Science 1 September 1995: Vol. 269. no. 5228, pp. 1281 - 1284 DOI: 10.1126/science.7652577

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Articles

A Novel Class of Cyclin-dependent Kinase Inhibitors Identified by Molecular Docking Act through a Unique Mechanism.

P. Corsino, N. Horenstein, D. Ostrov, T. Rowe, M. Law, A. Barrett, G. Aslanidi, W. D. Cress, and B. Law (2009)
J. Biol. Chem. 284, 29945-29955
 |  Abstract »  |  Full Text »  |  PDF »

Complete Regression of Advanced Primary and Metastatic Mouse Melanomas following Combination Chemoimmunotherapy.

J. Kohlmeyer, M. Cron, J. Landsberg, T. Bald, M. Renn, S. Mikus, S. Bondong, D. Wikasari, E. Gaffal, G. Hartmann, et al. (2009)
Cancer Res. 69, 6265-6274
 |  Abstract »  |  Full Text »  |  PDF »

Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4+ T Cells.

A. Corthay, K. U. Lundin, K. B. Lorvik, P. O. Hofgaard, and B. Bogen (2009)
Cancer Res. 69, 5901-5907
 |  Abstract »  |  Full Text »  |  PDF »

Immune Rejection of Mouse Tumors Expressing Mutated Self.

F. Duan, Y. Lin, C. Liu, M. E. Engelhorn, A. D. Cohen, M. Curran, S. Sakaguchi, T. Merghoub, S. Terzulli, J. D. Wolchok, et al. (2009)
Cancer Res. 69, 3545-3553
 |  Abstract »  |  Full Text »  |  PDF »

Crystal structure of human CDK4 in complex with a D-type cyclin.

P. J. Day, A. Cleasby, I. J. Tickle, M. O'Reilly, J. E. Coyle, F. P. Holding, R. L. McMenamin, J. Yon, R. Chopra, C. Lengauer, et al. (2009)
PNAS 106, 4166-4170
 |  Abstract »  |  Full Text »  |  PDF »

CD8 T-cell Responses against Cyclin B1 in Breast Cancer Patients with Tumors Overexpressing p53.

R. B. Sorensen, R. S. Andersen, I. M. Svane, L. Engell-Noerregaard, S. R. Hadrup, E. Balslev, M. H. Andersen, and P. t. Straten (2009)
Clin. Cancer Res. 15, 1543-1549
 |  Abstract »  |  Full Text »  |  PDF »

MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency.

Y. Godet, A. Moreau-Aubry, Y. Guilloux, V. Vignard, A. Khammari, B. Dreno, F. Jotereau, and N. Labarriere (2008)
J. Exp. Med. 205, 2673-2682
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D1-Specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy.

E. Kondo, B. Maecker, M. R. Weihrauch, C. Wickenhauser, W. Zeng, L. M. Nadler, J. L. Schultze, and M. S. von Bergwelt-Baildon (2008)
Clin. Cancer Res. 14, 6574-6579
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase 3-Mediated Activating Transcription Factor 1 Phosphorylation Enhances Cell Transformation.

D. Zheng, Y.-Y. Cho, A. T.Y. Lau, J. Zhang, W.-Y. Ma, A. M. Bode, and Z. Dong (2008)
Cancer Res. 68, 7650-7660
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression.

K. S.M. Smalley, R. Contractor, T. K. Nguyen, M. Xiao, R. Edwards, V. Muthusamy, A. J. King, K. T. Flaherty, M. Bosenberg, M. Herlyn, et al. (2008)
Cancer Res. 68, 5743-5752
 |  Abstract »  |  Full Text »  |  PDF »

Malignant Melanoma in the 21st Century: The Emerging Molecular Landscape.

A. Sekulic, P. Haluska Jr, A. J. Miller, J. G. De Lamo, S. Ejadi, J. S. Pulido, D. R. Salomao, E. C. Thorland, R. G. Vile, D. L. Swanson, et al. (2008)
Mayo Clin. Proc. 83, 825-846
 |  Abstract »  |  Full Text »  |  PDF »

Epitope Landscape in Breast and Colorectal Cancer.

N. H. Segal, D. W. Parsons, K. S. Peggs, V. Velculescu, K. W. Kinzler, B. Vogelstein, and J. P. Allison (2008)
Cancer Res. 68, 889-892
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase 4 Hyperactivity Promotes Autoreactivity in the Immune System but Protects Pancreatic Cell Mass from Autoimmune Destruction in the Nonobese Diabetic Mouse Model.

