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Science 15 March 1996:
Vol. 271. no. 5255, pp. 1589 - 1592
DOI: 10.1126/science.271.5255.1589
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Reports

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

Theresa M. Klauck, * Maree C. Faux, * Kirstin Labudda, Lorene K. Langeberg, Susan Jaken, John D. Scott dagger

Multivalent binding proteins, such as the yeast scaffold protein Sterile-5, coordinate the location of kinases by serving as platforms for the assembly of signaling units. Similarly, in mammalian cells the cyclic adenosine 3',5'-monophosphate-dependent protein kinase (PKA) and phosphatase 2B [calcineurin (CaN)] are complexed by an A kinase anchoring protein, AKAP79. Deletion analysis and binding studies demonstrate that a third enzyme, protein kinase C (PKC), binds AKAP79 at a site distinct from those bound by PKA or CaN. The subcellular distributions of PKC and AKAP79 were similar in neurons. Thus, AKAP79 appears to function as a scaffold protein for three multifunctional enzymes.

T. M. Klauck, M. C. Faux, K. Labudda, L. K. Langeberg, J. D. Scott, Vollum Institute, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201, USA.
S. Jaken, W. Alton Jones Cell Science Center, 10 Old Barn Road, Lake Placid, NY 12946 USA.
* These authors contributed equally to this manuscript.
dagger To whom correspondence should be addressed.


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S. Vijayaraghavan, G. A. Liberty, J. Mohan, V. P. Winfrey, G. E. Olson, and D. W. Carr (1999)
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   Abstract »    Full Text »
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers.
H. J. Schaeffer and M. J. Weber (1999)
Mol. Cell. Biol. 19, 2435-2444
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Type II cAMP-dependent protein kinase regulates electrogenic ion transport in rabbit collecting duct.
Z. Qi, C.-M. Hao, K. Salter, R. Redha, and M. D. Breyer (1999)
Am J Physiol Renal Physiol 276, F622-F628
   Abstract »    Full Text »    PDF »
Effect of Fever-Like Whole-Body Hyperthermia on Lymphocyte Spectrin Distribution, Protein Kinase C Activity, and Uropod Formation.
X.-Y. Wang, J. R. Ostberg, and E. A. Repasky (1999)
J. Immunol. 162, 3378-3387
   Abstract »    Full Text »    PDF »
Cell Cycle and Hormonal Control of Nuclear-Cytoplasmic Localization of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, in Mammary Tumor Cells. A NOVEL CONVERGENCE POINT OF ANTI-PROLIFERATIVE AND PROLIFERATIVE CELL SIGNALING PATHWAYS.
P. Buse, S. H. Tran, E. Luther, P. T. Phu, G. W. Aponte, and G. L. Firestone (1999)
J. Biol. Chem. 274, 7253-7263
   Abstract »    Full Text »    PDF »
AKAP350, a Multiply Spliced Protein Kinase A-anchoring Protein Associated with Centrosomes.
P. H. Schmidt, D. T. Dransfield, J. O. Claudio, R. G. Hawley, K. W. Trotter, S. L. Milgram, and J. R. Goldenring (1999)
J. Biol. Chem. 274, 3055-3066
   Abstract »    Full Text »    PDF »
Dynamic Complexes of beta 2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin.
M. Shih, F. Lin, J. D. Scott, H.-y. Wang, and C. C. Malbon (1999)
J. Biol. Chem. 274, 1588-1595
   Abstract »    Full Text »    PDF »
Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A.
R. S. Westphal, R. L. Coffee Jr., A. Marotta, S. L. Pelech, and B. E. Wadzinski (1999)
J. Biol. Chem. 274, 687-692
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Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells.
P. Nelson, K Moissoglu, J Vargas, P. Klotman, and I. Gelman (1999)
J. Cell Sci. 112, 361-370
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Dimerization/Docking Domain of the Type Ialpha Regulatory Subunit of cAMP-dependent Protein Kinase. REQUIREMENTS FOR DIMERIZATION AND DOCKING ARE DISTINCT BUT OVERLAPPING.
P. Banky, L. J.-S. Huang, and S. S. Taylor (1998)
J. Biol. Chem. 273, 35048-35055
   Abstract »    Full Text »    PDF »
An X-linked Gene Encodes a Major Human Sperm Fibrous Sheath Protein, hAKAP82. GENOMIC ORGANIZATION, PROTEIN KINASE A-RII BINDING, AND DISTRIBUTION OF THE PRECURSOR IN THE SPERM TAIL.
R. M. O. Turner, L. R. Johnson, L. Haig-Ladewig, G. L. Gerton, and S. B. Moss (1998)
J. Biol. Chem. 273, 32135-32141
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AKAP79 Inhibits Calcineurin through a Site Distinct from the Immunophilin-binding Region.
A. Kashishian, M. Howard, C. Loh, W. M. Gallatin, M. F. Hoekstra, and Y. Lai (1998)
J. Biol. Chem. 273, 27412-27419
   Abstract »    Full Text »    PDF »
Evidence That Protein Kinase Cepsilon Mediates Phorbol Ester Inhibition of Calphostin C- and Tumor Necrosis Factor-alpha -induced Apoptosis in U937 Histiocytic Lymphoma Cells.
G. C. Mayne and A. W. Murray (1998)
J. Biol. Chem. 273, 24115-24121
   Abstract »    Full Text »    PDF »


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