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Science 15 March 1996:
Vol. 271. no. 5255, pp. 1586 - 1589
DOI: 10.1126/science.271.5255.1586
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Reports

Opposite Modulation of Cocaine-Seeking Behavior by D1- and D2-Like Dopamine Receptor Agonists

David W. Self, * William J. Barnhart, David A. Lehman, Eric J. Nestler

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this ``priming'' effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, CT 06508, USA.
* To whom correspondence should be addressed.


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Molecular Mechanisms of Cocaine Addiction.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)