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Science 20 October 1995:
Vol. 270. no. 5235, pp. 484 - 487
DOI: 10.1126/science.270.5235.484
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Reports

Serial Analysis of Gene Expression

Victor E. Velculescu,  Lin Zhang,  Bert Vogelstein,  Kenneth W. Kinzler (1)

The characteristics of an organism are determined by the genes expressed within it. A method was developed, called serial analysis of gene expression (SAGE), that allows the quantitative and simultaneous analysis of a large number of transcripts. To demonstrate this strategy, short diagnostic sequence tags were isolated from pancreas, concatenated, and cloned. Manual sequencing of 1000 tags revealed a gene expression pattern characteristic of pancreatic function. New pancreatic transcripts corresponding to novel tags were identified. SAGE should provide a broadly applicable means for the quantitative cataloging and comparison of expressed genes in a variety of normal, developmental, and disease states.


V. E. Velculescu and K. W. Kinzler, Oncology Center and the Program in Human Genetics and Molecular Biology, Johns Hopkins University, Baltimore, MD 21231, USA.
L. Zhang and B. Vogelstein, Howard Hughes Medical Institute, Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.
(1) To whom correspondence should be addressed.


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