N. Marzo, S. Ortega, T. Stratmann, A. Garcia, M. Rios, A. Gimenez, R. Gomis, and C. Mora (2008)
J. Immunol. 180, 1189-1198
 |  Abstract »  |  Full Text »  |  PDF »

A CDKN2A Mutation in Familial Melanoma that Abrogates Binding of p16INK4a to CDK4 but not CDK6.

R. Jones, M. Ruas, F. Gregory, S. Moulin, D. Delia, S. Manoukian, J. Rowe, S. Brookes, and G. Peters (2007)
Cancer Res. 67, 9134-9141
 |  Abstract »  |  Full Text »  |  PDF »

Immunologic Approaches to Ovarian Cancer Treatment.

P. Sabbatini and K. Odunsi (2007)
J. Clin. Oncol. 25, 2884-2893
 |  Abstract »  |  Full Text »  |  PDF »

CDK4 and CDK6 Delay Senescence by Kinase-Dependent and p16INK4a-Independent Mechanisms.

M. Ruas, F. Gregory, R. Jones, R. Poolman, M. Starborg, J. Rowe, S. Brookes, and G. Peters (2007)
Mol. Cell. Biol. 27, 4273-4282
 |  Abstract »  |  Full Text »  |  PDF »

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials.

G. Parmiani, A. De Filippo, L. Novellino, and C. Castelli (2007)
J. Immunol. 178, 1975-1979
 |  Abstract »  |  Full Text »  |  PDF »

Nucleocytoplasmic Shuttling of the Retinoblastoma Tumor Suppressor Protein via Cdk Phosphorylation-dependent Nuclear Export.

W. Jiao, J. Datta, H.-M. Lin, M. Dundr, and S. G. Rane (2006)
J. Biol. Chem. 281, 38098-38108
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Action of the Retinoblastoma Pathway on the DNA Replication Machinery Defines Specific Roles for Cyclin-Dependent Kinase Complexes in Prereplication Complex Assembly and S-Phase Progression.

W. A. Braden, J. M. Lenihan, Z. Lan, K. S. Luce, W. Zagorski, E. Bosco, M. F. Reed, J. G. Cook, and E. S. Knudsen (2006)
Mol. Cell. Biol. 26, 7667-7681
 |  Abstract »  |  Full Text »  |  PDF »

Oncogene-induced cell senescence--halting on the road to cancer..

W.J. Mooi and D.S. Peeper (2006)
N. Engl. J. Med. 355, 1037-1046
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Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell-Mediated Patient-Specific Immunotherapy.

M. Sensi and A. Anichini (2006)
Clin. Cancer Res. 12, 5023-5032
 |  Abstract »  |  Full Text »  |  PDF »

Malignant melanoma: genetics and therapeutics in the genomic era..

L. Chin, L. A. Garraway, and D. E. Fisher (2006)
Genes & Dev. 20, 2149-2182
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Growth of Invasive Metastatic Melanoma in Carcinogen-Treated Hepatocyte Growth Factor/Scatter Factor-Transgenic Mice Carrying an Oncogenic CDK4 Mutation.

D. Tormo, A. Ferrer, E. Gaffal, J. Wenzel, E. Basner-Tschakarjan, J. Steitz, L. C. Heukamp, I. Gutgemann, R. Buettner, M. Malumbres, et al. (2006)
Am. J. Pathol. 169, 665-672
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic Efficacy of Antigen-Specific Vaccination and Toll-Like Receptor Stimulation against Established Transplanted and Autochthonous Melanoma in Mice..

D. Tormo, A. Ferrer, P. Bosch, E. Gaffal, E. Basner-Tschakarjan, J. Wenzel, and T. Tuting (2006)
Cancer Res. 66, 5427-5435
 |  Abstract »  |  Full Text »  |  PDF »

Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression..

Z.-J. Liu, M. Xiao, K. Balint, K. S.M. Smalley, P. Brafford, R. Qiu, C. C. Pinnix, X. Li, and M. Herlyn (2006)
Cancer Res. 66, 4182-4190
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of S/G2 Phase CDK4 Reduces Mitotic Fidelity.

A. Burgess, M. Wigan, N. Giles, W. DePinto, P. Gillespie, F. Stevens, and B. Gabrielli (2006)
J. Biol. Chem. 281, 9987-9995
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment.

