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Science 22 December 1995:
Vol. 270. no. 5244, pp. 2008 - 2011
DOI: 10.1126/science.270.5244.2008
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Reports

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF- Signal Transduction

Kyoko Yamaguchi,  Kyoko Shirakabe,  Hiroshi Shibuya (1),  Kenji Irie (1),  Isao Oishi,  Naoto Ueno,  Tadatsugu Taniguchi,  Eisuke Nishida,  Kunihiro Matsumoto

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-beta (TGF-beta). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-beta superfamily members.


K. Yamaguchi, K. Irie, K. Matsumoto, Department of Molecular Biology, Faculty of Science, Nagoya University, Chikusa-ku, Nagoya 464-01, Japan.
K. Shirakabe and E. Nishida, Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan.
H. Shibuya and N. Ueno, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan.
I. Ohishi and T. Taniguchi, Institute for Molecular and Cellular Biology, Osaka University, Suita-shi, Osaka 565, Japan.
(1) To whom correspondence should be addressed.


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   Abstract »    Full Text »    PDF »
Vascular Endothelial Cell Growth Factor Attenuates Actions of Transforming Growth Factor-{beta} in Human Endothelial Cells.
K. Yamauchi, Y. Nishimura, S. Shigematsu, Y. Takeuchi, J. Nakamura, T. Aizawa, and K. Hashizume (2004)
J. Biol. Chem. 279, 55104-55108
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VIAF, a Conserved Inhibitor of Apoptosis (IAP)-interacting Factor That Modulates Caspase Activation.
J. C. Wilkinson, B. W. M. Richter, A. S. Wilkinson, E. Burstein, J. M. Rumble, B. Balliu, and C. S. Duckett (2004)
J. Biol. Chem. 279, 51091-51099
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Protein Phosphatase 4 Is a Positive Regulator of Hematopoietic Progenitor Kinase 1.
G. Zhou, J. S. Boomer, and T.-H. Tan (2004)
J. Biol. Chem. 279, 49551-49561
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TGF-{beta} SIGNAL TRANSDUCTION IN ORO-FACIAL HEALTH AND NON-MALIGNANT DISEASE (PART I).
S.S. Prime, M. Pring, M. Davies, and I.C. Paterson (2004)
Critical Reviews in Oral Biology & Medicine 15, 324-336
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Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides.
J. W. Bullen Jr, M. Ziotopoulou, L. Ungsunan, J. Misra, I. Alevizos, E. Kokkotou, E. Maratos-Flier, G. Stephanopoulos, and C. S. Mantzoros (2004)
Am J Physiol Endocrinol Metab 287, E662-E670
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Characterization of the Bone Morphogenetic Protein (BMP) System in Human Pulmonary Arterial Smooth Muscle Cells Isolated from a Sporadic Case of Primary Pulmonary Hypertension: Roles of BMP Type IB Receptor (Activin Receptor-Like Kinase-6) in the Mitotic Action.
M. Takeda, F. Otsuka, K. Nakamura, K. Inagaki, J. Suzuki, D. Miura, H. Fujio, H. Matsubara, H. Date, T. Ohe, et al. (2004)
Endocrinology 145, 4344-4354
   Abstract »    Full Text »    PDF »
Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-{beta}1 in human airway epithelial cells.
N. S. Undevia, D. R. Dorscheid, B. A. Marroquin, W. L. Gugliotta, R. Tse, and S. R. White (2004)
Am J Physiol Lung Cell Mol Physiol 287, L515-L524
   Abstract »    Full Text »    PDF »
Differential Activation of Smads in HeLa and SiHa Cells That Differ in Their Response to Transforming Growth Factor-{beta}.
T. T. Maliekal, R. J. Anto, and D. Karunagaran (2004)
J. Biol. Chem. 279, 36287-36292
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Activation Mechanism of c-Jun Amino-terminal Kinase in the Course of Neural Differentiation of P19 Embryonic Carcinoma Cells.
S. Akiyama, T. Yonezawa, T.-a. Kudo, M. G. Li, H. Wang, M. Ito, K. Yoshioka, J. Ninomiya-Tsuji, K. Matsumoto, R. Kanamaru, et al. (2004)
J. Biol. Chem. 279, 36616-36620
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TGF-{beta}1 and angiotensin networking in cardiac remodeling.
