Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 September 1995:
Vol. 269. no. 5232, pp. 1885 - 1888
DOI: 10.1126/science.7569933
Prev | Table of Contents | Next

Articles

Science, Vol 269, Issue 5232, 1885-1888
Copyright © 1995 by American Association for the Advancement of Science

articles

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35

NJ Bump, M Hackett, M Hugunin, S Seshagiri, K Brady, P Chen, C Ferenz, S Franklin, T Ghayur, P Li, and al. et

BASF Bioresearch Corporation, Worcester, MA 01605, USA.

The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from its precursor form and blocked ICE-induced apoptosis. Inhibition of enzymatic activity correlated with the cleavage of p35 and the formation of a stable ICE-p35 complex. The ability of p35 to block apoptosis in different pathways and in distantly related organisms suggests a central and conserved role for ICE-like proteases in the induction of apoptosis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Alix and ALG-2 Are Involved in Tumor Necrosis Factor Receptor 1-induced Cell Death.
A.-L. Mahul-Mellier, F. Strappazzon, A. Petiot, C. Chatellard-Causse, S. Torch, B. Blot, K. Freeman, L. Kuhn, J. Garin, J.-M. Verna, et al. (2008)
J. Biol. Chem. 283, 34954-34965
   Abstract »    Full Text »    PDF »
Functional analysis of the putative antiapoptotic genes, p49 and iap4, of Spodoptera litura nucleopolyhedrovirus with RNAi.
Q. Yu, T. Lin, G. Feng, K. Yang, and Y. Pang (2008)
J. Gen. Virol. 89, 1873-1880
   Abstract »    Full Text »    PDF »
Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors.
M. P. Guy and P. D. Friesen (2008)
J. Virol. 82, 7504-7514
   Abstract »    Full Text »    PDF »
Termination of damaged protein repair defines the occurrence of symptoms in carriers of the m.3243A>G tRNALeu mutation.
R G E van Eijsden, L M T Eijssen, P J Lindsey, C M M van den Burg, L E A de Wit, M E Rubio-Gozalbo, C E M de Die, T Ayoubi, W Sluiter, I F M de Coo, et al. (2008)
J. Med. Genet. 45, 525-534
   Abstract »    Full Text »    PDF »
Caspase Cleavage of HER-2 Releases a Bad-like Cell Death Effector.
A. M. Strohecker, F. Yehiely, F. Chen, and V. L. Cryns (2008)
J. Biol. Chem. 283, 18269-18282
   Abstract »    Full Text »    PDF »
Baculovirus Caspase Inhibitors P49 and P35 Block Virus-Induced Apoptosis Downstream of Effector Caspase DrICE Activation in Drosophila melanogaster Cells.
E. Lannan, R. Vandergaast, and P. D. Friesen (2007)
J. Virol. 81, 9319-9330
   Abstract »    Full Text »    PDF »
Genome of the most widely used viral biopesticide: Anticarsia gemmatalis multiple nucleopolyhedrovirus..
J. V. d. C. Oliveira, J. L. C. Wolff, A. Garcia-Maruniak, B. M. Ribeiro, M. E. B. de Castro, M. L. de Souza, F. Moscardi, J. E. Maruniak, and P. M. d. A. Zanotto (2006)
J. Gen. Virol. 87, 3233-3250
   Abstract »    Full Text »    PDF »
Identification of Proteins Cleaved Downstream of Caspase Activation in Monocytes Undergoing Macrophage Differentiation.
S. Cathelin, C. Rebe, L. Haddaoui, N. Simioni, F. Verdier, M. Fontenay, S. Launay, P. Mayeux, and E. Solary (2006)
J. Biol. Chem. 281, 17779-17788
   Abstract »    Full Text »    PDF »
Chlamydia Inhibit Host Cell Apoptosis by Degradation of Proapoptotic BH3-only Proteins.
