Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 October 1995:
Vol. 270. no. 5233, pp. 96 - 99
DOI: 10.1126/science.270.5233.96
Prev | Table of Contents | Next

Reports

Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death

C. Michael Knudson,  Kenneth S. K. Tung,  Warren G. Tourtellotte,  Gary A. J. Brown,  Stanley J. Korsmeyer (1)

BAX, a heterodimeric partner of BCL2, counters BCL2 and promotes apoptosis in gain-of-function experiments. A Bax knockout mouse was generated that proved viable but displayed lineage-specific aberrations in cell death. Thymocytes and B cells in this mouse displayed hyperplasia, and Bax-deficient ovaries contained unusual atretic follicles with excess granulosa cells. In contrast, Bax-deficient males were infertile as a result of disordered seminiferous tubules with an accumulation of atypical premeiotic germ cells, but no mature haploid sperm. Multinucleated giant cells and dysplastic cells accompanied massive cell death. Thus, the loss of Bax results in hyperplasia or hypoplasia, depending on the cellular context.


C. M. Knudson, W. G. Tourtellotte, G. A. J. Brown, S. J. Korsmeyer, Howard Hughes Medical Institute and Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA.
K. S. K. Tung, Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
(1) To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ku70 regulates Bax-mediated pathogenesis in laminin-{alpha}2-deficient human muscle cells and mouse models of congenital muscular dystrophy.
V. K. Vishnudas and J. B. Miller (2009)
Hum. Mol. Genet. 18, 4467-4477
   Abstract »    Full Text »    PDF »
Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells.
J. Ramalho-Santos, S. Varum, S. Amaral, P. C. Mota, A. P. Sousa, and A. Amaral (2009)
Hum. Reprod. Update 15, 553-572
   Abstract »    Full Text »    PDF »
Role of dentate gyrus in aligning internal spatial map to external landmark.
J. Won Lee, W. R. Kim, W. Sun, and M. W. Jung (2009)
Learn. Mem. 16, 530-536
   Abstract »    Full Text »    PDF »
The VDAC2-BAK Rheostat Controls Thymocyte Survival.
D. Ren, H. Kim, H.-C. Tu, T. D. Westergard, J. K. Fisher, J. A. Rubens, S. J. Korsmeyer, J. J.-D. Hsieh, and E. H.-Y. Cheng (2009)
Science Signaling 2, ra48
   Abstract »    Full Text »    PDF »
Multiple Genes on Chromosome 7 Regulate Dopaminergic Amacrine Cell Number in the Mouse Retina.
I. E. Whitney, M. A. Raven, D. C. Ciobanu, R. W. Williams, and B. E. Reese (2009)
Invest. Ophthalmol. Vis. Sci. 50, 1996-2003
   Abstract »    Full Text »    PDF »
Steel factor controls primordial germ cell survival and motility from the time of their specification in the allantois, and provides a continuous niche throughout their migration.
Y. Gu, C. Runyan, A. Shoemaker, A. Surani, and C. Wylie (2009)
Development 136, 1295-1303
   Abstract »    Full Text »    PDF »
Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury.
X. Wang, Y. Carlsson, E. Basso, C. Zhu, C. I. Rousset, A. Rasola, B. R. Johansson, K. Blomgren, C. Mallard, P. Bernardi, et al. (2009)
J. Neurosci. 29, 2588-2596
   Abstract »    Full Text »    PDF »
Polyglutamine-Expanded Androgen Receptor Truncation Fragments Activate a Bax-Dependent Apoptotic Cascade Mediated by DP5/Hrk.
J. E. Young, G. A. Garden, R. A. Martinez, F. Tanaka, C. Miguel Sandoval, A. C. Smith, B. L. Sopher, A. Lin, K. H. Fischbeck, L. M. Ellerby, et al. (2009)
J. Neurosci. 29, 1987-1997
   Abstract »    Full Text »    PDF »
Two-step oligoclonal development of male germ cells.
