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Science 17 November 1995:
Vol. 270. no. 5239, pp. 1189 - 1192
DOI: 10.1126/science.270.5239.1189
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Reports

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Thomas S. Griffith,  Thomas Brunner,  Sharon M. Fletcher,  Douglas R. Green,  Thomas A. Ferguson (1)

The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gld mice, which lack functional FasL, resulted in an inflammation and invasion of ocular tissue without apoptosis. Fas-positive but not Fas-negative tumor cells were killed by apoptosis when placed within isolated anterior segments of the eyes of normal but not FasL-negative mice. FasL messenger RNA and protein were detectable in the eye. Thus, Fas-FasL interactions appear to be an important mechanism for the maintenance of immune privilege.


T. S. Griffith and S. M. Fletcher, Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
T. Brunner and D. R. Green, Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
T. A. Ferguson, Departments of Ophthalmology and Visual Sciences and Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
(1) To whom correspondence should be addressed.


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Invest. Ophthalmol. Vis. Sci. 45, 1169-1173
   Abstract »    Full Text »    PDF »
Fas Signaling Induces Akt Activation and Upregulation of Endothelial Nitric Oxide Synthase Expression.
Y. Takemura, K. Fukuo, O. Yasuda, T. Inoue, N. Inomata, T. Yokoi, H. Kawamoto, T. Suhara, and T. Ogihara (2004)
Hypertension 43, 880-884
   Abstract »    Full Text »    PDF »
Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele.
S. Karray, C. Kress, S. Cuvellier, C. Hue-Beauvais, D. Damotte, C. Babinet, and M. Levi-Strauss (2004)
J. Immunol. 172, 2118-2125
   Abstract »    Full Text »    PDF »
Intraocular Tumor Antigen Drains Specifically to Submandibular Lymph Nodes, Resulting in an Abortive Cytotoxic T Cell Reaction.
Z. F. H. M. Boonman, G. J. D. van Mierlo, M. F. Fransen, K. L. M. C. Franken, R. Offringa, C. J. M. Melief, M. J. Jager, and R. E. M. Toes (2004)
J. Immunol. 172, 1567-1574
   Abstract »    Full Text »    PDF »
Splenic B Cells Act as Antigen Presenting Cells for the Induction of Anterior Chamber-Associated Immune Deviation.
M. E. Skelsey, E. Mayhew, and J. Y. Niederkorn (2003)
Invest. Ophthalmol. Vis. Sci. 44, 5242-5251
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Egr Family Members Regulate Nonlymphoid Expression of Fas Ligand, TRAIL, and Tumor Necrosis Factor during Immune Responses.
N. M. Droin, M. J. Pinkoski, E. Dejardin, and D. R. Green (2003)
Mol. Cell. Biol. 23, 7638-7647
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Structure/Function Analysis of the Murine CD95L Promoter Reveals the Identification of a Novel Transcriptional Repressor and Functional CD28 Response Element.
S. A. Crist, T. S. Griffith, and T. L. Ratliff (2003)
J. Biol. Chem. 278, 35950-35958
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Human Chorionic Gonadotropin Contributes to Maternal Immunotolerance and Endometrial Apoptosis by Regulating Fas-Fas Ligand System.
U. A. Kayisli, B. Selam, O. Guzeloglu-Kayisli, R. Demir, and A. Arici (2003)
J. Immunol. 171, 2305-2313
   Abstract »    Full Text »    PDF »
Retinal transplantation: progress and problems in clinical application.
R. D. Lund, S. J. Ono, D. J. Keegan, and J. M. Lawrence (2003)
J. Leukoc. Biol. 74, 151-160
   Abstract »    Full Text »    PDF »
The immune privilege of corneal grafts.
J. Y. Niederkorn (2003)
J. Leukoc. Biol. 74, 167-171
   Abstract »    Full Text »    PDF »
Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation.
J. W. Streilein (2003)
J. Leukoc. Biol. 74, 179-185
   Abstract »    Full Text »    PDF »
Fas Ligand on Tumor Cells Mediates Inactivation of Neutrophils.
Y.-L. Chen, S.-H. Chen, J.-Y. Wang, and B.-C. Yang (2003)
J. Immunol. 171, 1183-1191
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Regulation of FasL/Fas in Human Trophoblasts: Possible Implications for Chorioamnionitis.
D. R Balkundi, J. A Ziegler, J. F Watchko, C. Craven, and M. Trucco (2003)
Biol Reprod 69, 718-724
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Iris Pigment Epithelium Expressing CD86 (B7-2) Directly Suppresses T Cell Activation In Vitro via Binding to Cytotoxic T Lymphocyte-associated Antigen 4.
S. Sugita and J. W. Streilein (2003)
J. Exp. Med. 198, 161-171
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Characterization of Daunorubicin-Induced Apoptosis in Retinal Pigment Epithelial Cells: Modulation by CD95L.
A. Hueber, M. Weller, G. Welsandt, N. Kociok, B. Kirchhof, and P. Esser (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2851-2857
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Increased Retinal Neovascularization in Fas Ligand-Deficient Mice.
M. H. Davies, J. P. Eubanks, and M. R. Powers (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3202-3210
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Hr44 Secreted with Exosomes: Loss from Ciliary Epithelium in Response to Inflammation.
N. M. McKechnie, D. Copland, and G. Braun (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2650-2656
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Visualization of Cell Death In Vivo during Murine Endotoxin-Induced Uveitis.
P. Yang, J. R. Smith, K. S. Damodar, S. R. Planck, and J. T. Rosenbaum (2003)
Invest. Ophthalmol. Vis. Sci. 44, 1993-1997
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