S. F. Fischer, J. Vier, S. Kirschnek, A. Klos, S. Hess, S. Ying, and G. Hacker (2004)
J. Exp. Med. 200, 905-916
   Abstract »    Full Text »    PDF »
Crystal Structure of an Invertebrate Caspase.
C. M. Forsyth, D. Lemongello, D. J. LaCount, P. D. Friesen, and A. J. Fisher (2004)
J. Biol. Chem. 279, 7001-7008
   Abstract »    Full Text »    PDF »
Ultraviolet-C Overexposure Induces Programmed Cell Death in Arabidopsis, Which Is Mediated by Caspase-like Activities and Which Can Be Suppressed by Caspase Inhibitors, p35 and Defender against Apoptotic Death.
A. Danon, V. I. Rotari, A. Gordon, N. Mailhac, and P. Gallois (2004)
J. Biol. Chem. 279, 779-787
   Abstract »    Full Text »    PDF »
Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac.
Y. Huang, R. L. Rich, D. G. Myszka, and H. Wu (2003)
J. Biol. Chem. 278, 49517-49522
   Abstract »    Full Text »    PDF »
Activation of Caspases Is Required for Osteoblastic Differentiation.
M. Mogi and A. Togari (2003)
J. Biol. Chem. 278, 47477-47482
   Abstract »    Full Text »    PDF »
Baculovirus P35 interacts with a subunit of human RNA polymerase II and can enhance promoter activity in human cells.
D. Takramah, B. M. Seiffert, S. Schaller, M. Vigneron, and G. Hacker (2003)
J. Gen. Virol. 84, 3011-3019
   Abstract »    Full Text »    PDF »
Ribavirin and Alpha Interferon Enhance Death Receptor-Mediated Apoptosis and Caspase Activation in Human Hepatoma Cells.
S. F. Schlosser, M. Schuler, C. P. Berg, K. Lauber, K. Schulze-Osthoff, F. W. Schmahl, and S. Wesselborg (2003)
Antimicrob. Agents Chemother. 47, 1912-1921
   Abstract »    Full Text »    PDF »
Cell Death in the Unicellular Chlorophyte Dunaliella tertiolecta. A Hypothesis on the Evolution of Apoptosis in Higher Plants and Metazoans.
M. Segovia, L. Haramaty, J. A. Berges, and P. G. Falkowski (2003)
Plant Physiology 132, 99-105
   Abstract »    Full Text »    PDF »
Silencing of the Baculovirus Op-iap3 Gene by RNA Interference Reveals that It Is Required for Prevention of Apoptosis during Orgyia pseudotsugata M Nucleopolyhedrovirus Infection of Ld652Y Cells.
J. C. Means, I. Muro, and R. J. Clem (2003)
J. Virol. 77, 4481-4488
   Abstract »    Full Text »    PDF »
Promyelocytic Leukemia Protein Sensitizes Tumor Necrosis Factor alpha -Induced Apoptosis by Inhibiting the NF-kappa B Survival Pathway.
W.-S. Wu, Z.-X. Xu, W. N. Hittelman, P. Salomoni, P. P. Pandolfi, and K.-S. Chang (2003)
J. Biol. Chem. 278, 12294-12304
   Abstract »    Full Text »    PDF »
Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential.
J. H. Von der Thusen, J. Kuiper, T. J. C. Van Berkel, and E. A. L. Biessen (2003)
Pharmacol. Rev. 55, 133-166
   Abstract »    Full Text »    PDF »
Mutational Analyses of the p35-Caspase Interaction. A BOWSTRING KINETIC MODEL OF CASPASE INHIBITION BY p35.
G. Xu, R. L. Rich, C. Steegborn, T. Min, Y. Huang, D. G. Myszka, and H. Wu (2003)
J. Biol. Chem. 278, 5455-5461
   Abstract »    Full Text »    PDF »
In Vivo Induction of Apoptosis Correlating with Reduced Infectivity during Baculovirus Infection.