G. I. Shapiro (2006)
J. Clin. Oncol. 24, 1770-1783
 |  Abstract »  |  Full Text »  |  PDF »

Recognition of Cancer by the Immune System.

A. N. Houghton (2006)
Am. Assoc. Cancer Res. Educ. Book 2006, 91-94
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Well-Defined Melanoma Antigens as Progression Markers for Melanoma: Insights into Differential Expression and Host Response Based on Stage.

F. S. Hodi (2006)
Clin. Cancer Res. 12, 673-678
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A Network of Genetic Events Sufficient to Convert Normal Human Cells to a Tumorigenic State.

S. D. Kendall, C. M. Linardic, S. J. Adam, and C. M. Counter (2005)
Cancer Res. 65, 9824-9828
 |  Abstract »  |  Full Text »  |  PDF »

The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.

V. Lennerz, M. Fatho, C. Gentilini, R. A. Frye, A. Lifke, D. Ferel, C. Wolfel, C. Huber, and T. Wolfel (2005)
PNAS 102, 16013-16018
 |  Abstract »  |  Full Text »  |  PDF »

Turning On/Off Tumor-Specific CTL Response during Progressive Tumor Growth.

Y. Huang, N. Obholzer, R. Fayad, and L. Qiao (2005)
J. Immunol. 175, 3110-3116
 |  Abstract »  |  Full Text »  |  PDF »

MC1R, ASIP, and DNA Repair in Sporadic and Familial Melanoma in a Mediterranean Population.

M. T. Landi, P. A. Kanetsky, S. Tsang, B. Gold, D. Munroe, T. Rebbeck, J. Swoyer, M. Ter-Minassian, M. Hedayati, L. Grossman, et al. (2005)
J Natl Cancer Inst 97, 998-1007
 |  Abstract »  |  Full Text »  |  PDF »

E2F-Dependent Repression of Topoisomerase II Regulates Heterochromatin Formation and Apoptosis in Cells with Melanoma-Prone Mutation.

W. Jiao, H.-M. Lin, J. Timmons, A. K. Nagaich, S.-W. Ng, T. Misteli, and S. G. Rane (2005)
Cancer Res. 65, 4067-4077
 |  Abstract »  |  Full Text »  |  PDF »

Cooperation between Cdk4 and p27kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity.

R. Sotillo, O. Renner, P. Dubus, J. Ruiz-Cabello, J. Martin-Caballero, M. Barbacid, A. Carnero, and M. Malumbres (2005)
Cancer Res. 65, 3846-3852
 |  Abstract »  |  Full Text »  |  PDF »

CDK4 and MDM2 Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-type INK4a/ARF Locus.

L. Hernandez, S. Bea, M. Pinyol, G. Ott, T. Katzenberger, A. Rosenwald, F. Bosch, A. Lopez-Guillermo, J. Delabie, D. Colomer, et al. (2005)
Cancer Res. 65, 2199-2206
 |  Abstract »  |  Full Text »  |  PDF »

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors.

P. Yu, Y. Lee, W. Liu, T. Krausz, A. Chong, H. Schreiber, and Y.-X. Fu (2005)
J. Exp. Med. 201, 779-791
 |  Abstract »  |  Full Text »  |  PDF »

The Growth Arrest Function of the Human Oncoprotein Mouse Double Minute-2 Is Disabled by Downstream Mutation in Cancer Cells.

R. Zhou, R. Frum, S. Deb, and S. P. Deb (2005)
Cancer Res. 65, 1839-1848
 |  Abstract »  |  Full Text »  |  PDF »

Human Papillomavirus Oncoprotein E7 Targets the Promyelocytic Leukemia Protein and Circumvents Cellular Senescence via the Rb and p53 Tumor Suppressor Pathways.

O. Bischof, K. Nacerddine, and A. Dejean (2005)
Mol. Cell. Biol. 25, 1013-1024
 |  Abstract »  |  Full Text »  |  PDF »

High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumor antigens.

C. Germeau, W. Ma, F. Schiavetti, C. Lurquin, E. Henry, N. Vigneron, F. Brasseur, B. Lethe, E. De Plaen, T. Velu, et al. (2005)
J. Exp. Med. 201, 241-248
 |  Abstract »  |  Full Text »  |  PDF »

Immunogenicity without Immunoselection: A Mutant but Functional Antioxidant Enzyme Retained in a Human Metastatic Melanoma and Targeted by CD8+ T Cells with a Memory Phenotype.

