexin 1.
Q. Zhong, C. S. Lazar, H. Tronchere, T. Sato, T. Meerloo, M. Yeo, Z. Songyang, S. D. Emr, and G. N. Gill (2002)
PNAS 99, 6767-6772
   Abstract »    Full Text »    PDF »
Novel Mechanism for Regulation of Epidermal Growth Factor Receptor Endocytosis Revealed by Protein Kinase A Inhibition.
G. Salazar and A. Gonzalez (2002)
Mol. Biol. Cell 13, 1677-1693
   Abstract »    Full Text »    PDF »
The Cdc42 Target ACK2 Interacts with Sorting Nexin 9 (SH3PX1) to Regulate Epidermal Growth Factor Receptor Degradation.
Q. Lin, C. G. Lo, R. A. Cerione, and W. Yang (2002)
J. Biol. Chem. 277, 10134-10138
   Abstract »    Full Text »    PDF »
Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain".
S. F. Hamm-Alvarez (2002)
Am J Physiol Cell Physiol 282, C417-C419
   Full Text »    PDF »
Location, Location, Location: Membrane Targeting Directed by PX Domains.
T. K. Sato, M. Overduin, and S. D. Emr (2001)
Science 294, 1881-1885
   Abstract »    Full Text »    PDF »
RGS-PX1, a GAP for Galpha s and Sorting Nexin in Vesicular Trafficking.
B. Zheng, Y.-C. Ma, R. S. Ostrom, C. Lavoie, G. N. Gill, P. A. Insel, X.-Y. Huang, and M. G. Farquhar (2001)
Science 294, 1939-1942
   Abstract »    Full Text »    PDF »
The Sorting Nexin, DSH3PX1, Connects the Axonal Guidance Receptor, Dscam, to the Actin Cytoskeleton.
C. A. Worby, N. Simonson-Leff, J. C. Clemens, R. P. Kruger, M. Muda, and J. E. Dixon (2001)
J. Biol. Chem. 276, 41782-41789
   Abstract »    Full Text »    PDF »
Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides.
J. Xu, D. Liu, G. Gill, and Z. Songyang (2001)
J. Cell Biol. 154, 699-706
   Abstract »    Full Text »    PDF »
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
U. Fuchs, G. Rehkamp, O. A. Haas, R. Slany, M. Konig, S. Bojesen, R. M. Bohle, C. Damm-Welk, W.-D. Ludwig, J. Harbott, et al. (2001)
PNAS
   Abstract »    Full Text »    PDF »
Mapping the Binding Domain of Immunoglobulin Light Chains for Tamm-Horsfall Protein.
W.-Z. Ying and P. W. Sanders (2001)
Am. J. Pathol. 158, 1859-1866
   Abstract »    Full Text »    PDF »
The interface of receptor trafficking and signalling.
M. J. Clague and S. Urbe (2001)
J. Cell Sci. 114, 3075-3081
   Abstract »    Full Text »    PDF »
Self-assembly and binding of a sorting nexin to sorting endosomes.
R. Kurten, A. Eddington, P Chowdhury, R. Smith, A. Davidson, and B. Shank (2001)
J. Cell Sci. 114, 1743-1756
   Abstract »    PDF »
Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes.
C. R. Haft, M. d. l. L. Sierra, R. Bafford, M. A. Lesniak, V. A. Barr, and S. I. Taylor (2000)
Mol. Biol. Cell 11, 4105-4116
   Abstract »    Full Text »
E3-13.7 Integral Membrane Proteins Encoded by Human Adenoviruses Alter Epidermal Growth Factor Receptor Trafficking by Interacting Directly with Receptors in Early Endosomes.
D. Crooks, S. J. Kil, J. M. McCaffery, and C. Carlin (2000)
Mol. Biol. Cell 11, 3559-3572
   Abstract »    Full Text »
Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.
Y. Takemoto, M. Furuta, M. Sato, M. Kubo, and Y. Hashimoto (1999)
Int. Immunol. 11, 1957-1964
   Abstract »    Full Text »    PDF »
Interaction of the Metalloprotease Disintegrins MDC9 and MDC15 with Two SH3 Domain-containing Proteins, Endophilin I and SH3PX1.
L. Howard, K. K. Nelson, R. A. Maciewicz, and C. P. Blobel (1999)
J. Biol. Chem. 274, 31693-31699
   Abstract »    Full Text »    PDF »
ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors.
R. Worthylake, L. K. Opresko, and H. S. Wiley (1999)
J. Biol. Chem. 274, 8865-8874
   Abstract »    Full Text »    PDF »
Metabolic Stabilization of Muscle Nicotinic Acetylcholine Receptor by Rapsyn.
Z.-Z. Wang, A. Mathias, M. Gautam, and Z. W. Hall (1999)
J. Neurosci. 19, 1998-2007
   Abstract »    Full Text »    PDF »
A Leucine-based Determinant in the Epidermal Growth Factor Receptor Juxtamembrane Domain Is Required for the Efficient Transport of Ligand-Receptor Complexes to Lysosomes.
S. J. Kil, M. Hobert, and C. Carlin (1999)
J. Biol. Chem. 274, 3141-3150
   Abstract »    Full Text »    PDF »
A Discrete Three-amino Acid Segment (LVI) at the C-terminal End of Kinase-impaired ErbB3 Is Required for Transactivation of ErbB2.
