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Science 12 April 1996:
Vol. 272. no. 5259, pp. 263 - 267
DOI: 10.1126/science.272.5259.263
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Reports

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Luigi Naldini, Ulrike Blömer, Philippe Gallay, Daniel Ory, Richard Mulligan, Fred H. Gage, Inder M. Verma, * Didier Trono

A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.

L. Naldini, U. Blömer, P. Gallay, F. H. Gage, I. M. Verma, D. Trono, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
D. Ory and R. Mulligan, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
* To whom correspondence should be addressed.


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A Novel RET Kinase-{beta}-Catenin Signaling Pathway Contributes to Tumorigenesis in Thyroid Carcinoma.
T. S. Gujral, W. van Veelen, D. S. Richardson, S. M. Myers, J. A. Meens, D. S. Acton, M. Dunach, B. E. Elliott, J. W.M. Hoppener, and L. M. Mulligan (2008)
Cancer Res. 68, 1338-1346
   Abstract »    Full Text »    PDF »
Antiretroviral Activity of Ancestral TRIM5{alpha}.
V. Goldschmidt, A. Ciuffi, M. Ortiz, D. Brawand, M. Munoz, H. Kaessmann, and A. Telenti (2008)
J. Virol. 82, 2089-2096
   Abstract »    Full Text »    PDF »
Pseudodiploid Genome Organization Aids Full-Length Human Immunodeficiency Virus Type 1 DNA Synthesis.
S. R. King, N. K. Duggal, C. B. Ndongmo, C. Pacut, and A. Telesnitsky (2008)
J. Virol. 82, 2376-2384
   Abstract »    Full Text »    PDF »
Fusogenicity of Jaagsiekte Sheep Retrovirus Envelope Protein Is Dependent on Low pH and Is Enhanced by Cytoplasmic Tail Truncations.
M. Cote, Y.-M. Zheng, L. M. Albritton, and S.-L. Liu (2008)
J. Virol. 82, 2543-2554
   Abstract »    Full Text »    PDF »
Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells.
I. Seiden-Long, R. Navab, W. Shih, M. Li, J. Chow, C. Q. Zhu, N. Radulovich, C. Saucier, and M.-S. Tsao (2008)
Carcinogenesis 29, 647-655
   Abstract »    Full Text »    PDF »
Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.
F. E. O'Keeffe, S. A. Scott, P. Tyers, G. W. O'Keeffe, J. W. Dalley, R. Zufferey, and M. A. Caldwell (2008)
Brain 131, 630-641
   Abstract »    Full Text »    PDF »
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
K. Mizuta, G. Gallos, D. Zhu, F. Mizuta, F. Goubaeva, D. Xu, R. A. Panettieri Jr., J. Yang, and C. W. Emala Sr. (2008)
Am J Physiol Lung Cell Mol Physiol 294, L523-L534
   Abstract »    Full Text »    PDF »
Neuroprotection by Neurotrophic Factors and Membrane Depolarization Is Regulated by Calmodulin Kinase IV.
M. J. Perez-Garcia, M. Gou-Fabregas, Y. de Pablo, M. Llovera, J. X. Comella, and R. M. Soler (2008)
J. Biol. Chem. 283, 4133-4144
   Abstract »    Full Text »    PDF »
SOX-18 controls endothelial-specific claudin-5 gene expression and barrier function.
R. D. Fontijn, O. L. Volger, J. O. Fledderus, A. Reijerkerk, H. E. de Vries, and A. J. G. Horrevoets (2008)
Am J Physiol Heart Circ Physiol 294, H891-H900
   Abstract »    Full Text »    PDF »
Gene Therapy Applications for Fracture-Healing.
B. C. Carofino and J. R. Lieberman (2008)
J. Bone Joint Surg. Am. 90, 99-110
   Abstract »    Full Text »    PDF »
Herpes Simplex Virus Type 1 Preferentially Targets Human Colon Carcinoma: Role of Extracellular Matrix.
D. Kolodkin-Gal, G. Zamir, Y. Edden, E. Pikarsky, A. Pikarsky, H. Haim, Y. S. Haviv, and A. Panet (2008)
J. Virol. 82, 999-1010
   Abstract »    Full Text »    PDF »
Inhibition of RAS-Mediated Transformation and Tumorigenesis by Targeting the Downstream E3 Ubiquitin Ligase Seven in Absentia Homologue.
R. L. Schmidt, C. H. Park, A. U. Ahmed, J. H. Gundelach, N. R. Reed, S. Cheng, B. E. Knudsen, and A. H. Tang (2007)
Cancer Res. 67, 11798-11810
   Abstract »    Full Text »    PDF »
DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication.
Y. Ariumi, M. Kuroki, K.-i. Abe, H. Dansako, M. Ikeda, T. Wakita, and N. Kato (2007)
J. Virol. 81, 13922-13926
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Normal Brain Cells Contribute to the Bystander Effect in Suicide Gene Therapy of Malignant Glioma.
H. Miletic, Y. H. Fischer, T. Giroglou, M. A. Rueger, A. Winkeler, H. Li, U. Himmelreich, W. Stenzel, A. H. Jacobs, and D. von Laer (2007)
Clin. Cancer Res. 13, 6761-6768
   Abstract »    Full Text »    PDF »
Inhibitory role of CXCR4 glycan in CD4-independent X4-tropic human immunodeficiency virus type 1 infection and its abrogation in CD4-dependent infection.
Y. Kubo, M. Yokoyama, H. Yoshii, C. Mitani, C. Tominaga, Y. Tanaka, H. Sato, and N. Yamamoto (2007)
J. Gen. Virol. 88, 3139-3144
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Identification of an Arsenic-Sensitive Block to Primate Lentiviral Infection of Human Dendritic Cells.
M. Pion, R. Stalder, R. Correa, B. Mangeat, G. J. Towers, and V. Piguet (2007)
J. Virol. 81, 12086-12090
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Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity.
R. B. Sekar, E. Kizana, R. R. Smith, A. S. Barth, Y. Zhang, E. Marban, and L. Tung (2007)
Am J Physiol Heart Circ Physiol 293, H2757-H2770
   Abstract »    Full Text »    PDF »
Lentiviral vectors: are they the future of animal transgenesis?.
F. Park (2007)
Physiol Genomics 31, 159-173
   Abstract »    Full Text »    PDF »


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