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Science 15 December 1995:
Vol. 270. no. 5243, pp. 1845 - 1847
DOI: 10.1126/science.270.5243.1845
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Reports

Role of NK1.1+ T Cells in a TH2 Response and in Immunoglobulin E Production

Tomohiro Yoshimoto (1),  Albert Bendelac,  Cynthia Watson,  Jane Hu-Li,  William E. Paul (2)

Immune responses dominated by interleukin-4 (IL-4)-producing T helper type 2 (TH2) cells or by interferon (IFN-)-producing T helper type 1 (TH1) cells express distinctive protection against infection with different pathogens. Interleukin-4 promotes the differentiation of naïve CD4+ T cells into IL-4 producers and suppresses their development into IFN- producers. CD1-specific splenic CD4+NK1.1+ T cells, a numerically minor population, produced IL-4 promptly on in vivo stimulation. This T cell population was essential for the induction of IL-4-producing cells and for switching to immunoglobulin E, an IL-4-dependent event, in response to injection of antibodies to immunoglobulin D.


T. Yoshimoto, C. Watson, J. Hu-Li, W. E. Paul, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
A. Bendelac, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
(1) Present address: Department of Immunology and Medical Zoology, Hyogo College of Medicine, 1-1, Mukogawa, Nishinomiya 663, Japan.
(2) To whom correspondence should be addressed.


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J. Immunol. 162, 4560-4566
   Abstract »    Full Text »    PDF »
The Natural Killer T (NKT) Cell Ligand {alpha}-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells.
H. Kitamura, K. Iwakabe, T. Yahata, S.-i. Nishimura, A. Ohta, Y. Ohmi, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, et al. (1999)
J. Exp. Med. 189, 1121-1128
   Abstract »    Full Text »    PDF »
Biochemical Characterization of CD1d Expression in the Absence of beta 2-Microglobulin.
H. S. Kim, J. Garcia, M. Exley, K. W. Johnson, S. P. Balk, and R. S. Blumberg (1999)
J. Biol. Chem. 274, 9289-9295
   Abstract »    Full Text »    PDF »
Marking IL-4-producing cells by knock-in of the IL-4 gene.
I-C. Ho, M. H. Kaplan, L. Jackson-Grusby, L. H. Glimcher, and M. J. Grusby (1999)
Int. Immunol. 11, 243-247
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MHC Class II-Dependent NK1.1+ {gamma}{delta} T Cells Are Induced in Mice by Salmonella Infection.
H. Nishimura, J. Washizu, Y. Naiki, T. Hara, Y. Fukui, T. Sasazuki, and Y. Yoshikai (1999)
J. Immunol. 162, 1573-1581
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CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells.
L. Schofield, M. J. McConville, D. Hansen, A. S. Campbell, B. Fraser-Reid, M. J. Grusby, and S. D. Tachado (1999)
Science 283, 225-229
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IL-13 Production by NK Cells: IL-13-Producing NK and T Cells Are Present In Vivo in the Absence of IFN-{gamma}.
T. Hoshino, R. T. Winkler-Pickett, A. T. Mason, J. R. Ortaldo, and H. A. Young (1999)
J. Immunol. 162, 51-59
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Overexpression of Natural Killer T Cells Protects V{alpha}14-J{alpha}281 Transgenic Nonobese Diabetic Mice against Diabetes.
A. Lehuen, O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J.-F. Bach, and R. C. Monteiro (1998)
J. Exp. Med. 188, 1831-1839
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Early IL-4 Induction in Bone Marrow Lymphoid Precursor Cells by Mycobacterial Lipoarabinomannan.
H. L. Collins, U. E. Schaible, and S. H. E. Kaufmann (1998)
J. Immunol. 161, 5546-5554
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CD1d-mediated Recognition of an {alpha}-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution.
L. Brossay, M. Chioda, N. Burdin, Y. Koezuka, G. Casorati, P. Dellabona, and M. Kronenberg (1998)
J. Exp. Med. 188, 1521-1528
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Selective Ability of Mouse CD1 to Present Glycolipids: {alpha}-Galactosylceramide Specifically Stimulates V{alpha}14+ NK T Lymphocytes.
N. Burdin, L. Brossay, Y. Koezuka, S. T. Smiley, M. J. Grusby, M. Gui, M. Taniguchi, K. Hayakawa, and M. Kronenberg (1998)
J. Immunol. 161, 3271-3281
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CD161 (NKR-P1A) Costimulation of CD1d-dependent Activation of Human T Cells Expressing Invariant V{alpha}24J{alpha}Q T Cell Receptor {alpha} Chains.
M. Exley, S. Porcelli, M. Furman, J. Garcia, and S. Balk (1998)
J. Exp. Med. 188, 867-876
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Switch of CD4+ T Cell Differentiation from Th2 to Th1 by Treatment with Cathepsin B Inhibitor in Experimental Leishmaniasis.
Y. Maekawa, K. Himeno, H. Ishikawa, H. Hisaeda, T. Sakai, T. Dainichi, T. Asao, R. A Good, and N. Katunuma (1998)
J. Immunol. 161, 2120-2127
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Mature Mainstream TCR{alpha}{beta}+CD4+ Thymocytes Expressing L-Selectin Mediate ""Active Tolerance"" in the Nonobese Diabetic Mouse.
A. Herbelin, J.-M. Gombert, F. Lepault, J.-F. Bach, and L. Chatenoud (1998)
J. Immunol. 161, 2620-2628
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{beta}2-Microglobulin-Dependent T Cells Are Not Necessary for Alloantigen-Induced Th2 Responses After Neonatal Induction of Lymphoid Chimerism in Mice.
G. Foucras, C. Coureau, L. Beijleveld, P. Druet, A. Saoudi, and J.-C. Guery (1998)
J. Immunol. 161, 1751-1757
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Effective and Long-Lasting Immunity against the Parasite Leishmania major in CD8-Deficient Mice.
M. Huber, E. Timms, T. W. Mak, M. Rollinghoff, and M. Lohoff (1998)
Infect. Immun. 66, 3968-3970
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IL-4-Producing NK1.1+ T Cells Are Resistant to Glucocorticoid-Induced Apoptosis: Implications for the Th1/Th2 Balance.
K. Tamada, M. Harada, K. Abe, T. Li, and K. Nomoto (1998)
J. Immunol. 161, 1239-1247
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LPS-Stimulated SJL Macrophages Produce IL-12 and IL-18 That Inhibit IgE Production In Vitro by Induction of IFN-{gamma} Production from CD3intIL-2R{beta}+ T Cells.
T. Yoshimoto, N. Nagai, K. Ohkusu, H. Ueda, H. Okamura, and K. Nakanishi (1998)
J. Immunol. 161, 1483-1492
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T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.
M. Lohning, A. Stroehmann, A. J. Coyle, J. L. Grogan, S. Lin, J.-C. Gutierrez-Ramos, D. Levinson, A. Radbruch, and T. Kamradt (1998)
PNAS 95, 6930-6935
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A Critical Role for IL-4 in Regulating Disease Severity in Experimental Allergic Encephalomyelitis as Demonstrated in IL-4-Deficient C57BL/6 Mice and BALB/c Mice.
M. Falcone, A. J. Rajan, B. R. Bloom, and C. F. Brosnan (1998)
J. Immunol. 160, 4822-4830
   Abstract »    Full Text »    PDF »


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