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Science 19 April 1996:
Vol. 272. no. 5260, pp. 371 - 0
DOI: 10.1126/science.272.5260.371
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Perspectives

Alan P. Wolffe

Histones are DNA binding proteins that bind without regard to the sequence of the DNA and help determine the three-dimensional organization of the chromatin into chromosomes. A paper in this week's issue (Taunton et al., p. 408) reports the cloning of histone deacetylase, an ezyme that modifies histones by removing an acetyl group. In his Perspective, Wolffe explains how the action of this enzyme can lead to the regulation of the transcription of certain genes.

The author is at the Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 6, Room B1A13, 9000 Rockville Pike, Bethesda, MD 20892-2710, USA. E-mail: awlme@helix.nih.gov


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Genetics 150, 987-1005
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Different Classes of Coactivators Recognize Distinct but Overlapping Binding Sites on the Estrogen Receptor Ligand Binding Domain.
F. C. S. Eng, A. Barsalou, N. Akutsu, I. Mercier, C. Zechel, S. Mader, and J. H. White (1998)
J. Biol. Chem. 273, 28371-28377
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NDT80 and the Meiotic Recombination Checkpoint Regulate Expression of Middle Sporulation-Specific Genes in Saccharomyces cerevisiae.
S. R. Hepworth, H. Friesen, and J. Segall (1998)
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Histone Deacetylase Homologs Regulate Epigenetic Inheritance of Transcriptional Silencing and Chromosome Segregation in Fission Yeast.
S. I. S. Grewal, M. J. Bonaduce, and A. J. S. Klar (1998)
Genetics 150, 563-576
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Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators.
M. J. Pikaart, F. Recillas-Targa, and G. Felsenfeld (1998)
Genes & Dev. 12, 2852-2862
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The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase.
R. Ferreira, L. Magnaghi-Jaulin, P. Robin, A. Harel-Bellan, and D. Trouche (1998)
PNAS 95, 10493-10498
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Purification and Characterization of a Protein Binding to the SP6 kappa  Promoter. A POTENTIAL ROLE FOR CArG-BOX BINDING FACTOR-A IN kappa  TRANSCRIPTION.
M. Bemark, H. Olsson, D. Heinegard, and T. Leanderson (1998)
J. Biol. Chem. 273, 18881-18890
   Abstract »    Full Text »    PDF »
Characterization of BCE-1, a Transcriptional Enhancer Regulated by Prolactin and Extracellular Matrix and Modulated by the State of Histone Acetylation.
C. A. Myers, C. Schmidhauser, J. Mellentin-Michelotti, G. Fragoso, C. D. Roskelley, G. Casperson, R. Mossi, P. Pujuguet, G. Hager, and M. J. Bissell (1998)
Mol. Cell. Biol. 18, 2184-2195
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A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans.
Y. Shi and C. Mello (1998)
Genes & Dev. 12, 943-955
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Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase.
H. J. Kwon, T. Owa, C. A. Hassig, J. Shimada, and S. L. Schreiber (1998)
PNAS 95, 3356-3361
   Abstract »    Full Text »    PDF »
Histone Deacetylase Directs the Dominant Silencing of Transcription in Chromatin: Association with MeCP2 and the Mi-2 Chromodomain SWI/SNF ATPase.
P.A. WADE, P.L. JONES, D. VERMAAK, G.J.C. VEENSTRA, A. IMHOF, T. SERA, C. TSE, H. GE, Y.-B. SHI, J.C. HANSEN, et al. (1998)
Cold Spring Harb Symp Quant Biol 63, 435-446
   Abstract »    PDF »
Localization and activity of lysyl oxidase within nuclei of fibrogenic cells.
W. Li, K. Nellaiappan, T. Strassmaier, L. Graham, K. M. Thomas, and H. M. Kagan (1997)
PNAS 94, 12817-12822
   Abstract »    Full Text »    PDF »
Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family.
W.-M. Yang, Y.-L. Yao, J.-M. Sun, J. R. Davie, and E. Seto (1997)
J. Biol. Chem. 272, 28001-28007
   Abstract »    Full Text »    PDF »
Steroid receptor induction of gene transcription: A two-step model.
G. Jenster, T. E. Spencer, M. M. Burcin, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley (1997)
PNAS 94, 7879-7884
   Abstract »    Full Text »    PDF »
Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.
W. Y. Chen, E. C. Bailey, S. L. McCune, J.-Y. Dong, and T. M. Townes (1997)
PNAS 94, 5798-5803
   Abstract »    Full Text »    PDF »
c-Myb trans-Activates the Human DNA Topoisomerase IIalpha Gene Promoter.
T. L. Brandt, D. J. Fraser, S. Leal, P. M. Halandras, A. R. Kroll, and D. J. Kroll (1997)
J. Biol. Chem. 272, 6278-6284
   Abstract »    Full Text »    PDF »
p300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation.
M. Fu, C. Wang, A. T. Reutens, J. Wang, R. H. Angeletti, L. Siconolfi-Baez, V. Ogryzko, M.-L. Avantaggiati, and R. G. Pestell (2000)
J. Biol. Chem. 275, 20853-20860
   Abstract »    Full Text »    PDF »
Inhibition of Mitogenesis in Balb/c-3T3 Cells by Trichostatin A. MULTIPLE ALTERATIONS IN THE INDUCTION AND ACTIVATION OF CYCLIN-CYCLIN-DEPENDENT KINASE COMPLEXES.
W. Wharton, J. Savell, W. D. Cress, E. Seto, and W. J. Pledger (2000)
J. Biol. Chem. 275, 33981-33987
   Abstract »    Full Text »    PDF »
Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells.
S. H. Kwon, S. H. Ahn, Y. K. Kim, G.-U. Bae, J. W. Yoon, S. Hong, H. Y. Lee, Y.-W. Lee, H.-W. Lee, and J.-W. Han (2002)
J. Biol. Chem. 277, 2073-2080
   Abstract »    Full Text »    PDF »
Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor.
E. Hu, Z. Chen, T. Fredrickson, Y. Zhu, R. Kirkpatrick, G.-F. Zhang, K. Johanson, C.-M. Sung, R. Liu, and J. Winkler (2000)
J. Biol. Chem. 275, 15254-15264
   Abstract »    Full Text »    PDF »


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