T. E. Clarke and R. J. Clem (2003)
J. Virol. 77, 2227-2232
   Abstract »    Full Text »    PDF »
Specific involvement of caspases in the differentiation of monocytes into macrophages.
O. Sordet, C. Rebe, S. Plenchette, Y. Zermati, O. Hermine, W. Vainchenker, C. Garrido, E. Solary, and L. Dubrez-Daloz (2002)
Blood 100, 4446-4453
   Abstract »    Full Text »    PDF »
Characterization of the Apoptosis Suppressor Protein P49 from the Spodoptera littoralis Nucleopolyhedrovirus.
Z. Pei, G. Reske, Q. Huang, B. D. Hammock, Y. Qi, and N. Chejanovsky (2002)
J. Biol. Chem. 277, 48677-48684
   Abstract »    Full Text »    PDF »
Expression of the antiapoptotic baculovirus p35 gene in tomato blocks programmed cell death and provides broad-spectrum resistance to disease.
J. E. Lincoln, C. Richael, B. Overduin, K. Smith, R. Bostock, and D. G. Gilchrist (2002)
PNAS 99, 15217-15221
   Abstract »    Full Text »    PDF »
Sensitivity of Photoreceptor-Derived Cell Line (661W) to Baculoviral p35, Z-VAD.FMK, and Fas-Associated Death Domain.
G. Tuohy, S. Millington-Ward, P. F. Kenna, P. Humphries, and G. J. Farrar (2002)
Invest. Ophthalmol. Vis. Sci. 43, 3583-3589
   Abstract »    Full Text »    PDF »
Adenovirus-mediated expression of p35 prevents hypoxia/reoxygenation injury by reducing reactive oxygen species and caspase activity.
T. Date, A. J Belanger, S. Mochizuki, J. A Sullivan, L. X Liu, A. Scaria, S. H Cheng, R. J Gregory, and C. Jiang (2002)
Cardiovasc Res 55, 309-319
   Abstract »    Full Text »    PDF »
Activation of Caspase Pathways during Iron Chelator-mediated Apoptosis.
B. T. Greene, J. Thorburn, M. C. Willingham, A. Thorburn, R. P. Planalp, M. W. Brechbiel, J. Jennings-Gee, J. Wilkinson IV, F. M. Torti, and S. V. Torti (2002)
J. Biol. Chem. 277, 25568-25575
   Abstract »    Full Text »    PDF »
Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis.
F. Chen, M. Kamradt, M. Mulcahy, Y. Byun, H. Xu, M. J. McKay, and V. L. Cryns (2002)
J. Biol. Chem. 277, 16775-16781
   Abstract »    Full Text »    PDF »
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.
B. M. Hersh, E. Hartwieg, and H. R. Horvitz (2002)
PNAS 99, 4355-4360
   Abstract »    Full Text »    PDF »
A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye.
S.-Y. Yu, S. J. Yoo, L. Yang, C. Zapata, A. Srinivasan, B. A. Hay, and N. E. Baker (2002)
Development 129, 3269-3278
   Abstract »    Full Text »    PDF »
Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease.
V. Viswanath, Y. Wu, R. Boonplueang, S. Chen, F. F. Stevenson, F. Yantiri, L. Yang, M. F. Beal, and J. K. Andersen (2001)
J. Neurosci. 21, 9519-9528
   Abstract »    Full Text »    PDF »
Vaccinia Virus Infection Disarms the Mitochondrion-Mediated Pathway of the Apoptotic Cascade by Modulating the Permeability Transition Pore.
S. T. Wasilenko, A. F. A. Meyers, K. Vander Helm, and M. Barry (2001)
J. Virol. 75, 11437-11448
   Abstract »    Full Text »
Poliovirus Protein 3A Inhibits Tumor Necrosis Factor (TNF)-Induced Apoptosis by Eliminating the TNF Receptor from the Cell Surface.
