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Science 26 January 1996:
Vol. 271. no. 5248, pp. 518 - 520
DOI: 10.1126/science.271.5248.518
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Reports

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

Susan Acton (1),  Attilio Rigotti,  Katherine T. Landschulz,  Shangzhe Xu,  Helen H. Hobbs,  Monty Krieger (2)

High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.


S. Acton, A. Rigotti, S. Xu, M. Krieger, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
K. T. Landschulz and H. H. Hobbs, Departments of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
(1) Present address: Millennium Pharmaceuticals, Cambridge, MA 02139, USA.
(2) To whom correspondence should be addressed.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
M. Y. Choi, A. I. Romer, M. Hu, M. Lepourcelet, A. Mechoor, A. Yesilaltay, M. Krieger, P. A. Gray, and R. A. Shivdasani (2006)
Development 133, 4119-4129
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PDZK1 Is Required for Maintaining Hepatic Scavenger Receptor, Class B, Type I (SR-BI) Steady State Levels but Not Its Surface Localization or Function.
A. Yesilaltay, O. Kocher, R. Pal, A. Leiva, V. Quinones, A. Rigotti, and M. Krieger (2006)
J. Biol. Chem. 281, 28975-28980
   Abstract »    Full Text »    PDF »
Sorting Out The Complexities of Reverse Cholesterol Transport: CETP Polymorphisms, HDL, and Coronary Disease..
S. Fazio and M. F. Linton (2006)
J. Clin. Endocrinol. Metab. 91, 3273-3275
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Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts.
B. Sun, E. R. M. Eckhardt, S. Shetty, D. R. van der Westhuyzen, and N. R. Webb (2006)
J. Lipid Res. 47, 1700-1713
   Abstract »    Full Text »    PDF »
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake.
K. J. Moore and M. W. Freeman (2006)
Arterioscler Thromb Vasc Biol 26, 1702-1711
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Hepatic ATP-Binding Cassette Transporter A1 Is a Key Molecule in High-Density Lipoprotein Cholesteryl Ester Metabolism in Mice.
R. R. Singaraja, B. Stahmer, M. Brundert, M. Merkel, J. Heeren, N. Bissada, M. Kang, J. M. Timmins, R. Ramakrishnan, J. S. Parks, et al. (2006)
Arterioscler Thromb Vasc Biol 26, 1821-1827
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Aspirin regulates expression and function of scavenger receptor-BI in macrophages: studies in primary human macrophages and in mice.
I. Tancevski, A. Wehinger, W. Schgoer, P. Eller, S. Cuzzocrea, B. Foeger, J. R. Patsch, and A. Ritsch (2006)
FASEB J 20, 1328-1335
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Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.
J. Dong, J. Liu, B. Lou, Z. Li, X. Ye, M. Wu, and X.-C. Jiang (2006)
J. Lipid Res. 47, 1307-1314
   Abstract »    Full Text »    PDF »
Hepatitis C virus entry: potential receptors and their biological functions..
L. Cocquerel, C. Voisset, and J. Dubuisson (2006)
J. Gen. Virol. 87, 1075-1084
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Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.
C. Xie, J. A. Richardson, S. D. Turley, and J. M. Dietschy (2006)
J. Lipid Res. 47, 953-963
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SR-BI-mediated High Density Lipoprotein (HDL) Endocytosis Leads to HDL Resecretion Facilitating Cholesterol Efflux.
T. A. Pagler, S. Rhode, A. Neuhofer, H. Laggner, W. Strobl, C. Hinterndorfer, I. Volf, M. Pavelka, E. R. M. Eckhardt, D. R. van der Westhuyzen, et al. (2006)
J. Biol. Chem. 281, 11193-11204
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Scavenger Receptor BI Prevents Nitric Oxide-Induced Cytotoxicity and Endotoxin-Induced Death.
X.-A. Li, L. Guo, R. Asmis, M. Nikolova-Karakashian, and E. J. Smart (2006)
Circ. Res. 98, e60-e65
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A liver-high-density lipoprotein-ovarian axis of fertility..
A. D. Attie (2006)
Endocrinology 147, 1575-1576
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Overexpression of estrogen receptor {alpha} increases hepatic cholesterogenesis, leading to biliary hypersecretion in mice.
H. H. Wang, N. H. Afdhal, and D. Q-H. Wang (2006)
J. Lipid Res. 47, 778-786
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Effects of Hepatic Expression of the High-Density Lipoprotein Receptor SR-BI on Lipoprotein Metabolism and Female Fertility.
A. Yesilaltay, M. G. Morales, L. Amigo, S. Zanlungo, A. Rigotti, S. L. Karackattu, M. H. Donahee, K. F. Kozarsky, and M. Krieger (2006)
Endocrinology 147, 1577-1588
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Effect of Inhibiting Cholesteryl Ester Transfer Protein on the Kinetics of High-Density Lipoprotein Cholesteryl Ester Transport in Plasma: In Vivo Studies in Rabbits.
P. Kee, D. Caiazza, K.-A. Rye, P.H.R. Barrett, L.A. Morehouse, and P.J. Barter (2006)
Arterioscler Thromb Vasc Biol 26, 884-890
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Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI.
F. Bietrix, D. Yan, M. Nauze, C. Rolland, J. Bertrand-Michel, C. Comera, S. Schaak, R. Barbaras, A. K. Groen, B. Perret, et al. (2006)
J. Biol. Chem. 281, 7214-7219
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Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy.
C. J. Harder, G. Vassiliou, H. M. McBride, and R. McPherson (2006)
J. Lipid Res. 47, 492-503
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Multiple Hepatic Receptors Cooperate to Eliminate Secretory Mucins Aberrantly Entering the Bloodstream: Are Circulating Cancer Mucins the "Tip of the Iceberg"?.
M. G. Wahrenbrock and A. Varki (2006)
Cancer Res. 66, 2433-2441
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Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences.
N. D. Vaziri (2006)
Am J Physiol Renal Physiol 290, F262-F272
   Abstract »    Full Text »    PDF »


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