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Science 3 May 1996:
Vol. 272. no. 5262, pp. 625 - 0
DOI:

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This Week in Science

twis image During development of the digits in vertebrates, programmed cell death (apoptosis) causes the loss of interdigital tissue in order to define the digits. Zou and Niswander (p. 738) examined the role of the bone morphogenetic protein (BMP) in interdigital apoptosis. The blockage of BMP signal transduction in the developing chick limb by the expression of a dominant negative BMP receptor reduced apoptosis, which resulted in webbed feet as well as a transformation of scales to feathers.




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