G. Schaefer, R. W. Akita, and M. X. Sliwkowski (1999)
J. Biol. Chem. 274, 859-866
   Abstract »    Full Text »    PDF »
Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation.
R. Moore, A Tuffaha, E. Millman, W Dai, H. Hall, B. Dickey, and B. Knoll (1999)
J. Cell Sci. 112, 329-338
   Abstract »    PDF »
Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors.
C. R. Haft, M. de la Luz Sierra, V. A. Barr, D. H. Haft, and S. I. Taylor (1998)
Mol. Cell. Biol. 18, 7278-7287
   Abstract »    Full Text »    PDF »
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.
G. Levkowitz, H. Waterman, E. Zamir, Z. Kam, S. Oved, W. Y. Langdon, L. Beguinot, B. Geiger, and Y. Yarden (1998)
Genes & Dev. 12, 3663-3674
   Abstract »    Full Text »
Molecular Characterization of the Signal Responsible for the Targeting of the Interleukin 2 Receptor beta  Chain toward Intracellular Degradation.
A. Subtil, A. Rocca, and A. Dautry-Varsat (1998)
J. Biol. Chem. 273, 29424-29429
   Abstract »    Full Text »    PDF »
Vam7p, a SNAP-25-Like Molecule, and Vam3p, a Syntaxin Homolog, Function Together in Yeast Vacuolar Protein Trafficking.
T. K. Sato, T. Darsow, and S. D. Emr (1998)
Mol. Cell. Biol. 18, 5308-5319
   Abstract »    Full Text »    PDF »
A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast.
M. N.J. Seaman, J. Michael McCaffery, and S. D. Emr (1998)
J. Cell Biol. 142, 665-681
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of Selected Secretory Carrier Membrane Proteins, SCAMP1 and SCAMP3, and Association with the EGF Receptor.
T. T. Wu and J. D. Castle (1998)
Mol. Biol. Cell 9, 1661-1674
   Abstract »    Full Text »
Role of Tyrosine Phosphorylation in Ligand-induced Regulation of Transcytosis of the Polymeric Ig Receptor.
F. Luton, M. H. Cardone, M. Zhang, and K. E. Mostov (1998)
Mol. Biol. Cell 9, 1787-1802
   Abstract »    Full Text »
Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the beta 2-Adrenergic Receptor.
A. W. Gagnon, L. Kallal, and J. L. Benovic (1998)
J. Biol. Chem. 273, 6976-6981
   Abstract »    Full Text »    PDF »
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M. E. Hobert, S. J. Kil, M. E. Medof, and C. R. Carlin (1997)
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Structural Aspects of the Epidermal Growth Factor Receptor Required for Transmodulation of erbB-2/neu.
R. Worthylake and H. S. Wiley (1997)
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The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling.
H.-J. S. Huang, M. Nagane, C. K. Klingbeil, H. Lin, R. Nishikawa, X.-D. Ji, C.-M. Huang, G. N. Gill, H. S. Wiley, and W. K. Cavenee (1997)
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The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.
S. Nothwehr and A. Hindes (1997)
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Overexpression of the Epidermal Growth Factor Receptor Contributes to Enhanced Ligand-Mediated Motility in Keratinocyte Cell Lines.
L. J. McCawley, P. O'Brien, and L. G. Hudson (1997)
Endocrinology 138, 121-127
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Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis.
A. V. Vieira, C. Lamaze, and S. L. Schmid (1996)
Science 274, 2086-2089
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Lysosomal Targeting of Epidermal Growth Factor Receptors via a Kinase-dependent Pathway Is Mediated by the Receptor Carboxyl-terminal Residues 1022-1123.
E. Kornilova, T. Sorkina, L. Beguinot, and A. Sorkin (1996)
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Intracellular Retention and Degradation of the Epidermal Growth Factor Receptor, Two Distinct Processes Mediated by Benzoquinone Ansamycins.
L. Supino-Rosin, A. Yoshimura, Y. Yarden, Z. Elazar, and D. Neumann (2000)
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Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor.
L.-S. Chin, M. C. Raynor, X. Wei, H.-Q. Chen, and L. Li (2001)
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Identification and Characterization of SNX15, a Novel Sorting Nexin Involved in Protein Trafficking.
S. A. Phillips, V. A. Barr, D. H. Haft, S. I. Taylor, and C. R. Haft (2001)
J. Biol. Chem. 276, 5074-5084
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Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-beta Family of Receptor Serine-Threonine Kinases.
W. T. Parks, D. B. Frank, C. Huff, C. Renfrew Haft, J. Martin, X. Meng, M. P. de Caestecker, J. G. McNally, A. Reddi, S. I. Taylor, et al. (2001)
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Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.
J. C. Clemens, C. A. Worby, N. Simonson-Leff, M. Muda, T. Maehama, B. A. Hemmings, and J. E. Dixon (2000)
PNAS 97, 6499-6503
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The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
U. Fuchs, G. Rehkamp, O. A. Haas, R. Slany, M. Konig, S. Bojesen, R. M. Bohle, C. Damm-Welk, W.-D. Ludwig, J. Harbott, et al. (2001)
PNAS 98, 8756-8761
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Human VPS34 is required for internal vesicle formation within multivesicular endosomes.
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