H. Ueno, B. B. Turnbull, and I. L. Weissman (2009)
PNAS 106, 175-180
   Abstract »    Full Text »    PDF »
Dickkopf-Like1 Regulates Postpubertal Spermatocyte Apoptosis and Testosterone Production.
O. Dakhova, D. O'Day, N. Kinet, N. Yucer, M. Wiese, G. Shetty, and P. Ducy (2009)
Endocrinology 150, 404-412
   Abstract »    Full Text »    PDF »
{gamma}-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.
J. L. Lefebvre, Y. Zhang, M. Meister, X. Wang, and J. R. Sanes (2008)
Development 135, 4141-4151
   Abstract »    Full Text »    PDF »
A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-{gamma} gene cluster.
T. Prasad, X. Wang, P. A. Gray, and J. A. Weiner (2008)
Development 135, 4153-4164
   Abstract »    Full Text »    PDF »
The Semaphorin Receptor PlexinA3 Mediates Neuronal Apoptosis during Dorsal Root Ganglia Development.
A. Ben-Zvi, O. Manor, M. Schachner, A. Yaron, M. Tessier-Lavigne, and O. Behar (2008)
J. Neurosci. 28, 12427-12432
   Abstract »    Full Text »    PDF »
Prostaglandin E2 Signals Monocyte/Macrophage Survival to Peroxynitrite via Protein Kinase A Converging in Bad Phosphorylation with the Protein Kinase C{alpha}-Dependent Pathway Driven by 5-Hydroxyeicosatetraenoic Acid.
I. Tommasini, L. Cerioni, L. Palomba, and O. Cantoni (2008)
J. Immunol. 181, 5637-5645
   Abstract »    Full Text »    PDF »
Curcumin suppresses constitutive activation of nuclear factor-{kappa}B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines.
A. R. Hussain, M. Ahmed, N. A. Al-Jomah, A. S. Khan, P. Manogaran, M. Sultana, J. Abubaker, L. C. Platanias, K. S. Al-Kuraya, and S. Uddin (2008)
Mol. Cancer Ther. 7, 3318-3329
   Abstract »    Full Text »    PDF »
Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells.
J. Jin, Q. Hou, T. D. Mullen, Y. H. Zeidan, J. Bielawski, J. M. Kraveka, A. Bielawska, L. M. Obeid, Y. A. Hannun, and Y.-T. Hsu (2008)
J. Biol. Chem. 283, 26509-26517
   Abstract »    Full Text »    PDF »
REVIEW Paper: Pathophysiology of Myocardial Reperfusion Injury: The Role of Genetically Engineered Mouse Models.
A. Ramachandran, S. Jha, and D. J. Lefer (2008)
Vet. Pathol. 45, 698-706
   Abstract »    Full Text »    PDF »
Sexual Differentiation of Vasopressin Innervation of the Brain: Cell Death Versus Phenotypic Differentiation.
G. J. de Vries, M. Jardon, M. Reza, G. J. Rosen, E. Immerman, and N. G. Forger (2008)
Endocrinology 149, 4632-4637
   Abstract »    Full Text »    PDF »
Expression of the proapoptotic protein Bax is reduced in bronchial mucous cells of asthmatic subjects.
K. Schwalm, J. F. Stevens, Z. Jiang, M. R. Schuyler, R. Schrader, S. H. Randell, F. H. Y. Green, and Y. Tesfaigzi (2008)
Am J Physiol Lung Cell Mol Physiol 294, L1102-L1109
   Abstract »    Full Text »    PDF »
Male Germ Cells Require Polyenoic Sphingolipids with Complex Glycosylation for Completion of Meiosis: A LINK TO CERAMIDE SYNTHASE-3.
