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Science 5 April 1996:
Vol. 272. no. 5258, p. 47
DOI: 10.1126/science.272.5258.47
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Perspectives

Mary Shannon Moore

Certain cytoplasmic proteins are actively transported into the nucleus through nuclear pores. In a paper in this week's issue the function of a participating soluble protein, p10, is elucidated (Nehrbass and Blobel, p. 120). Moore explains, in her Perspective, how these findings solve the riddle of the source of one of the molecules required for transport, GTP-Ran.

The author is in the Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. E-mail: mmoore@bcm.tmc.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lpsd/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses.
P. M. C. Wong, A. Kang, H. Chen, Q. Yuan, P. Fan, B. M. Sultzer, Y. W. Kan, and S.-W. Chung (1999)
PNAS 96, 11543-11548
   Abstract »    Full Text »    PDF »
Ran, a GTPase involved in nuclear processes: its regulators and effectors.
J. Avis and P. Clarke (1996)
J. Cell Sci. 109, 2423-2427
   Abstract »    PDF »
A Single Point Mutation at the 3'-Untranslated Region of Ran mRNA Leads to Profound Changes in Lipopolysaccharide Endotoxin-mediated Responses.
P. M. C. Wong, Q. Yuan, H. Chen, B. M. Sultzer, and S.-W. Chung (2001)
J. Biol. Chem. 276, 33129-33138
   Abstract »    Full Text »    PDF »


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