N. Neznanov, A. Kondratova, K. M. Chumakov, B. Angres, B. Zhumabayeva, V. I. Agol, and A. V. Gudkov (2001)
J. Virol. 75, 10409-10420
   Abstract »    Full Text »    PDF »
xIAP Induces Cell-Cycle Arrest and Activates Nuclear Factor-{{kappa}}B : New Survival Pathways Disabled by Caspase-Mediated Cleavage During Apoptosis of Human Endothelial Cells.
B. Levkau, K. J. Garton, N. Ferri, K. Kloke, J.-R. Nofer, H. A. Baba, E. W. Raines, and G. Breithardt (2001)
Circ. Res. 88, 282-290
   Abstract »    Full Text »    PDF »
Proteases for Cell Suicide: Functions and Regulation of Caspases.
H. Y. Chang and X. Yang (2000)
Microbiol. Mol. Biol. Rev. 64, 821-846
   Abstract »    Full Text »    PDF »
Chemotherapy Triggers Apoptosis in a Caspase-8-dependent and Mitochondria-controlled Manner in the Non-Small Cell Lung Cancer Cell Line NCI-H460.
C. G. Ferreira, S. W. Span, G. J. Peters, F. A. E. Kruyt, and G. Giaccone (2000)
Cancer Res. 60, 7133-7141
   Abstract »    Full Text »
The inhibitors of apoptosis of Epiphyas postvittana nucleopolyhedrovirus.
T. Maguire, P. Harrison, O. Hyink, J. Kalmakoff, and V. K. Ward (2000)
J. Gen. Virol. 81, 2803-2811
   Abstract »    Full Text »
Keloid-Derived Fibroblasts Are Refractory to Fas-Mediated Apoptosis and Neutralization of Autocrine Transforming Growth Factor-{beta}1 Can Abrogate this Resistance.
T. Chodon, T. Sugihara, H. H. Igawa, E. Funayama, and H. Furukawa (2000)
Am. J. Pathol. 157, 1661-1669
   Abstract »    Full Text »    PDF »
Identification of Potassium-Dependent and -Independent Components of the Apoptotic Machinery in Mouse Ovarian Germ Cells and Granulosa Cells.
G. I. Perez, D. V. Maravei, A. M. Trbovich, J. A. Cidlowski, J. L. Tilly, and F. M. Hughes Jr (2000)
Biol Reprod 63, 1358-1369
   Abstract »    Full Text »
The Chicken Anemia Virus-Derived Protein Apoptin Requires Activation of Caspases for Induction of Apoptosis in Human Tumor Cells.
A. A. A. M. Danen-van Oorschot, A. J. van der Eb, and M. H. M. Noteborn (2000)
J. Virol. 74, 7072-7078
   Abstract »    Full Text »
The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells.
G. Tezel and M. B. Wax (2000)
J. Neurosci. 20, 3552-3562
   Abstract »    Full Text »    PDF »
The Prodomain of Caspase-1 Enhances Fas-mediated Apoptosis through Facilitation of Caspase-8 Activation.
T. Tatsuta, A. Shiraishi, and J. D. Mountz (2000)
J. Biol. Chem. 275, 14248-14254
   Abstract »    Full Text »    PDF »
TAK1 Participates in c-Jun N-Terminal Kinase Signaling during Drosophila Development.
Y. Takatsu, M. Nakamura, M. Stapleton, M. C. Danos, K. Matsumoto, M. B. O'Connor, H. Shibuya, and N. Ueno (2000)
Mol. Cell. Biol. 20, 3015-3026
   Abstract »    Full Text »
The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1{beta}-Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells.
J. L. Young, G. K. Sukhova, D. Foster, W. Kisiel, P. Libby, and U. Schonbeck (2000)
J. Exp. Med. 191, 1535-1544
   Abstract »    Full Text »    PDF »
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis.
C. Heylbroeck, S. Balachandran, M. J. Servant, C. DeLuca, G. N. Barber, R. Lin, and J. Hiscott (2000)
J. Virol. 74, 3781-3792
   Abstract »    Full Text »
Biochemical and Genetic Interactions between Drosophila Caspases and the Proapoptotic Genes rpr, hid, and grim.