M. Rabionet, A. C. van der Spoel, C.-C. Chuang, B. von Tumpling-Radosta, M. Litjens, D. Bouwmeester, C. C. Hellbusch, C. Korner, H. Wiegandt, K. Gorgas, et al. (2008)
J. Biol. Chem. 283, 13357-13369
   Abstract »    Full Text »    PDF »
Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor-Induced Apoptosis of Pancreatic {beta}-Cells.
M. D. McKenzie, E. M. Carrington, T. Kaufmann, A. Strasser, D. C.S. Huang, T. W.H. Kay, J. Allison, and H. E. Thomas (2008)
Diabetes 57, 1284-1292
   Abstract »    Full Text »    PDF »
Dynamic regulation of the expression of neurotrophin receptors by Runx3.
S. Nakamura, K. Senzaki, M. Yoshikawa, M. Nishimura, K.-i. Inoue, Y. Ito, S. Ozaki, and T. Shiga (2008)
Development 135, 1703-1711
   Abstract »    Full Text »    PDF »
Pathways involved in testicular germ cell apoptosis in immature rats after FSH suppression.
S. M Ruwanpura, R. I McLachlan, P. G Stanton, K. L Loveland, and S. J Meachem (2008)
J. Endocrinol. 197, 35-43
   Abstract »    Full Text »    PDF »
Follicle-Stimulating Hormone Affects Spermatogonial Survival by Regulating the Intrinsic Apoptotic Pathway in Adult Rats.
S. M. Ruwanpura, R. I. McLachlan, P. G. Stanton, and S. J. Meachem (2008)
Biol Reprod 78, 705-713
   Abstract »    Full Text »    PDF »
Bcl-2-family proteins and hematologic malignancies: history and future prospects.
J. C. Reed (2008)
Blood 111, 3322-3330
   Abstract »    Full Text »    PDF »
Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?.
A-r. Jung, T. W. Kim, I. J. Rhyu, H. Kim, Y. D. Lee, S. Vinsant, R. W. Oppenheim, and W. Sun (2008)
J. Neurosci. 28, 2941-2948
   Abstract »    Full Text »    PDF »
Granulosa Cell Survival and Proliferation Are Altered in Polycystic Ovary Syndrome.
M. Das, O. Djahanbakhch, B. Hacihanefioglu, E. Saridogan, M. Ikram, L. Ghali, M. Raveendran, and A. Storey (2008)
J. Clin. Endocrinol. Metab. 93, 881-887
   Abstract »    Full Text »    PDF »
IL-9 and IL-13 Induce Mucous Cell Metaplasia That Is Reduced by IFN-{gamma} in a Bax-Mediated Pathway.
J. Xiang, J. Rir-Sim-Ah, and Y. Tesfaigzi (2008)
Am. J. Respir. Cell Mol. Biol. 38, 310-317
   Abstract »    Full Text »    PDF »
Nanos2 suppresses meiosis and promotes male germ cell differentiation.
A. Suzuki and Y. Saga (2008)
Genes & Dev. 22, 430-435
   Abstract »    Full Text »    PDF »
The RHOX5 Homeodomain Protein Mediates Transcriptional Repression of the Netrin-1 Receptor Gene Unc5c.
Z. Hu, S. Shanker, J. A. MacLean II, S. L. Ackerman, and M. F. Wilkinson (2008)
J. Biol. Chem. 283, 3866-3876
   Abstract »    Full Text »    PDF »
Gonadotrophins regulate germ cell survival, not proliferation, in normal adult men.
S. M. Ruwanpura, R. I. McLachlan, K. L. Matthiesson, and S. J. Meachem (2008)
Hum. Reprod. 23, 403-411
   Abstract »    Full Text »    PDF »
Both protamine-1 to protamine-2 mRNA ratio and Bcl2 mRNA content in testicular spermatids and ejaculated spermatozoa discriminate between fertile and infertile men.
