Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 March 1996:
Vol. 271. no. 5257, pp. 1873 - 1876
DOI: 10.1126/science.271.5257.1873
Prev | Table of Contents | Next

Reports

An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene

Ali Shilatifard, William S. Lane, Kenneth W. Jackson, Ronald C. Conaway, Joan W. Conaway *

The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax-like MLL gene on chromosome 11 in acute myeloid leukemias. Here, ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene. The discovery of a second elongation factor implicated in oncogenesis provides further support for a close connection between the regulation of transcription elongation and cell growth.

A. Shilatifard, R. C. Conaway, J. W. Conaway, Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
W. S. Lane, Harvard Microchemistry Facility, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
K. W. Jackson, William K. Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA.
* To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
J. S. Byun, M. M. Wong, W. Cui, G. Idelman, Q. Li, A. De Siervi, S. Bilke, C. M. Haggerty, A. Player, Y. H. Wang, et al. (2009)
PNAS 106, 19286-19291
   Abstract »    Full Text »    PDF »
Direct Inhibition of RNA Polymerase II Transcription by RECQL5.
O. Aygun, X. Xu, Y. Liu, H. Takahashi, S. E. Kong, R. C. Conaway, J. W. Conaway, and J. Q. Svejstrup (2009)
J. Biol. Chem. 284, 23197-23203
   Abstract »    Full Text »    PDF »
Elongation Factor ELL (Eleven-Nineteen Lysine-rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation.
J. Zhou, X. Feng, B. Ban, J. Liu, Z. Wang, and W. Xiao (2009)
J. Biol. Chem. 284, 19142-19152
   Abstract »    Full Text »    PDF »
The molecular biology of mixed lineage leukemia.
R. K. Slany (2009)
Haematologica 94, 984-993
   Abstract »    Full Text »    PDF »
Zebrafish eaf1 and eaf2/u19 Mediate Effective Convergence and Extension Movements through the Maintenance of wnt11 and wnt5 Expression.
J.-X. Liu, B. Hu, Y. Wang, J.-F. Gui, and W. Xiao (2009)
J. Biol. Chem. 284, 16679-16692
   Abstract »    Full Text »    PDF »
Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation.
M. Nagata, T. Ito, N. Arimitsu, H. Koyama, and K. Sekimizu (2009)
Genes Cells 14, 371-380
   Abstract »    Full Text »    PDF »
Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL.
C. A. S. Banks, S. E. Kong, H. Spahr, L. Florens, S. Martin-Brown, M. P. Washburn, J. W. Conaway, A. Mushegian, and R. C. Conaway (2007)
J. Biol. Chem. 282, 5761-5769
   Abstract »    Full Text »    PDF »
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
E. Bitoun, P. L. Oliver, and K. E. Davies (2007)
Hum. Mol. Genet. 16, 92-106
   Abstract »    Full Text »    PDF »
Transcription Elongation Factor S-II Is Required for Definitive Hematopoiesis.
T. Ito, N. Arimitsu, M. Takeuchi, N. Kawamura, M. Nagata, K. Saso, N. Akimitsu, H. Hamamoto, S. Natori, A. Miyajima, et al. (2006)
Mol. Cell. Biol. 26, 3194-3203
   Abstract »    Full Text »    PDF »
Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII.
K. Bowers, S. C. Piper, M. A. Edeling, S. R. Gray, D. J. Owen, P. J. Lehner, and J. P. Luzio (2006)
J. Biol. Chem. 281, 5094-5105
   Abstract »    Full Text »    PDF »
Mutational Analysis of an RNA Polymerase II Elongation Factor in Drosophila melanogaster.
M. A. Gerber, A. Shilatifard, and J. C. Eissenberg (2005)
Mol. Cell. Biol. 25, 7803-7811
   Abstract »    Full Text »    PDF »
The Mineralocorticoid Receptor: A Journey Exploring Its Diversity and Specificity of Action.
L. Pascual-Le Tallec and M. Lombes (2005)
Mol. Endocrinol. 19, 2211-2221
   Abstract »    Full Text »    PDF »
ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.