Z. Song, B. Guan, A. Bergman, D. W. Nicholson, N. A. Thornberry, E. P. Peterson, and H. Steller (2000)
Mol. Cell. Biol. 20, 2907-2914
   Abstract »    Full Text »
Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development.
P. Doerfler, K. A. Forbush, and R. M. Perlmutter (2000)
J. Immunol. 164, 4071-4079
   Abstract »    Full Text »    PDF »
Inhibitor of Apoptosis Protein hILP Undergoes Caspase-mediated Cleavage during T Lymphocyte Apoptosis.
D. E. Johnson, B. R. Gastman, E. Wieckowski, G.-Q. Wang, A. Amoscato, S. M. Delach, and H. Rabinowich (2000)
Cancer Res. 60, 1818-1823
   Abstract »    Full Text »
Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9.
Q. Huang, Q. L. Deveraux, S. Maeda, G. S. Salvesen, H. R. Stennicke, B. D. Hammock, and J. C. Reed (2000)
PNAS 97, 1427-1432
   Abstract »    Full Text »    PDF »
Ribozyme-Mediated Inhibition of Caspase-3 Protects Cerebellar Granule Cells from Apoptosis Induced by Serum-Potassium Deprivation.
B. A. Eldadah, R. F. Ren, and A. I. Faden (2000)
J. Neurosci. 20, 179-186
   Abstract »    Full Text »    PDF »
Baculovirus-based Genetic Screen for Antiapoptotic Genes Identifies a Novel IAP.
S. Seshagiri, D. Vucic, J. Lee, and V. M. Dixit (1999)
J. Biol. Chem. 274, 36769-36773
   Abstract »    Full Text »    PDF »
SPI-1-Dependent Host Range of Rabbitpox Virus and Complex Formation with Cathepsin G Is Associated with Serpin Motifs.
K. B. Moon, P. C. Turner, and R. W. Moyer (1999)
J. Virol. 73, 8999-9010
   Abstract »    Full Text »    PDF »
The Levels of the bancal Product, a Drosophila Homologue of Vertebrate hnRNP K Protein, Affect Cell Proliferation and Apoptosis in Imaginal Disc Cells.
B. Charroux, C. Angelats, L. Fasano, S. Kerridge, and C. Vola (1999)
Mol. Cell. Biol. 19, 7846-7856
   Abstract »    Full Text »    PDF »
Inhibition of Caspase Activity in Retinal Cell Apoptosis Induced by Various Stimuli In Vitro.
G. Tezel and M. B. Wax (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2660-2667
   Abstract »    Full Text »    PDF »
Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status: Implications for Initiation of Autoimmunity.
L. Casciola-Rosen, F. Andrade, D. Ulanet, W. B. Wong, and A. Rosen (1999)
J. Exp. Med. 190, 815-826
   Abstract »    Full Text »    PDF »
Caspase Inhibition by Baculovirus P35 Requires Interaction between the Reactive Site Loop and the beta -Sheet Core.
S. J. Zoog, J. Bertin, and P. D. Friesen (1999)
J. Biol. Chem. 274, 25995-26002
   Abstract »    Full Text »    PDF »
Myxoma Virus Serp2 Is a Weak Inhibitor of Granzyme B and Interleukin-1beta -Converting Enzyme In Vitro and Unlike CrmA Cannot Block Apoptosis in Cowpox Virus-Infected Cells.
P. C. Turner, M. C. Sancho, S. R. Thoennes, A. Caputo, R. C. Bleackley, and R. W. Moyer (1999)
J. Virol. 73, 6394-6404
   Abstract »    Full Text »
The Baculovirus PE38 Protein Augments Apoptosis Induced by Transactivator IE1.
E. A. Prikhod'ko and L. K. Miller (1999)
J. Virol. 73, 6691-6699
   Abstract »    Full Text »
Expression Level of Bcl-2 Determines Anti- or Proapoptotic Function.
