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Science 23 February 1996:
Vol. 271. no. 5252, pp. 1081 - 1085
DOI: 10.1126/science.271.5252.1081
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Articles

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

Jeremy M. Berg (1) and Yigong Shi

Zinc ions are key structural components of a large number of proteins. The binding of zinc stabilizes the folded conformations of domains so that they may facilitate interactions between the proteins and other macromolecules such as DNA. The modular nature of some of these zinc-containing proteins has allowed the rational design of site-specific DNA binding proteins. The ability of zinc to be bound specifically within a range of tetrahedral sites appears to be responsible for the evolution of the wide range of zinc-stabilized structural domains now known to exist. The lack of redox activity for the zinc ion and its binding and exchange kinetics also may be important in the use of zinc for specific functional roles.

The authors are in the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
(1) To whom correspondence should be addressed.


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Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.
X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
   Abstract »    Full Text »
Zinc Stoichiometry of Yeast RNA Polymerase II and Characterization of Mutations in the Zinc-binding Domain of the Largest Subunit.
I. M. Donaldson and J. D. Friesen (2000)
J. Biol. Chem. 275, 13780-13788
   Abstract »    Full Text »    PDF »
A Novel Gibberellin-Induced Gene from Rice and Its Potential Regulatory Role in Stem Growth.
E. van der Knaap, J. H. Kim, and H. Kende (2000)
Plant Physiology 122, 695-704
   Abstract »    Full Text »    PDF »
Functional Expression of the Human hZIP2 Zinc Transporter.
L. A. Gaither and D. J. Eide (2000)
J. Biol. Chem. 275, 5560-5564
   Abstract »    Full Text »    PDF »
The sigma 70 Transcription Factor TyrR Has Zinc-Stimulated Phosphatase Activity That Is Inhibited by ATP and Tyrosine.
S. Zhao, Q. Zhu, and R. L. Somerville (2000)
J. Bacteriol. 182, 1053-1061
   Abstract »    Full Text »
A Cysteine-Rich Motif in Poliovirus Protein 2CATPase Is Involved in RNA Replication and Binds Zinc In Vitro.
T. Pfister, K. W. Jones, and E. Wimmer (2000)
J. Virol. 74, 334-343
   Abstract »    Full Text »
NeSL-1, an Ancient Lineage of Site-Specific Non-LTR Retrotransposons From Caenorhabditis elegans.
H. S. Malik and T. H. Eickbush (2000)
Genetics 154, 193-203
   Abstract »    Full Text »
DNA Distortion Mechanism for Transcriptional Activation by ZntR, a Zn(II)-responsive MerR Homologue in Escherichia coli.
C. E. Outten, F. W. Outten, and T. V. O'Halloran (1999)
J. Biol. Chem. 274, 37517-37524
   Abstract »    Full Text »    PDF »
Lead Inhibition of DNA-Binding Mechanism of Cys2His2 Zinc Finger Proteins.
J. S. Hanas, J. S. Rodgers, J. A. Bantle, and Y.-G. Cheng (1999)
Mol. Pharmacol. 56, 982-988
   Abstract »    Full Text »
Structure-based design of an RNA-binding zinc finger.
D. J. McColl, C. D. Honchell, and A. D. Frankel (1999)
PNAS 96, 9521-9526
   Abstract »    Full Text »    PDF »
NK Lytic-Associated Molecule: A Novel Gene Selectively Expressed in Cells with Cytolytic Function.
M. Kozlowski, J. Schorey, T. Portis, V. Grigoriev, and J. Kornbluth (1999)
J. Immunol. 163, 1775-1785
   Abstract »    Full Text »    PDF »


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