S. E. Kong, C. A. S. Banks, A. Shilatifard, J. W. Conaway, and R. C. Conaway (2005)
PNAS 102, 10094-10098
   Abstract »    Full Text »    PDF »
In Vivo Requirement of the RNA Polymerase II Elongation Factor Elongin A for Proper Gene Expression and Development.
M. Gerber, J. C. Eissenberg, S. Kong, K. Tenney, J. W. Conaway, R. C. Conaway, and A. Shilatifard (2004)
Mol. Cell. Biol. 24, 9911-9919
   Abstract »    Full Text »    PDF »
Elongation by RNA polymerase II: the short and long of it.
R. J. Sims III, R. Belotserkovskaya, and D. Reinberg (2004)
Genes & Dev. 18, 2437-2468
   Abstract »    Full Text »    PDF »
Large-Scale Identification of Disease Genes Involved in Acute Myeloid Leukemia.
S. J. Erkeland, M. Valkhof, C. Heijmans-Antonissen, A. van Hoven-Beijen, R. Delwel, M. H. A. Hermans, and I. P. Touw (2004)
J. Virol. 78, 1971-1980
   Abstract »    Full Text »    PDF »
Molecular Evidence That the Eukaryotic THO/TREX Complex Is Required for Efficient Transcription Elongation.
A. G. Rondon, S. Jimeno, M. Garcia-Rubio, and A. Aguilera (2003)
J. Biol. Chem. 278, 39037-39043
   Abstract »    Full Text »    PDF »
Transcriptional Elongation by RNA Polymerase II and Histone Methylation.
M. Gerber and A. Shilatifard (2003)
J. Biol. Chem. 278, 26303-26306
   Abstract »    Full Text »    PDF »
Molecular Basis of p53 Functional Inactivation by the Leukemic Protein MLL-ELL.
D. Wiederschain, H. Kawai, J. Gu, A. Shilatifard, and Z.-M. Yuan (2003)
Mol. Cell. Biol. 23, 4230-4246
   Abstract »    Full Text »    PDF »
Identification of a Novel Tissue-Specific Transcriptional Activator FESTA as a Protein That Interacts with the Transcription Elongation Factor S-II.
K. Saso, T. Ito, S. Natori, and K. Sekimizu (2003)
J. Biochem. 133, 493-500
   Abstract »    Full Text »    PDF »
ELL and EAF1 are Cajal Body Components That Are Disrupted in MLL-ELL Leukemia.
P. E. Polak, F. Simone, J. J. Kaberlein, R. T. Luo, and M. J. Thirman (2003)
Mol. Biol. Cell 14, 1517-1528
   Abstract »    Full Text »    PDF »
ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties.
F. Simone, R. T. Luo, P. E. Polak, J. J. Kaberlein, and M. J. Thirman (2003)
Blood 101, 2355-2362
   Abstract »    Full Text »    PDF »
dELL is an essential RNA polymerase II elongation factor with a general role in development.
J. C. Eissenberg, J. Ma, M. A. Gerber, A. Christensen, J. A. Kennison, and A. Shilatifard (2002)
PNAS 99, 9894-9899
   Abstract »    Full Text »    PDF »
LCX, Leukemia-associated Protein with a CXXC Domain, Is Fused to MLL in Acute Myeloid Leukemia with Trilineage Dysplasia Having t(10;11)(q22;q23).
R. Ono, T. Taki, T. Taketani, M. Taniwaki, H. Kobayashi, and Y. Hayashi (2002)
Cancer Res. 62, 4075-4080
   Abstract »    Full Text »    PDF »
Identification and Biochemical Characterization of a Novel Transcription Elongation Factor, Elongin A3.
K. Yamazaki, L. Guo, K. Sugahara, C. Zhang, H. Enzan, Y. Nakabeppu, S. Kitajima, and T. Aso (2002)
J. Biol. Chem. 277, 26444-26451
   Abstract »    Full Text »    PDF »
Regulation of Stress Response Signaling by the N-terminal Dishevelled/EGL-10/Pleckstrin Domain of Sst2, a Regulator of G Protein Signaling in Saccharomyces cerevisiae.
S. A. Burchett, P. Flanary, C. Aston, L. Jiang, K. H. Young, P. Uetz, S. Fields, and H. G. Dohlman (2002)
J. Biol. Chem. 277, 22156-22167
   Abstract »    Full Text »    PDF »
Characterization of a Six-Subunit Holo-Elongator Complex Required for the Regulated Expression of a Group of Genes in Saccharomyces cerevisiae.