N. Shinoura, Y. Yoshida, M. Nishimura, Y. Muramatsu, A. Asai, T. Kirino, and H. Hamada (1999)
Cancer Res. 59, 4119-4128
   Abstract »    Full Text »    PDF »
Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases.
B. B. Wolf and D. R. Green (1999)
J. Biol. Chem. 274, 20049-20052
   Full Text »    PDF »
Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy.
J. Narula, P. Pandey, E. Arbustini, N. Haider, N. Narula, F. D. Kolodgie, B. Dal Bello, M. J. Semigran, A. Bielsa-Masdeu, G. W. Dec, et al. (1999)
PNAS 96, 8144-8149
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-{alpha}-Activated Cell Death Pathways in NIT-1 Insulinoma Cells and Primary Pancreatic {beta} Cells.
L. A. Stephens, H. E. Thomas, L. Ming, M. Grell RIMA DARWICHE, L. Volodin, and T. W. H. Kay (1999)
Endocrinology 140, 3219-3227
   Abstract »    Full Text »
Activation of Caspase-3 in the Retina of Transgenic Rats with the Rhodopsin Mutation S334ter during Photoreceptor Degeneration.
C. Liu, Y. Li, M. Peng, A. M. Laties, and R. Wen (1999)
J. Neurosci. 19, 4778-4785
   Abstract »    Full Text »    PDF »
Characterization of the Interleukin-1ß-Converting Enzyme/Ced-3-Family Protease, Caspase-3/CPP32, in Hodgkin's Disease : Lack of Caspase-3 Expression in Nodular Lymphocyte Predominance Hodgkin's Disease.
K. F. Izban, T. Wrone-Smith, E. D. Hsi, B. Schnitzer, M. E. Quevedo, and S. Alkan (1999)
Am. J. Pathol. 154, 1439-1447
   Abstract »    Full Text »    PDF »
The baculovirus antiapoptotic p35 gene also functions via an oxidant-dependent pathway.
N. K. Sah, T. K. Taneja, N. Pathak, R. Begum, M. Athar, and S. E. Hasnain (1999)
PNAS 96, 4838-4843
   Abstract »    Full Text »    PDF »
The proapoptotic function of Drosophila Hid is conserved in mammalian cells.
W. N. Haining, C. Carboy-Newcomb, C. L. Wei, and H. Steller (1999)
PNAS 96, 4936-4941
   Abstract »    Full Text »    PDF »
Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis by DNA Damage.
Y. Huang, S. Nakada, T. Ishiko, T. Utsugisawa, R. Datta, S. Kharbanda, K. Yoshida, R. V. Talanian, R. Weichselbaum, D. Kufe, et al. (1999)
Mol. Cell. Biol. 19, 2986-2997
   Abstract »    Full Text »    PDF »
Bcl-xL Blocks Activation of Related Adhesion Focal Tyrosine Kinase/Proline-rich Tyrosine Kinase 2 and Stress-activated Protein Kinase/c-Jun N-terminal Protein Kinase in the Cellular Response to Methylmethane Sulfonate.
P. Pandey, S. Avraham, A. Place, V. Kumar, P. K. Majumder, K. Cheng, A. Nakazawa, S. Saxena, and S. Kharbanda (1999)
J. Biol. Chem. 274, 8618-8623
   Abstract »    Full Text »    PDF »
Upregulation of Superoxide Dismutase and Nitric Oxide Synthase Mediates the Apoptosis-Suppressive Effects of Shear Stress on Endothelial Cells.
S. Dimmeler, C. Hermann, J. Galle, and A. M. Zeiher (1999)
Arterioscler Thromb Vasc Biol 19, 656-664
   Abstract »    Full Text »    PDF »
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation.
K. Kobayashi, M. Hatano, M. Otaki, T. Ogasawara, and T. Tokuhisa (1999)
PNAS 96, 1457-1462
   Abstract »    Full Text »    PDF »
Baculovirus p33 Binds Human p53 and Enhances p53-Mediated Apoptosis.