K. Steger, J. Wilhelm, L. Konrad, T. Stalf, R. Greb, T. Diemer, S. Kliesch, M. Bergmann, and W. Weidner (2008)
Hum. Reprod. 23, 11-16
   Abstract »    Full Text »    PDF »
Diminishing Apoptosis by Deletion of Bax or Overexpression of Bcl-2 Does Not Protect against Infectious Prion Toxicity In Vivo.
A. D. Steele, O. D. King, W. S. Jackson, C. A. Hetz, A. W. Borkowski, P. Thielen, R. Wollmann, and S. Lindquist (2007)
J. Neurosci. 27, 13022-13027
   Abstract »    Full Text »    PDF »
Bcl-XL/Bax Proteins Direct the Fate of Embryonic Cortical Precursor Cells.
M.-Y. Chang, W. Sun, W. Ochiai, K. Nakashima, S.-Y. Kim, C.-H. Park, J. S. Kang, J.-W. Shim, A-Y. Jo, C.-S. Kang, et al. (2007)
Mol. Cell. Biol. 27, 4293-4305
   Abstract »    Full Text »    PDF »
Conditional ablation of GFR{alpha}1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.
T. Uesaka, S. Jain, S. Yonemura, Y. Uchiyama, J. Milbrandt, and H. Enomoto (2007)
Development 134, 2171-2181
   Abstract »    Full Text »    PDF »
Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.
S. Shankar and R. K. Srivastava (2007)
Carcinogenesis 28, 1277-1286
   Abstract »    Full Text »    PDF »
BAX regulates follicular endowment in mice.
C. R Greenfeld, M. E Pepling, J. K Babus, P. A Furth, and J. A Flaws (2007)
Reproduction 133, 865-876
   Abstract »    Full Text »    PDF »
Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
G. I. Perez, A. Jurisicova, L. Wise, T. Lipina, M. Kanisek, A. Bechard, Y. Takai, P. Hunt, J. Roder, M. Grynpas, et al. (2007)
PNAS 104, 5229-5234
   Abstract »    Full Text »    PDF »
Transforming Growth Factor (TGF)-beta1 Stimulates Pulmonary Fibrosis and Inflammation via a Bax-dependent, Bid-activated Pathway That Involves Matrix Metalloproteinase-12.
H.-R. Kang, S. J. Cho, C. G. Lee, R. J. Homer, and J. A. Elias (2007)
J. Biol. Chem. 282, 7723-7732
   Abstract »    Full Text »    PDF »
Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis.
J. J. Shacka, B. J. Klocke, C. Young, M. Shibata, J. W. Olney, Y. Uchiyama, P. Saftig, and K. A. Roth (2007)
J. Neurosci. 27, 2081-2090
   Abstract »    Full Text »    PDF »
Switch from BAX-dependent to BAX-independent germ cell loss during the development of fetal mouse ovaries.
M. Alton and T. Taketo (2007)
J. Cell Sci. 120, 417-424
   Abstract »    Full Text »    PDF »
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2.
S. M. C. Przemeck, C. A. Duckworth, and D. M. Pritchard (2007)
Am J Physiol Gastrointest Liver Physiol 292, G620-G627
   Abstract »    Full Text »    PDF »
BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries.
C. R Greenfeld, J. K Babus, P. A Furth, S. Marion, P. B Hoyer, and J. A Flaws (2007)
Reproduction 133, 107-116
   Abstract »    Full Text »    PDF »
Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax.
X. Liang, Y. Liu, Q. Zhang, L. Gao, L. Han, C. Ma, L. Zhang, Y. H. Chen, and W. Sun (2007)
J. Immunol. 178, 503-510
   Abstract »    Full Text »    PDF »
Apoptosis and Molecular Pathways in the Seminiferous Epithelium of Aged and Photoinhibited Syrian Hamsters (Mesocricetus auratus).