N. J. Krogan and J. F. Greenblatt (2001)
Mol. Cell. Biol. 21, 8203-8212
   Abstract »    Full Text »    PDF »
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein.
T. Miller, N. J. Krogan, J. Dover, H. Erdjument-Bromage, P. Tempst, M. Johnston, J. F. Greenblatt, and A. Shilatifard (2001)
PNAS
   Abstract »    Full Text »    PDF »
Hpr1 Is Preferentially Required for Transcription of Either Long or G+C-Rich DNA Sequences in Saccharomyces cerevisiae.
S. Chavez, M. Garcia-Rubio, F. Prado, and A. Aguilera (2001)
Mol. Cell. Biol. 21, 7054-7064
   Abstract »    Full Text »    PDF »
The Elongation Domain of ELL Is Dispensable but Its ELL-Associated Factor 1 Interaction Domain Is Essential for MLL-ELL-Induced Leukemogenesis.
R. T. Luo, C. Lavau, C. Du, F. Simone, P. E. Polak, S. Kawamata, and M. J. Thirman (2001)
Mol. Cell. Biol. 21, 5678-5687
   Abstract »    Full Text »    PDF »
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.
F. Simone, P. E. Polak, J. J. Kaberlein, R. T. Luo, D. A. Levitan, and M. J. Thirman (2001)
Blood 98, 201-209
   Abstract »    Full Text »    PDF »
Functional Analysis of the Leukemia Protein ELL: Evidence for a Role in the Regulation of Cell Growth and Survival.
R. W. Johnstone, M. Gerber, T. Landewe, A. Tollefson, W. S. Wold, and A. Shilatifard (2001)
Mol. Cell. Biol. 21, 1672-1681
   Abstract »    Full Text »
A New Hyperrecombination Mutation Identifies a Novel Yeast Gene, THP1, Connecting Transcription Elongation With Mitotic Recombination.
M. Gallardo and A. Aguilera (2001)
Genetics 157, 79-89
   Abstract »    Full Text »
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
J. F. DiMartino, T. Miller, P. M. Ayton, T. Landewe, J. L. Hess, M. L. Cleary, and A. Shilatifard (2000)
Blood 96, 3887-3893
   Abstract »    Full Text »    PDF »
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.
C. Lavau, R. T. Luo, C. Du, and M. J. Thirman (2000)
PNAS
   Abstract »    Full Text »
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.
S. Vispé, T. M. C. Yung, J. Ritchot, H. Serizawa, and M. S. Satoh (2000)
PNAS
   Abstract »    Full Text »
Panhandle PCR for cDNA: A rapid method for isolation of MLL fusion transcripts involving unknown partner genes.
M. D. Megonigal, E. F. Rappaport, R. B. Wilson, D. H. Jones, J. A. Whitlock, J. A. Ortega, D. J. Slater, P. C. Nowell, and C. A. Felix (2000)
PNAS
   Abstract »    Full Text »
Elongin from Saccharomyces cerevisiae.
C. M. Koth, M. V. Botuyan, R. J. Moreland, D. B. Jansma, J. W. Conaway, R. C. Conaway, W. J. Chazin, J. D. Friesen, C. H. Arrowsmith, and A. M. Edwards (2000)
J. Biol. Chem. 275, 11174-11180
   Abstract »    Full Text »    PDF »
SN-1, A Novel Leukemic Cell Line with t(11;16)(q23;p13): Myeloid Characteristics and Resistance to Retinoids and Vitamin D3.
Y. Hayashi, Y. Honma, N. Niitsu, T. Taki, F. Bessho, M. Sako, T. Mori, M. Yanagisawa, K. Tsuji, and T. Nakahata (2000)
Cancer Res. 60, 1139-1145
   Abstract »    Full Text »
Vaccinia Virus Gene A18R DNA Helicase Is a Transcript Release Factor.
C. A. Lackner and R. C. Condit (2000)
J. Biol. Chem. 275, 1485-1494
   Abstract »    Full Text »    PDF »
Dual Roles for Transcription Factor IIF in Promoter Escape by RNA Polymerase II.
