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Science 1 March 1996:
Vol. 271. no. 5253, pp. 1245 - 1246
DOI: 10.1126/science.271.5253.1245
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Perspectives

Kathleen S. Matthews

The lactose repressor turns the bacterial genes for lactose metabolism on and off. This system has served as a blueprint for the study of both eukaryotic and prokaryotic gene regulation for decades. In this issue of Science, the crystal structure of the whole lactose repressor in a complex with DNA and its inducer is reported. In her Perspective, K. Matthews discusses the significance of this landmark event.

The author is in the Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77251, USA. E-mail: ksm@bioc.rice.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Crystal Structure of the Sugar Binding Domain of the Archaeal Transcriptional Regulator TrmB.
M. Krug, S.-J. Lee, K. Diederichs, W. Boos, and W. Welte (2006)
J. Biol. Chem. 281, 10976-10982
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Regulatory Network of Escherichia coli: Consistency Between Literature Knowledge and Microarray Profiles.
R. M. Gutierrez-Rios, D. A. Rosenblueth, J. A. Loza, A. M. Huerta, J. D. Glasner, F. R. Blattner, and J. Collado-Vides (2003)
Genome Res. 13, 2435-2443
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Science. ISSN 0036-8075 (print), 1095-9203 (online)