E. Morales, C. Ferrer, A. Zuasti, J. C. Garcia-Borron, M. Canteras, and L. M. Pastor (2007)
J Androl 28, 123-135
   Abstract »    Full Text »    PDF »
Neuromuscular Development in the Absence of Programmed Cell Death: Phenotypic Alteration of Motoneurons and Muscle.
R. R. Buss, T. W. Gould, J. Ma, S. Vinsant, D. Prevette, A. Winseck, K. A. Toops, J. A. Hammarback, T. L. Smith, and R. W. Oppenheim (2006)
J. Neurosci. 26, 13413-13427
   Abstract »    Full Text »    PDF »
p21 delays tumor onset by preservation of chromosomal stability.
J. A. Barboza, G. Liu, Z. Ju, A. K. El-Naggar, and G. Lozano (2006)
PNAS 103, 19842-19847
   Abstract »    Full Text »    PDF »
Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration.
C. Runyan, K. Schaible, K. Molyneaux, Z. Wang, L. Levin, and C. Wylie (2006)
Development 133, 4861-4869
   Abstract »    Full Text »    PDF »
NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death.
J. C. de Rivero Vaccari, G. P. Casey, S. Aleem, W.-M. Park, and R. A. Corriveau (2006)
PNAS 103, 16971-16976
   Abstract »    Full Text »    PDF »
Carcinogenesis and apoptosis: paradigms and paradoxes.
B. Zhivotovsky and S. Orrenius (2006)
Carcinogenesis 27, 1939-1945
   Abstract »    Full Text »    PDF »
Ovarian follicle development and transgenic mouse models.
K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws (2006)
Hum. Reprod. Update 12, 537-555
   Abstract »    Full Text »    PDF »
Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS..
T. W. Gould, R. R. Buss, S. Vinsant, D. Prevette, W. Sun, C. M. Knudson, C. E. Milligan, and R. W. Oppenheim (2006)
J. Neurosci. 26, 8774-8786
   Abstract »    Full Text »    PDF »
Naturally suppressed apoptosis prevents follicular atresia and oocyte reserve decline in the adult ovary of Lagostomus maximus (Rodentia, Caviomorpha)..
F. Jensen, M. A Willis, M. S Albamonte, M. B Espinosa, and A. D Vitullo (2006)
Reproduction 132, 301-308
   Abstract »    Full Text »    PDF »
Caspase 2 Activity Contributes to the Initial Wave of Germ Cell Apoptosis During the First Round of Spermatogenesis.
S. Zheng, T. T. Turner, and J. J. Lysiak (2006)
Biol Reprod 74, 1026-1033
   Abstract »    Full Text »    PDF »
Bax does not have to adopt its final form to drive T cell death.
Y. Zhu, X. Liu, D. Hildeman, F. W. Peyerl, J. White, E. Kushnir, J. Kappler, and P. Marrack (2006)
J. Exp. Med. 203, 1147-1152
   Abstract »    Full Text »    PDF »
Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis..
L. van der Weyden, M. J. Arends, O. E. Chausiaux, P. J. Ellis, U. C. Lange, M. A. Surani, N. Affara, Y. Murakami, D. J. Adams, and A. Bradley (2006)
Mol. Cell. Biol. 26, 3595-3609
   Abstract »    Full Text »    PDF »
Specific Requirement for Bax, Not Bak, in Myc-induced Apoptosis and Tumor Suppression in Vivo.
T. B. Dansen, J. Whitfield, F. Rostker, L. Brown-Swigart, and G. I. Evan (2006)
J. Biol. Chem. 281, 10890-10895
   Abstract »    Full Text »    PDF »
Bafilomycin A1 Inhibits Chloroquine-Induced Death of Cerebellar Granule Neurons.
J. J. Shacka, B. J. Klocke, M. Shibata, Y. Uchiyama, G. Datta, R. E. Schmidt, and K. A. Roth (2006)
Mol. Pharmacol. 69, 1125-1136
   Abstract »    Full Text »    PDF »
Study of two markers of apoptosis and meiotic segregation in ejaculated sperm of chromosomal translocation carrier patients.