Q. Yan, R. J. Moreland, J. W. Conaway, and R. C. Conaway (1999)
J. Biol. Chem. 274, 35668-35675
   Abstract »    Full Text »    PDF »
AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23).
T. Taki, H. Kano, M. Taniwaki, M. Sako, M. Yanagisawa, and Y. Hayashi (1999)
PNAS 96, 14535-14540
   Abstract »    Full Text »    PDF »
Leukemic HRX Fusion Proteins Inhibit GADD34-Induced Apoptosis and Associate with the GADD34 and hSNF5/INI1 Proteins.
H. T. Adler, R. Chinery, D. Y. Wu, S. J. Kussick, J. M. Payne, A. J. Fornace Jr., and D. C. Tkachuk (1999)
Mol. Cell. Biol. 19, 7050-7060
   Abstract »    Full Text »    PDF »
AF17q25, a Putative Septin Family Gene, Fuses the MLL Gene in Acute Myeloid Leukemia with t(11;17)(q23;q25).
T. Taki, H. Ohnishi, K. Shinohara, M. Sako, F. Bessho, M. Yanagisawa, and Y. Hayashi (1999)
Cancer Res. 59, 4261-4265
   Abstract »    Full Text »    PDF »
Cloning and Characterization of the EAP30 Subunit of the ELL Complex That Confers Derepression of Transcription by RNA Polymerase II.
A. E. Schmidt, T. Miller, S. L. Schmidt, R. Shiekhattar, and A. Shilatifard (1999)
J. Biol. Chem. 274, 21981-21985
   Abstract »    Full Text »    PDF »
Physical Interaction and Functional Antagonism between the RNA Polymerase II Elongation Factor ELL and p53.
N. Shinobu, T. Maeda, T. Aso, T. Ito, T. Kondo, K. Koike, and M. Hatakeyama (1999)
J. Biol. Chem. 274, 17003-17010
   Abstract »    Full Text »    PDF »
DNA Bending and Wrapping around RNA Polymerase: a ""Revolutionary"" Model Describing Transcriptional Mechanisms.
B. Coulombe and Z. F. Burton (1999)
Microbiol. Mol. Biol. Rev. 63, 457-478
   Abstract »    Full Text »    PDF »
Transcriptional Inhibition of p53 by the MLL/MEN Chimeric Protein Found in Myeloid Leukemia.
K. Maki, K. Mitani, T. Yamagata, M. Kurokawa, Y. Kanda, Y. Yazaki, and H. Hirai (1999)
Blood 93, 3216-3224
   Abstract »    Full Text »    PDF »
AF4 Encodes a Ubiquitous Protein That in Both Native and MLL-AF4 Fusion Types Localizes to Subnuclear Compartments.
Q. Li, J. L. Frestedt, and J. H. Kersey (1998)
Blood 92, 3841-3847
   Abstract »    Full Text »    PDF »
Factors regulating the transcriptional elongation activity of RNA polymerase II.
A. Shilatifard (1998)
FASEB J 12, 1437-1446
   Abstract »    Full Text »
Mechanism of Action of RNA Polymerase II Elongation Factor Elongin. MAXIMAL STIMULATION OF ELONGATION REQUIRES CONVERSION OF THE EARLY ELONGATION COMPLEX TO AN ELONGIN-ACTIVABLE FORM.
R. J. Moreland, J. S. Hanas, J. W. Conaway, and R. C. Conaway (1998)
J. Biol. Chem. 273, 26610-26617
   Abstract »    Full Text »    PDF »
Template End-to-End Transposition by RNA Polymerase II.
M. G. Izban, M. A. Parsons, and R. R. Sinden (1998)
J. Biol. Chem. 273, 27009-27016
   Abstract »    Full Text »    PDF »
Mutations in RNA Polymerase II and Elongation Factor SII Severely Reduce mRNA Levels in Saccharomyces cerevisiae.
J. C. Lennon III, M. Wind, L. Saunders, M. B. Hock, and D. Reines (1998)
Mol. Cell. Biol. 18, 5771-5779
   Abstract »    Full Text »
The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.
X.-Y. Li and M. R Green (1998)
Genes & Dev. 12, 2992-2996
   Abstract »    Full Text »
ABI-1, a Human Homolog to Mouse Abl-Interactor 1, Fuses the MLL Gene in Acute Myeloid Leukemia With t(10;11)(p11.2;q23).
