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Science 2 February 1996:
Vol. 271. no. 5249, p. 617
DOI: 10.1126/science.271.5249.617
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Perspectives

Stella M. Hurtley

Cytosolic proteins are tagged with the polypeptide ubiquitin for eventual destruction by the proteasome. A recent paper in Cell (L. Hicke and H. Riezman, vol. 84, p. 277) shows that in yeast ubiquitin also serves to tag membrane proteins for degradation by proteases in the vacuole, the yeast equivalent of the lysosome.

The author is an Associate Editor of Science at the Europe Office, Cambridge, UK.


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