F. Brugnon, E. Van Assche, G. Verheyen, B. Sion, D. Boucher, J.L. Pouly, L. Janny, P. Devroey, I. Liebaers, and A. Van Steirteghem (2006)
Hum. Reprod. 21, 685-693
   Abstract »    Full Text »    PDF »
Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
D.-S. Pei, X.-T. Wang, Y. Liu, Y.-F. Sun, Q.-H. Guan, W. Wang, J.-Z. Yan, Y.-Y. Zong, T.-L. Xu, and G.-Y. Zhang (2006)
Brain 129, 465-479
   Abstract »    Full Text »    PDF »
Changes in Cytosolic Ca2+ Levels Regulate Bcl-xS and Bcl-xL Expression in Spermatogenic Cells during Apoptotic Death.
D. P. Mishra, R. Pal, and C. Shaha (2006)
J. Biol. Chem. 281, 2133-2143
   Abstract »    Full Text »    PDF »
Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary.
R G Lea, L P Andrade, M T Rae, L T Hannah, C E Kyle, J F Murray, S M Rhind, and D W Miller (2006)
Reproduction 131, 113-124
   Abstract »    Full Text »    PDF »
Methoxychlor Directly Affects Ovarian Antral Follicle Growth and Atresia through Bcl-2- and Bax-Mediated Pathways.
K. P. Miller, R. K. Gupta, C. R. Greenfeld, J. K. Babus, and J. A. Flaws (2005)
Toxicol. Sci. 88, 213-221
   Abstract »    Full Text »    PDF »
Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death.
M. J. O'Hare, N. Kushwaha, Y. Zhang, H. Aleyasin, S. M. Callaghan, R. S. Slack, P. R. Albert, I. Vincent, and D. S. Park (2005)
J. Neurosci. 25, 8954-8966
   Abstract »    Full Text »    PDF »
Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
O. Takeuchi, J. Fisher, H. Suh, H. Harada, B. A. Malynn, and S. J. Korsmeyer (2005)
PNAS 102, 11272-11277
   Abstract »    Full Text »    PDF »
Bax translocates from cytosol to mitochondria in cardiac cells during apoptosis: development of a GFP-Bax-stable H9c2 cell line for apoptosis analysis.
Q. Hou and Y.-T. Hsu (2005)
Am J Physiol Heart Circ Physiol 289, H477-H487
   Abstract »    Full Text »    PDF »
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.
J. Hutcheson, J. C. Scatizzi, E. Bickel, N. J. Brown, P. Bouillet, A. Strasser, and H. Perlman (2005)
J. Exp. Med. 201, 1949-1960
   Abstract »    Full Text »    PDF »
Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulation of Pancreatic {beta}-Cell Survival Is Dependent upon Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (PKB) Signaling, Inactivation of the Forkhead Transcription Factor Foxo1, and Down-regulation of bax Expression.
S.-J. Kim, K. Winter, C. Nian, M. Tsuneoka, Y. Koda, and C. H. S. McIntosh (2005)
J. Biol. Chem. 280, 22297-22307
   Abstract »    Full Text »    PDF »
Phosphorylation of c-Jun in Avian and Mammalian Motoneurons In Vivo during Programmed Cell Death: An Early Reversible Event in the Apoptotic Cascade.
W. Sun, T. W. Gould, J. Newbern, C. Milligan, S. Y. Choi, H. Kim, and R. W. Oppenheim (2005)
J. Neurosci. 25, 5595-5603
   Abstract »    Full Text »    PDF »
Effects of Bax Gene Deletion on Muscle and Motoneuron Degeneration in a Sexually Dimorphic Neuromuscular System.
D. A. Jacob, C. L. Bengston, and N. G. Forger (2005)
J. Neurosci. 25, 5638-5644
   Abstract »    Full Text »    PDF »
Persistent Fetal Ocular Vasculature in Mice Deficient in Bax and Bak.