S. Rosenkranz (2004)
Cardiovasc Res 63, 423-432
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Roles of MAP Kinase Cascades in Caenorhabditis elegans.
A. Sakaguchi, K. Matsumoto, and N. Hisamoto (2004)
J. Biochem. 136, 7-11
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Reciprocal Cross-talk between Nod2 and TAK1 Signaling Pathways.
C.-M. Chen, Y. Gong, M. Zhang, and J.-J. Chen (2004)
J. Biol. Chem. 279, 25876-25882
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Wnt Activates the Tak1/Nemo-like Kinase Pathway.
L. Smit, A. Baas, J. Kuipers, H. Korswagen, M. van de Wetering, and H. Clevers (2004)
J. Biol. Chem. 279, 17232-17240
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Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.
C. Kanei-Ishii, J. Ninomiya-Tsuji, J. Tanikawa, T. Nomura, T. Ishitani, S. Kishida, K. Kokura, T. Kurahashi, E. Ichikawa-Iwata, Y. Kim, et al. (2004)
Genes & Dev. 18, 816-829
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Activin A in the Regulation of Corneal Neovascularization and Vascular Endothelial Growth Factor Expression.
V. Poulaki, N. Mitsiades, F. E. Kruse, S. Radetzky, E. Iliaki, B. Kirchhof, and A. M. Joussen (2004)
Am. J. Pathol. 164, 1293-1302
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Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein.
J. S. Park, D. Svetkauskaite, Q. He, J.-Y. Kim, D. Strassheim, A. Ishizaka, and E. Abraham (2004)
J. Biol. Chem. 279, 7370-7377
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Role of the TAK1-NLK-STAT3 pathway in TGF-{beta}-mediated mesoderm induction.
B. Ohkawara, K. Shirakabe, J. Hyodo-Miura, R. Matsuo, N. Ueno, K. Matsumoto, and H. Shibuya (2004)
Genes & Dev. 18, 381-386
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The Bone Morphogenetic Protein System In Mammalian Reproduction.
S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson (2004)
Endocr. Rev. 25, 72-101
   Abstract »    Full Text »    PDF »
Novel Action of Activin and Bone Morphogenetic Protein in Regulating Aldosterone Production by Human Adrenocortical Cells.
J. Suzuki, F. Otsuka, K. Inagaki, M. Takeda, T. Ogura, and H. Makino (2004)
Endocrinology 145, 639-649
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Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis.
D. R. Hammaker, D. L. Boyle, M. Chabaud-Riou, and G. S. Firestein (2004)
J. Immunol. 172, 1612-1618
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Myocardin Expression Is Regulated by Nkx2.5, and Its Function Is Required for Cardiomyogenesis.
T. Ueyama, H. Kasahara, T. Ishiwata, Q. Nie, and S. Izumo (2003)
Mol. Cell. Biol. 23, 9222-9232
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HER2/Neu- and TAK1-mediated Up-regulation of the Transforming Growth Factor {beta} Inhibitor Smad7 via the ETS Protein ER81.
S. C. Dowdy, A. Mariani, and R. Janknecht (2003)
J. Biol. Chem. 278, 44377-44384
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Transforming Growth Factor-{beta}-induced Apoptosis Is Mediated by Smad-dependent Expression of GADD45b through p38 Activation.
J. Yoo, M. Ghiassi, L. Jirmanova, A. G. Balliet, B. Hoffman, A. J. Fornace Jr., D. A. Liebermann, E. P. Bottinger, and A. B. Roberts (2003)
J. Biol. Chem. 278, 43001-43007
   Abstract »    Full Text »    PDF »
Toll-like Receptor Signaling.
S. Akira (2003)
J. Biol. Chem. 278, 38105-38108
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Regulation of apoptosis in theXenopus embryo by Bix3.
M. Trindade, N. Messenger, C. Papin, D. Grimmer, L. Fairclough, M. Tada, and J. C. Smith (2003)
Development 130, 4611-4622
   Abstract »    Full Text »    PDF »
p38 Mitogen-activated protein kinase protects glomerular epithelial cells from complement-mediated cell injury.
L. Aoudjit, M. Stanciu, H. Li, S. Lemay, and T. Takano (2003)
Am J Physiol Renal Physiol 285, F765-F774
   Abstract »    Full Text »    PDF »


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