T. Taki, N. Shibuya, M. Taniwaki, R. Hanada, K. Morishita, F. Bessho, M. Yanagisawa, and Y. Hayashi (1998)
Blood 92, 1125-1130
   Abstract »    Full Text »    PDF »
Identification and Purification of the Holo-ELL Complex. EVIDENCE FOR THE PRESENCE OF ELL-ASSOCIATED PROTEINS THAT SUPPRESS THE TRANSCRIPTIONAL INHIBITORY ACTIVITY OF ELL.
A. Shilatifard (1998)
J. Biol. Chem. 273, 11212-11217
   Abstract »    Full Text »    PDF »
Overexpression of the MEN/ELL Protein, an RNA Polymerase II Elongation Factor, Results in Transformation of Rat1 Cells with Dependence on the Lysine-rich Region.
Y. Kanda, K. Mitani, M. Kurokawa, T. Yamagata, Y. Yazaki, and H. Hirai (1998)
J. Biol. Chem. 273, 5248-5252
   Abstract »    Full Text »    PDF »
The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX.
R. K. Slany, C. Lavau, and M. L. Cleary (1998)
Mol. Cell. Biol. 18, 122-129
   Abstract »    Full Text »
RNA Polymerase II Elongation Control.
J. PENG, M. LIU, J. MARION, Y. ZHU, and D.H. PRICE (1998)
Cold Spring Harb Symp Quant Biol 63, 365-370
   Abstract »    PDF »
Fifty Years of Studies of the Biology and Therapy of Childhood Leukemia.
J. H. Kersey (1997)
Blood 90, 4243-4251
   Full Text »    PDF »
Identification of the Region in Yeast S-II That Defines Species Specificity in Its Interaction with RNA Polymerase II.
M. Shimoaraiso, T. Nakanishi, T. Kubo, and S. Natori (1997)
J. Biol. Chem. 272, 26550-26554
   Abstract »    Full Text »    PDF »
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro.
Y. Zhu, T. Pe'ery, J. Peng, Y. Ramanathan, N. Marshall, T. Marshall, B. Amendt, M. B. Mathews, and D. H. Price (1997)
Genes & Dev. 11, 2622-2632
   Abstract »    Full Text »    PDF »
The H3/H4 Tetramer Blocks Transcript Elongation by RNA Polymerase II in Vitro.
C.-H. Chang and D. S. Luse (1997)
J. Biol. Chem. 272, 23427-23434
   Abstract »    Full Text »    PDF »
Translational repression by a transcriptional elongation factor.
H. R. Wilson, L. Kameyama, J.-g. Zhou, G. Guarneros, and D. L. Court (1997)
Genes & Dev. 11, 2204-2213
   Abstract »    Full Text »    PDF »
Structure and Function of RNA Polymerase II Elongation Factor ELL. IDENTIFICATION OF TWO OVERLAPPING ELL FUNCTIONAL DOMAINS THAT GOVERN ITS INTERACTION WITH POLYMERASE AND THE TERNARY ELONGATION COMPLEX.
A. Shilatifard, D. Haque, R. C. Conaway, and J. W. Conaway (1997)
J. Biol. Chem. 272, 22355-22363
   Abstract »    Full Text »    PDF »
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
O. M. Sobulo, J. Borrow, R. Tomek, S. Reshmi, A. Harden, B. Schlegelberger, D. Housman, N. A. Doggett, J. D. Rowley, and N. J. Zeleznik-Le (1997)
PNAS 94, 8732-8737
   Abstract »    Full Text »    PDF »
The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene.
T. Taki, M. Sako, M. Tsuchida, and Y. Hayashi (1997)
Blood 89, 3945-3950
   Abstract »    Full Text »    PDF »
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
A. Shilatifard, D. R. Duan, D. Haque, C. Florence, W. H. Schubach, J. W. Conaway, and R. C. Conaway (1997)
PNAS 94, 3639-3643
   Abstract »    Full Text »    PDF »
EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.