P. Hahn, T. Lindsten, M. Tolentino, C. B. Thompson, J. Bennett, and J. L. Dunaief (2005)
Arch Ophthalmol 123, 797-802
   Abstract »    Full Text »    PDF »
Muscle-specific BCL2 expression ameliorates muscle disease in laminin {alpha}2-deficient, but not in dystrophin-deficient, mice.
J. A. Dominov, A. J. Kravetz, M. Ardelt, C. A. Kostek, M. L. Beermann, and J. B. Miller (2005)
Hum. Mol. Genet. 14, 1029-1040
   Abstract »    Full Text »    PDF »
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.
D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look (2005)
Blood 105, 3278-3285
   Abstract »    Full Text »    PDF »
Neurons Exclusively Express N-Bak, a BH3 Domain-only Bak Isoform That Promotes Neuronal Apoptosis.
T. Uo, Y. Kinoshita, and R. S. Morrison (2005)
J. Biol. Chem. 280, 9065-9073
   Abstract »    Full Text »    PDF »
Common Polymorphism G(-248)A in the Promoter Region of the bax Gene Results in Significantly Shorter Survival in Patients With Chronic Lymphocytic Leukemia Once Treatment Is Initiated.
J. Starczynski, C. Pepper, G. Pratt, L. Hooper, A. Thomas, D. Milligan, P. Bentley, and C. Fegan (2005)
J. Clin. Oncol. 23, 1514-1521
   Abstract »    Full Text »    PDF »
Bcl-XL specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum.
M. Klee and F. X. Pimentel-Muinos (2005)
J. Cell Biol. 168, 723-734
   Abstract »    Full Text »    PDF »
Defining the Role of the Bcl-2 Family of Proteins in the Nervous System.
T. Lindsten, W.-X. Zong, and C. B. Thompson (2005)
Neuroscientist 11, 10-15
   Abstract »    PDF »
Pea3 Transcription Factor Cooperates with USF-1 in Regulation of the Murine bax Transcription without Binding to an Ets-binding Site.
V. Firlej, B. Bocquet, X. Desbiens, Y. de Launoit, and A. Chotteau-Lelievre (2005)
J. Biol. Chem. 280, 887-898
   Abstract »    Full Text »    PDF »
Inaugural Article: Gamma protocadherins are required for synaptic development in the spinal cord.
J. A. Weiner, X. Wang, J. C. Tapia, and J. R. Sanes (2005)
PNAS 102, 8-14
   Abstract »    Full Text »    PDF »
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.
R. Chiesa, P. Piccardo, S. Dossena, L. Nowoslawski, K. A. Roth, B. Ghetti, and D. A. Harris (2005)
PNAS 102, 238-243
   Abstract »    Full Text »    PDF »
Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.
J. Liu, D. P. Thewke, Y. R. Su, M. F. Linton, S. Fazio, and M. S. Sinensky (2005)
Arterioscler Thromb Vasc Biol 25, 174-179
   Abstract »    Full Text »    PDF »
Effects of Acid Sphingomyelinase Deficiency on Male Germ Cell Development and Programmed Cell Death.
M. Otala, M. O. Pentikainen, T. Matikainen, L. Suomalainen, J. K. Hakala, G. I. Perez, M. Tenhunen, K. Erkkila, P. Kovanen, M. Parvinen, et al. (2005)
Biol Reprod 72, 86-96
   Abstract »    Full Text »    PDF »
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax.
W. Sun, A. Winseck, S. Vinsant, O.-h. Park, H. Kim, and R. W. Oppenheim (2004)
J. Neurosci. 24, 11205-11213
   Abstract »    Full Text »    PDF »
The mitochondrial-dependent pathway is chronically affected in testicular germ cell death in adult rats exposed in utero to anti-androgens.
