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Science 22 September 1995:
Vol. 269. no. 5231, pp. 1727 - 1730
DOI: 10.1126/science.7569902

Articles

Science, Vol 269, Issue 5231, 1727-1730
Copyright © 1995 by American Association for the Advancement of Science


articles

Activation of dual T cell signaling pathways by the chemokine RANTES

KB Bacon, BA Premack, P Gardner, and TJ Schall

Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.

The chemokine RANTES induced biphasic mobilization of Ca2+ in T cells. The initial peak, a transient increase in cytosolic Ca2+ mediated by a heterotrimeric guanine nucleotide-binding protein (G protein)--coupled pathway, was associated predominantly with chemotaxis. The second peak, Ca2+ release and sustained influx dependent on protein tyrosine kinases, was associated with a spectrum of cellular responses--Ca2+ channel opening, interleukin-2 receptor expression, cytokine release, and T cell proliferation--characteristic of T cell receptor activation. Other chemokines did not produce these responses. Thus, in addition to inducing chemotaxis, RANTES can act as an antigen-independent activator of T cells in vitro.


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   Abstract »    Full Text »    PDF »
Aggregation of RANTES Is Responsible for Its Inflammatory Properties. CHARACTERIZATION OF NONAGGREGATING, NONINFLAMMATORY RANTES MUTANTS.
V. Appay, A. Brown, S. Cribbes, E. Randle, and L. G. Czaplewski (1999)
J. Biol. Chem. 274, 27505-27512
   Abstract »    Full Text »    PDF »
Reciprocal Desensitization of CCR5 and CD4 Is Mediated by IL-16 and Macrophage-Inflammatory Protein-1{beta}, Respectively.
M. V. Mashikian, T. C. Ryan, A. Seman, W. Brazer, D. M. Center, and W. W. Cruikshank (1999)
J. Immunol. 163, 3123-3130
   Abstract »    Full Text »    PDF »
Selective Diapedesis of Th1 Cells Induced by Endothelial Cell RANTES.
T. Kawai, M. Seki, K. Hiromatsu, J. W. Eastcott, G. F. M. Watts, M. Sugai, D. J. Smith, S. A. Porcelli, and M. A. Taubman (1999)
J. Immunol. 163, 3269-3278
   Abstract »    Full Text »    PDF »
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.
A. B. H. Bakker, E. Baker, G. R. Sutherland, J. H. Phillips, and L. L. Lanier (1999)
PNAS 96, 9792-9796
   Abstract »    Full Text »    PDF »
The CC-Chemokine RANTES Increases the Attachment of Human Immunodeficiency Virus Type 1 to Target Cells via Glycosaminoglycans and Also Activates a Signal Transduction Pathway That Enhances Viral Infectivity.
A. Trkola, C. Gordon, J. Matthews, E. Maxwell, T. Ketas, L. Czaplewski, A. E. I. Proudfoot, and J. P. Moore (1999)
J. Virol. 73, 6370-6379
   Abstract »    Full Text »
Reduced Risk of AIDS Lymphoma in Individuals Heterozygous for the CCR5-{{Delta}}32 Mutation.
M. Dean, L. P. Jacobson, G. McFarlane, J. B. Margolick, F. J. Jenkins, O. M. Z. Howard, H.-F. Dong, J. J. Goedert, S. Buchbinder, E. Gomperts, et al. (1999)
Cancer Res. 59, 3561-3564
   Abstract »    Full Text »    PDF »
Characterization of Fractalkine in Rat Brain Cells: Migratory and Activation Signals for CX3CR-1-Expressing Microglia.
D. Maciejewski-Lenoir, S. Chen, L. Feng, R. Maki, and K. B. Bacon (1999)
J. Immunol. 163, 1628-1635
   Abstract »    Full Text »    PDF »
