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Science 22 March 1996:
Vol. 271. no. 5256, pp. 1726 - 1728
DOI: 10.1126/science.271.5256.1726
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Reports

Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus

Marcella Sarzotti, * Deanna S. Robbins, Paul M. Hoffman

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

M. Sarzotti, Research Service, Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
D. S. Robbins, Research Service, Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA, and Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
P. M. Hoffman, Research Service, Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA, and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
* To whom correspondence should be addressed. E-mail: msarzott{at}umabnet.ab.umd.edu


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   Abstract »    Full Text »    PDF »
Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes.
A. Le Campion, C. Bourgeois, F. Lambolez, B. Martin, S. Leaument, N. Dautigny, C. Tanchot, C. Penit, and B. Lucas (2002)
PNAS 99, 4538-4543
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Science. ISSN 0036-8075 (print), 1095-9203 (online)