A Bozec, F Chuzel, S Chater, C Paulin, R Bars, M Benahmed, and C Mauduit (2004)
J. Endocrinol. 183, 79-90
   Abstract »    Full Text »    PDF »
Deletion of Bax eliminates sex differences in the mouse forebrain.
N. G. Forger, G. J. Rosen, E. M. Waters, D. Jacob, R. B. Simerly, and G. J. de Vries (2004)
PNAS 101, 13666-13671
   Abstract »    Full Text »    PDF »
In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation.
S. Erster, M. Mihara, R. H. Kim, O. Petrenko, and U. M. Moll (2004)
Mol. Cell. Biol. 24, 6728-6741
   Abstract »    Full Text »    PDF »
Interleukin-7 Inactivates the Pro-apoptotic Protein Bad Promoting T Cell Survival.
W. Q. Li, Q. Jiang, A. R. Khaled, J. R. Keller, and S. K. Durum (2004)
J. Biol. Chem. 279, 29160-29166
   Abstract »    Full Text »    PDF »
On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis.
W. Y. Almawi, O. K. Melemedjian, and M. M. A. Jaoude (2004)
J. Leukoc. Biol. 76, 7-14
   Abstract »    Full Text »    PDF »
The Murine Testicular Transcriptome: Characterizing Gene Expression in the Testis During the Progression of Spermatogenesis.
J. E. Shima, D. J. McLean, J. R. McCarrey, and M. D. Griswold (2004)
Biol Reprod 71, 319-330
   Abstract »    Full Text »    PDF »
Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice.
T. Nakamoto, A. Shiratsuchi, H. Oda, K. Inoue, T. Matsumura, M. Ichikawa, T. Saito, S. Seo, K. Maki, T. Asai, et al. (2004)
Genes Cells 9, 575-589
   Abstract »    Full Text »    PDF »
Methoxychlor-Induced Atresia in the Mouse Involves Bcl-2 Family Members, but Not Gonadotropins or Estradiol.
C. Borgeest, K. P. Miller, R. Gupta, C. Greenfeld, K. S. Hruska, P. Hoyer, and J. A. Flaws (2004)
Biol Reprod 70, 1828-1835
   Abstract »    Full Text »    PDF »
An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria.
D. Poncet, N. Larochette, A.-L. Pauleau, P. Boya, A.-A. Jalil, P.-F. Cartron, F. Vallette, C. Schnebelen, L. M. Bartle, A. Skaletskaya, et al. (2004)
J. Biol. Chem. 279, 22605-22614
   Abstract »    Full Text »    PDF »
xPhosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils.
S. J. Gardai, D. A. Hildeman, S. K. Frankel, B. B. Whitlock, S. C. Frasch, N. Borregaard, P. Marrack, D. L. Bratton, and P. M. Henson (2004)
J. Biol. Chem. 279, 21085-21095
   Abstract »    Full Text »    PDF »
Apoptotic Signaling Pathways Induced by Nitric Oxide in Human Lymphoblastoid Cells Expressing Wild-Type or Mutant p53.
C.-Q. Li, A. I. Robles, C. L. Hanigan, L. J. Hofseth, L. J. Trudel, C. C. Harris, and G. N. Wogan (2004)
Cancer Res. 64, 3022-3029
   Abstract »    Full Text »    PDF »
Mutations in a Novel Locus on Mouse Chromosome 11 Resulting in Male Infertility Associated with Defects in Microtubule Assembly and Sperm Tail Function.
A. T. Clark, K. Firozi, and M. J. Justice (2004)
Biol Reprod 70, 1317-1324
   Abstract »    Full Text »    PDF »
Cyclin A1 protein shows haplo-insufficiency for normal fertility in male mice.
T. van der Meer, W-Y I. Chan, L. S Palazon, C. Nieduszynski, M. Murphy, J. Sobczak-Thepot, M. Carrington, and W. H Colledge (2004)
Reproduction 127, 503-511
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)