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Science 15 September 1995:
Vol. 269. no. 5230, pp. 1583 - 1585
DOI: 10.1126/science.7667639

Articles

Science, Vol 269, Issue 5230, 1583-1585
Copyright © 1995 by American Association for the Advancement of Science


articles

Requirement of MIP-1 alpha for an inflammatory response to viral infection

DN Cook, MA Beck, TM Coffman, SL Kirby, JF Sheridan, IB Pragnell, and O Smithies

Department of Pathology, University of North Carolina, Chapel Hill 27599-7525, USA.

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.


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P. Proost, P. Menten, S. Struyf, E. Schutyser, I. De Meester, and J. Van Damme (2000)
Blood 96, 1674-1680
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Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells: Absence of Ccr2 Shifts the Leishmania major-Resistant Phenotype to a Susceptible State Dominated by Th2 Cytokines, B Cell Outgrowth, and Sustained Neutrophilic Inflammation.
N. Sato, S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja (2000)
J. Exp. Med. 192, 205-218
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Macrophage Inflammatory Protein-1{alpha} Is a Critical Mediator of Host Defense Against Invasive Pulmonary Aspergillosis in Neutropenic Hosts.
B. Mehrad, T. A. Moore, and T. J. Standiford (2000)
J. Immunol. 165, 962-968
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Differential Expression of CC Chemokines and the CCR5 Receptor in the Pancreas Is Associated with Progression to Type I Diabetes.
M. J. Cameron, G. A. Arreaza, M. Grattan, C. Meagher, S. Sharif, M. D. Burdick, R. M. Strieter, D. N. Cook, and T. L. Delovitch (2000)
J. Immunol. 165, 1102-1110
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Depletion of Lymphocytes and Diminished Cytokine Production in Mice Infected with a Highly Virulent Influenza A (H5N1) Virus Isolated from Humans.
T. M. Tumpey, X. Lu, T. Morken, S. R. Zaki, and J. M. Katz (2000)
J. Virol. 74, 6105-6116
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Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine.
P. G. Andres, P. L. Beck, E. Mizoguchi, A. Mizoguchi, A. K. Bhan, T. Dawson, W. A. Kuziel, N. Maeda, R. P. MacDermott, D. K. Podolsky, et al. (2000)
J. Immunol. 164, 6303-6312
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Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus.
T. C. Dawson, M. A. Beck, W. A. Kuziel, F. Henderson, and N. Maeda (2000)
Am. J. Pathol. 156, 1951-1959
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Type I IFN Modulates Innate and Specific Antiviral Immunity.
J. E. Durbin, A. Fernandez-Sesma, C.-K. Lee, T. D. Rao, A. B. Frey, T. M. Moran, S. Vukmanovic, A. Garcia-Sastre, and D. E. Levy (2000)
J. Immunol. 164, 4220-4228
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Therapeutic Effect of Anti-Macrophage Inflammatory Protein 2 Antibody on Influenza Virus-Induced Pneumonia in Mice.
S. Sakai, H. Kawamata, N. Mantani, T. Kogure, Y. Shimada, K. Terasawa, T. Sakai, N. Imanishi, and H. Ochiai (2000)
J. Virol. 74, 2472-2476
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International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors.
P. M. Murphy, M. Baggiolini, I. F. Charo, C. A. Hebert, R. Horuk, K. Matsushima, L. H. Miller, J. J. Oppenheim, and C. A. Power (2000)
Pharmacol. Rev. 52, 145-176
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Chemokines and Cell Migration in Secondary Lymphoid Organs.
J. G. Cyster (1999)
Science 286, 2098-2102
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The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor.
G. Camarda, G. Spinetti, G. Bernardini, C. Mair, N. Davis-Poynter, M. C. Capogrossi, and M. Napolitano (1999)
J. Virol. 73, 9843-9848
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Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures.
D. L. Noah, M. A. Blum, and B. Sherry (1999)
J. Virol. 73, 10208-10213
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Inducible Nitric Oxide Synthase Protection Against Coxsackievirus Pancreatitis.
C. Zaragoza, C. J. Ocampo, M. Saura, C. Bao, M. Leppo, A. Lafond-Walker, D. R. Thiemann, R. Hruban, and C. J. Lowenstein (1999)
J. Immunol. 163, 5497-5504
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Defects in the Generation of IFN-{gamma} Are Overcome to Control Infection with Leishmania donovani in CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1{alpha}-, or CCR2-Deficient Mice.
N. Sato, W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja (1999)
J. Immunol. 163, 5519-5525
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Differential Regulation of Epithelial-Derived C-C Chemokine Expression by IL-4 and the Glucocorticoid Budesonide.
C. Stellato, S. Matsukura, A. Fal, J. White, L. A. Beck, D. Proud, and R. P. Schleimer (1999)
J. Immunol. 163, 5624-5632
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Integrating Conflicting Chemotactic Signals: The Role of Memory in Leukocyte Navigation.
E. F. Foxman, E. J. Kunkel, and E. C. Butcher (1999)
J. Cell Biol. 147, 577-588
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Strong Cytotoxic T Lymphocyte Responses to a Macrophage Inflammatory Protein 1{{alpha}}-expressing Tumor: Linkage between Inflammation and Specific Immunity.
M. Maric and Y. Liu (1999)
Cancer Res. 59, 5549-5553
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beta -Chemokines Enhance Parasite Uptake and Promote Nitric Oxide-Dependent Microbiostatic Activity in Murine Inflammatory Macrophages Infected with Trypanosoma cruzi.
J. C. S. Aliberti, F. S. Machado, J. T. Souto, A. P. Campanelli, M. M. Teixeira, R. T. Gazzinelli, and J. S. Silva (1999)
Infect. Immun. 67, 4819-4826
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