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Science 24 November 1995:
Vol. 270. no. 5240, pp. 1360 - 1362
DOI: 10.1126/science.270.5240.1360
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Reports

Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

Ute-Christiane Meier (1),  Paul Klenerman (1),  Philip Griffin,  William James,  Britta Köppe,  Brendan Larder,  Andrew McMichael,  Rodney Phillips (2)

Immune evasion by the human immunodeficiency virus (HIV) is unexplained but may involve the mutation of viral antigens. When cytotoxic T lymphocytes engaged CD4-positive cells that were acutely infected with HIV bearing natural variant epitopes in reverse transcriptase, substantial inhibition of specific antiviral lysis was observed. Mutant viruses capable of these transactive effects could facilitate the persistence of a broad range of HIV variants in the face of an active and specific immune response.


U.-C. Meier, P. Klenerman, B. Köppe, A. McMichael, R. Phillips, Nuffield Department of Clinical Medicine and Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
P. Griffin and W. James, Sir William Dunn School of Pathology, University of Oxford, Oxford 0X1 3RE, UK.
B. Larder, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, UK.
(1) These authors contributed equally to this report.
(2) To whom correspondence should be addressed. E-mail: rodney.phillips{at}ndm.ox.ac.uk


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