Gi Proteins Use a Novel beta gamma - and Ras-independent Pathway to Activate Extracellular Signal-regulated Kinase and Mobilize AP-1 Transcription Factors in Jurkat T Lymphocytes.
K. E. Hedin, M. P. Bell, C. J. Huntoon, L. M. Karnitz, and D. J. McKean (1999)
J. Biol. Chem. 274, 19992-20001
   Abstract »    Full Text »    PDF »
Induction of Phosphorylation and Intracellular Association of CC Chemokine Receptor 5 and Focal Adhesion Kinase in Primary Human CD4+ T Cells by Macrophage-Tropic HIV Envelope.
C. Cicala, J. Arthos, M. Ruiz, M. Vaccarezza, A. Rubbert, A. Riva, K. Wildt, O. Cohen, and A. S. Fauci (1999)
J. Immunol. 163, 420-426
   Abstract »    Full Text »    PDF »
Interleukin-18, Interferon-{gamma}, IP-10, and Mig Expression in Epstein-Barr Virus-Induced Infectious Mononucleosis and Posttransplant Lymphoproliferative Disease.
J. Setsuda, J. Teruya-Feldstein, N. L. Harris, J. A. Ferry, L. Sorbara, G. Gupta, E. S. Jaffe, and G. Tosato (1999)
Am. J. Pathol. 155, 257-265
   Abstract »    Full Text »    PDF »
Human Thymocytes Express CCR-3 and Are Activated by Eotaxin.
K. Franz-Bacon, D. J. Dairaghi, S. A. Boehme, S. K. Sullivan, T. J. Schall, P. J. Conlon, N. Taylor, and K. B. Bacon (1999)
Blood 93, 3233-3240
   Abstract »    Full Text »    PDF »
Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization.
T. Koga, E. Sardina, R. M. Tidwell, M. Pelletier, D. C. Look, and M. J. Holtzman (1999)
PNAS 96, 5680-5685
   Abstract »    Full Text »    PDF »
Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4.
T. Jinquan, S. Quan, G. Feili, C. G. Larsen, and K. Thestrup-Pedersen (1999)
J. Immunol. 162, 4285-4292
   Abstract »    Full Text »    PDF »
Similarities and Differences in RANTES- and (AOP)-RANTES-triggered Signals: Implications for Chemotaxis.
J. M. Rodriguez-Frade, A. J. Vila-Coro, A. Martin, M. Nieto, F. Sanchez-Madrid, A. E.I. Proudfoot, T. N.C. Wells, C. Martinez-A, and M. Mellado (1999)
J. Cell Biol. 144, 755-765
   Abstract »    Full Text »    PDF »
Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization.
M. D. Gunn, S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano (1999)
J. Exp. Med. 189, 451-460
   Abstract »    Full Text »    PDF »
Eradication of Pre-Established Lymphoma Using Herpes Simplex Virus Amplicon Vectors.
M. Kutubuddin, H. J. Federoff, P. M. Challita-Eid, M. Halterman, B. Day, M. Atkinson, V. Planelles, and J. D. Rosenblatt (1999)
Blood 93, 643-654
   Abstract »    Full Text »    PDF »
Association of Rhinovirus Infections with Asthma.
J. E. Gern and W. W. Busse (1999)
Clin. Microbiol. Rev. 12, 9-18
   Abstract »    Full Text »    PDF »
Enhancement of Human Immunodeficiency Virus Type 1 Infection by the CC-Chemokine RANTES Is Independent of the Mechanism of Virus-Cell Fusion.
C. J. Gordon, M. A. Muesing, A. E. I. Proudfoot, C. A. Power, J. P. Moore, and A. Trkola (1999)
J. Virol. 73, 684-694
   Abstract »    Full Text »    PDF »
Degree of TCR Internalization and Ca2+ Flux Correlates with Thymocyte Selection.
S. Mariathasan, M. F. Bachmann, D. Bouchard, T. Ohteki, and P. S. Ohashi (1998)
J. Immunol. 161, 6030-6037
   Abstract »    Full Text »    PDF »
The Selective Inhibition of {beta}1 and {beta}7 Integrin-Mediated Lymphocyte Adhesion by Bacitracin.
Y. Mou, H. Ni, and J. A. Wilkins (1998)
J. Immunol. 161, 6323-6329
   Abstract »    Full Text »    PDF »



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