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Science 8 March 1996:
Vol. 271. no. 5254, p. 1341
DOI:

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After blood vessels are injured, a number of growth factor genes are induced that help direct tissue repair, but the molecular signals that initiate this process have yet to be identified. Khachigian et al. (p. 1427) show that after injury to the rat aorta, there is a marked increase in the expression of the transcription factor early-growth-response gene product (Egr-1) at the wound edge. They find that Egr-1 interacts with the proximal promoter for the platelet-derived growth factor B-chain (PDGF-B) gene and displaces the transcription factor Sp1, whose site overlaps that for Egr-1. Putative recognition elements for Egr-1 have been identified for other genes that are activated upon injury, which suggests that Egr-1 may be involved generally in the activation of pathophysiological factors after arterial injury.




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