G. G. Prikhod'ko, Y. Wang, E. Freulich, C. Prives, and L. K. Miller (1999)
J. Virol. 73, 1227-1234
   Abstract »    Full Text »
Isolation of an Apoptosis Suppressor Gene of the Spodoptera littoralis Nucleopolyhedrovirus.
Q. Du, D. Lehavi, O. Faktor, Y. Qi, and N. Chejanovsky (1999)
J. Virol. 73, 1278-1285
   Abstract »    Full Text »
IAP family proteins---suppressors of apoptosis.
Q. L. Deveraux and J. C. Reed (1999)
Genes & Dev. 13, 239-252
   Full Text »
A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis.
D.-W. Seol and T. R. Billiar (1999)
J. Biol. Chem. 274, 2072-2076
   Abstract »    Full Text »    PDF »
Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: Implicated mechanisms for caspase activation.
H. Kanuka, S. Hisahara, K. Sawamoto, S.-i. Shoji, H. Okano, and M. Miura (1999)
PNAS 96, 145-150
   Abstract »    Full Text »    PDF »
Cell death and cell protection genes determine the fate of pistils in maize.
A Calderon-Urrea and S. Dellaporta (1999)
Development 126, 435-441
   Abstract »    PDF »
Interferon Regulatory Factors Regulate Interleukin-1ß–Converting Enzyme Expression and Apoptosis in Vascular Smooth Muscle Cells.
M. Horiuchi, H. Yamada, M. Akishita, M. Ito, K. Tamura, and V. J. Dzau (1999)
Hypertension 33, 162-166
   Abstract »    Full Text »    PDF »
A Mutational Analysis of the Baculovirus Inhibitor of Apoptosis Op-IAP.
D. Vucic, W. J. Kaiser, and L. K. Miller (1998)
J. Biol. Chem. 273, 33915-33921
   Abstract »    Full Text »    PDF »
Bcl-2 Prevents Caspase-independent Cell Death.
S.-i. Okuno, S. Shimizu, T. Ito, M. Nomura, E. Hamada, Y. Tsujimoto, and H. Matsuda (1998)
J. Biol. Chem. 273, 34272-34277
   Abstract »    Full Text »    PDF »
Nineteen Baculovirus Open Reading Frames, Including LEF-12, Support Late Gene Expression.
J. C. Rapp, J. A. Wilson, and L. K. Miller (1998)
J. Virol. 72, 10197-10206
   Abstract »    Full Text »    PDF »
DEFT, a Novel Death Effector Domain-Containing Molecule Predominantly Expressed in Testicular Germ Cells.
C. P. Leo, S. Y. Hsu, E. A. McGee, M. Salanova, and A. J. W. Hsueh (1998)
Endocrinology 139, 4839-4848
   Abstract »    Full Text »    PDF »
Selective Regulation of Apoptosis: the Cytotoxic Lymphocyte Serpin Proteinase Inhibitor 9 Protects against Granzyme B-Mediated Apoptosis without Perturbing the Fas Cell Death Pathway.
C. H. Bird, V. R. Sutton, J. Sun, C. E. Hirst, A. Novak, S. Kumar, J. A. Trapani, and P. I. Bird (1998)
Mol. Cell. Biol. 18, 6387-6398
   Abstract »    Full Text »
Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cdelta : Implications for Apoptosis.
A. Bharti, S.-K. Kraeft, M. Gounder, P. Pandey, S. Jin, Z.-M. Yuan, S. P. Lees-Miller, R. Weichselbaum, D. Weaver, L. B. Chen, et al. (1998)
Mol. Cell. Biol. 18, 6719-6728
   Abstract »    Full Text »
Role of superoxide in apoptosis induced by growth factor withdrawal.
W. Lieberthal, V. Triaca, J. S. Koh, P. J. Pagano, and J. S. Levine (1998)
Am J Physiol Renal Physiol 275, F691-F702
   Abstract »    Full Text »    PDF »
Ceramide Generation by the Reaper Protein Is Not Blocked by the Caspase Inhibitor, p35.