C. W. So, C. Caldas, M.-M. Liu, S.-J. Chen, Q.-H. Huang, L.-J. Gu, M. H. Sham, L. M. Wiedemann, and L. C. Chan (1997)
PNAS 94, 2563-2568
   Abstract »    Full Text »    PDF »
Developmental analysis and subcellular localization of the murine homologue of ELL.
M. J. Thirman, E. B. Diskin, S. S. Bin, H. S. Ip, J. M. Miller, and M. C. Simon (1997)
PNAS 94, 1408-1413
   Abstract »    Full Text »    PDF »
Characterization of Elongin C Functional Domains Required for Interaction with Elongin B and Activation of Elongin A.
Y. Takagi, R. C. Conaway, and J. W. Conaway (1996)
J. Biol. Chem. 271, 25562-25568
   Abstract »    Full Text »    PDF »
Structure of a Conserved Domain Common to the Transcription Factors TFIIS, Elongin A, and CRSP70.
V. Booth, C. M. Koth, A. M. Edwards, and C. H. Arrowsmith (2000)
J. Biol. Chem. 275, 31266-31268
   Abstract »    Full Text »    PDF »
Participation of Transcription Elongation Factor XSII-K1 in Mesoderm-derived Tissue Development in Xenopus laevis.
Y. Taira, T. Kubo, and S. Natori (2000)
J. Biol. Chem. 275, 32011-32015
   Abstract »    Full Text »    PDF »
Identification, Cloning, Expression, and Biochemical Characterization of the Testis-specific RNA Polymerase II Elongation Factor ELL3.
T. Miller, K. Williams, R. W. Johnstone, and A. Shilatifard (2000)
J. Biol. Chem. 275, 32052-32056
   Abstract »    Full Text »    PDF »
Functional Competition between Poly(ADP-ribose) Polymerase and Its 24-kDa Apoptotic Fragment in DNA Repair and Transcription.
T. M. C. Yung and M. S. Satoh (2001)
J. Biol. Chem. 276, 11279-11286
   Abstract »    Full Text »    PDF »
Cloning and Characterization of ELL-associated Proteins EAP45 and EAP20. A ROLE FOR YEAST EAP-LIKE PROTEINS IN REGULATION OF GENE EXPRESSION BY GLUCOSE.
T. Kamura, D. Burian, H. Khalili, S. L. Schmidt, S. Sato, W.-J. Liu, M. N. Conrad, R. C. Conaway, J. W. Conaway, and A. Shilatifard (2001)
J. Biol. Chem. 276, 16528-16533
   Abstract »    Full Text »    PDF »
Transcription Factors TFIIF, ELL, and Elongin Negatively Regulate SII-induced Nascent Transcript Cleavage by Non-arrested RNA Polymerase II Elongation Intermediates.
B. J. Elmendorf, A. Shilatifard, Q. Yan, J. W. Conaway, and R. C. Conaway (2001)
J. Biol. Chem. 276, 23109-23114
   Abstract »    Full Text »    PDF »
Transcription Elongation Factor S-II Confers Yeast Resistance to 6-Azauracil by Enhancing Expression of the SSM1 Gene.
M. Shimoaraiso, T. Nakanishi, T. Kubo, and S. Natori (2000)
J. Biol. Chem. 275, 29623-29627
   Abstract »    Full Text »    PDF »
Panhandle PCR for cDNA: A rapid method for isolation of MLL fusion transcripts involving unknown partner genes.
M. D. Megonigal, E. F. Rappaport, R. B. Wilson, D. H. Jones, J. A. Whitlock, J. A. Ortega, D. J. Slater, P. C. Nowell, and C. A. Felix (2000)
PNAS 97, 9597-9602
   Abstract »    Full Text »    PDF »
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.
S. Vispe, T. M. C. Yung, J. Ritchot, H. Serizawa, and M. S. Satoh (2000)
PNAS 97, 9886-9891
   Abstract »    Full Text »    PDF »
Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.
C. Lavau, R. T. Luo, C. Du, and M. J. Thirman (2000)
PNAS 97, 10984-10989
   Abstract »    Full Text »    PDF »
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein.
T. Miller, N. J. Krogan, J. Dover, H. Erdjument-Bromage, P. Tempst, M. Johnston, J. F. Greenblatt, and A. Shilatifard (2001)
PNAS 98, 12902-12907
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)