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Science 22 March 1996:
Vol. 271. no. 5256, pp. 1723 - 1726
DOI: 10.1126/science.271.5256.1723
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Reports

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

John Paul Ridge, * Ephraim J. Fuchs, dagger Polly Matzinger

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

Section on T Cell Tolerance and Memory (Ghost Lab), Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
* To whom correspondence should be addressed.
dagger Present address: Johns Hopkins Oncology Center, Baltimore, MD 21287, USA.


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J. Immunol. 165, 1725-1728
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Antigen-Specific Responses to Diphtheria-Tetanus-Acellular Pertussis Vaccine in Human Infants Are Initially Th2 Polarized.
J. Rowe, C. Macaubas, T. M. Monger, B. J. Holt, J. Harvey, J. T. Poolman, P. D. Sly, and P. G. Holt (2000)
Infect. Immun. 68, 3873-3877
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The Thyrotropin (Thyroid-Stimulating Hormone) Receptor Is Expressed on Murine Dendritic Cells and on a Subset of CD45RBhigh Lymph Node T Cells: Functional Role for Thyroid-Stimulating Hormone During Immune Activation.
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J. Immunol. 164, 6158-6165
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Sustained Expression of CD154 (CD40L) and Proinflammatory Cytokine Production by Alloantigen-Stimulated Umbilical Cord Blood T Cells.
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J. Immunol. 164, 6206-6212
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Polyomavirus-Infected Dendritic Cells Induce Antiviral CD8+ T Lymphocytes.
D. R. Drake III, J. M. Moser, A. Hadley, J. D. Altman, C. Maliszewski, E. Butz, and A. E. Lukacher (2000)
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Neonatal Administration of IL-12 Enhances the Protective Efficacy of Antiviral Vaccines.
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   Abstract »    Full Text »    PDF »
Newborns Develop a Th1-Type Immune Response to Mycobacterium bovis Bacillus Calmette-Guerin Vaccination.
A. Marchant, T. Goetghebuer, M. O. Ota, I. Wolfe, S. J. Ceesay, D. De Groote, T. Corrah, S. Bennett, J. Wheeler, K. Huygen, et al. (1999)
J. Immunol. 163, 2249-2255
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Cutting Edge: CD40 Ligand Is a Limiting Factor in the Humoral Response to T Cell-Dependent Antigens.
M. Perez-Melgosa, D. Hollenbaugh, and C. B. Wilson (1999)
J. Immunol. 163, 1123-1127
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Anergy and Cytokine-mediated Suppression as Distinct Superantigen-induced Tolerance Mechanisms In Vivo.
C. Miller, J. A. Ragheb, and R. H. Schwartz (1999)
J. Exp. Med. 190, 53-64
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Expansion of neonatal tolerance to self in adult life: I. The role of a bacterial adjuvant in tolerance spread.
N. Grabie, I. Wohl, S. Youssef, G. Wildbaum, and N. Karin (1999)
Int. Immunol. 11, 899-906
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Expansion of neonatal tolerance to self in adult life: II. Tolerance preferentially spreads in an intramolecular manner.
N. Grabie and N. Karin (1999)
Int. Immunol. 11, 907-913
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Antigen-Specific T Cell Activation and Proliferation During Oral Tolerance Induction.
J. Sun, B. Dirden-Kramer, K. Ito, P. B. Ernst, and N. Van Houten (1999)
J. Immunol. 162, 5868-5875
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