R. Bose, P. Chen, A. Loconti, C. Grullich, J. M. Abrams, and R. N. Kolesnick (1998)
J. Biol. Chem. 273, 28852-28859
   Abstract »    Full Text »    PDF »
Nitric Oxide Prevents IL-1{beta} and IFN-{gamma}-Inducing Factor (IL-18) Release from Macrophages by Inhibiting Caspase-1 (IL-1{beta}-Converting Enzyme).
Y.-M. Kim, R. V. Talanian, J. Li, and T. R. Billiar (1998)
J. Immunol. 161, 4122-4128
   Abstract »    Full Text »    PDF »
Caspase Dependence of Target Cell Damage Induced by Cytotoxic Lymphocytes.
A. Sarin, E. K. Haddad, and P. A. Henkart (1998)
J. Immunol. 161, 2810-2816
   Abstract »    Full Text »    PDF »
Apoptosis Induced by Drosophila Reaper and Grim in a Human System. ATTENUATION BY INHIBITOR OF APOPTOSIS PROTEINS (cIAPs).
J. V. McCarthy and V. M. Dixit (1998)
J. Biol. Chem. 273, 24009-24015
   Abstract »    Full Text »    PDF »
Simultaneous Degradation of alpha II- and beta II-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells.
K. K. W. Wang, R. Posmantur, R. Nath, K. McGinnis, M. Whitton, R. V. Talanian, S. B. Glantz, and J. S. Morrow (1998)
J. Biol. Chem. 273, 22490-22497
   Abstract »    Full Text »    PDF »
Caspases: Enemies Within.
N. A. Thornberry and Y. Lazebnik (1998)
Science 281, 1312-1316
   Abstract »    Full Text »
A cloning method for caspase substrates that uses the yeast two-hybrid system: Cloning of the antiapoptotic gene gelsolin.
S. Kamada, H. Kusano, H. Fujita, M. Ohtsu, R. C. Koya, N. Kuzumaki, and Y. Tsujimoto (1998)
PNAS 95, 8532-8537
   Abstract »    Full Text »    PDF »
NF-kappa B-Mediated Inhibition of Apoptosis Is Required for Encephalomyocarditis Virus Virulence: a Mechanism of Resistance in p50 Knockout Mice.
E. M. Schwarz, C. Badorff, T. S. Hiura, R. Wessely, A. Badorff, I. M. Verma, and K. U. Knowlton (1998)
J. Virol. 72, 5654-5660
   Abstract »    Full Text »    PDF »
Proteasome Activation Occurs at an Early, Premitochondrial Step of Thymocyte Apoptosis.
T. Hirsch, B. Dallaporta, N. Zamzami, S. A. Susin, L. Ravagnan, I. Marzo, C. Brenner, and G. Kroemer (1998)
J. Immunol. 161, 35-40
   Abstract »    Full Text »    PDF »
ERICE, a Novel FLICE-activatable Caspase.
E. W. Humke, J. Ni, and V. M. Dixit (1998)
J. Biol. Chem. 273, 15702-15707
   Abstract »    Full Text »    PDF »
A Giant Ubiquitin-conjugating Enzyme Related to IAP Apoptosis Inhibitors.
H.-P. Hauser, M. Bardroff, G. Pyrowolakis, and S. Jentsch (1998)
J. Cell Biol. 141, 1415-1422
   Abstract »    Full Text »    PDF »
Inhibitor of Apoptosis Proteins Physically Interact with and Block Apoptosis Induced by Drosophila Proteins HID and GRIM.
D. Vucic, W. J. Kaiser, and L. K. Miller (1998)
Mol. Cell. Biol. 18, 3300-3309
   Abstract »    Full Text »
Proteases to die for.
V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
   Full Text »
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
T. Koseki, N. Inohara, S. Chen, and G. Nunez (1998)
PNAS 95, 5156-5160
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)