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Science 22 September 1995:
Vol. 269. no. 5231, pp. 1730 - 1734
DOI: 10.1126/science.7569903
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Articles

Science, Vol 269, Issue 5231, 1730-1734
Copyright © 1995 by American Association for the Advancement of Science

articles

Regulation of hippocampal transmitter release during development and long-term potentiation

VY Bolshakov and SA Siegelbaum

Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Developmental changes in rat hippocampal transmitter release and synaptic plasticity were investigated. Recordings from pairs of pyramidal neurons in slices showed that an action potential in a CA3 neuron released only a single quantum of transmitter onto a CA1 neuron. Failures of synaptic transmission reflected probabilistic transmitter release. The probability of release (Pr) was 0.9 in 4- to 8-day-old rats and decreased to less than 0.5 at 2 to 3 weeks. Long-term potentiation (LTP) in 2- to 3-week-old rats was associated with an increase in Pr from a single synaptic site. The high initial Pr in 4- to 8-day-old rats normally occludes the expression of LTP at this stage.


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