M. Sensi, G. Nicolini, M. Zanon, C. Colombo, A. Molla, I. Bersani, R. Lupetti, G. Parmiani, and A. Anichini (2005)
Cancer Res. 65, 632-640
 |  Abstract »  |  Full Text »  |  PDF »

Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes.

S. Pal, S. N. Vishwanath, H. Erdjument-Bromage, P. Tempst, and S. Sif (2004)
Mol. Cell. Biol. 24, 9630-9645
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Cyclin-Dependent Kinase 4 Inhibits c-myc Tumorigenic Activities in Epithelial Tissues.

P. L. Miliani de Marval, E. Macias, R. Rounbehler, P. Sicinski, H. Kiyokawa, D. G. Johnson, C. J. Conti, and M. L. Rodriguez-Puebla (2004)
Mol. Cell. Biol. 24, 7538-7547
 |  Abstract »  |  Full Text »  |  PDF »

Immunogenicity of Constitutively Active V599EBRaf.

M. H. Andersen, J. Fensterle, S. Ugurel, S. Reker, R. Houben, P. Guldberg, T. G. Berger, D. Schadendorf, U. Trefzer, E.-B. Brocker, et al. (2004)
Cancer Res. 64, 5456-5460
 |  Abstract »  |  Full Text »  |  PDF »

Genetic susceptibility in familial melanoma from northeastern Italy.

M T Landi, A M Goldstein, S Tsang, D Munroe, W Modi, M Ter-Minassian, R Steighner, M Dean, N Metheny, B Staats, et al. (2004)
J. Med. Genet. 41, 557-566
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Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4.

M. Wallace and K. L. Ball (2004)
Mol. Cell. Biol. 24, 5606-5619
 |  Abstract »  |  Full Text »  |  PDF »

T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product.

J. Huang, M. El-Gamil, M. E. Dudley, Y. F. Li, S. A. Rosenberg, and P. F. Robbins (2004)
J. Immunol. 172, 6057-6064
 |  Abstract »  |  Full Text »  |  PDF »

The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway.

S. R. Whittaker, M. I. Walton, M. D. Garrett, and P. Workman (2004)
Cancer Res. 64, 262-272
 |  Abstract »  |  Full Text »  |  PDF »

Progression in Cutaneous Malignant Melanoma Is Associated with Distinct Expression Profiles: A Tissue Microarray-Based Study.

S. R. Alonso, P. Ortiz, M. Pollan, B. Perez-Gomez, L. Sanchez, M. J. Acuna, R. Pajares, F. J. Martinez-Tello, C. M. Hortelano, M. A. Piris, et al. (2004)
Am. J. Pathol. 164, 193-203
 |  Abstract »  |  Full Text »  |  PDF »

On the Role of Unmutated Antigens in Tumor Rejection in Mice with Unperturbed T-cell Repertoires.

S. Sarma, X.-F. Bai, J.-q. Liu, K. F. May Jr., P. Zheng, and Y. Liu (2003)
Cancer Res. 63, 6051-6055
 |  Abstract »  |  Full Text »  |  PDF »

NY-ESO-1 and LAGE-1 Cancer-Testis Antigens Are Potential Targets for Immunotherapy in Epithelial Ovarian Cancer.

K. Odunsi, A. A. Jungbluth, E. Stockert, F. Qian, S. Gnjatic, J. Tammela, M. Intengan, A. Beck, B. Keitz, D. Santiago, et al. (2003)
Cancer Res. 63, 6076-6083
 |  Abstract »  |  Full Text »  |  PDF »

Disease Stage Variation in CD4+ and CD8+ T-Cell Reactivity to the Receptor Tyrosine Kinase EphA2 in Patients with Renal Cell Carcinoma.

T. Tatsumi, C. J. Herrem, W. C. Olson, J. H. Finke, R. M. Bukowski, M. S. Kinch, E. Ranieri, and W. J. Storkus (2003)
Cancer Res. 63, 4481-4489
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Cyclin-Dependent Kinase 6, but not Cyclin-Dependent Kinase 4, Alters Morphology of Cultured Mouse Astrocytes.

K. K. Ericson, D. Krull, P. Slomiany, and M. J. Grossel (2003)
Mol. Cancer Res. 1, 654-664
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Mutated Receptor-Like Protein Tyrosine Phosphatase {kappa} as a Novel, Class II HLA-Restricted Melanoma Antigen.

L. Novellino, N. Renkvist, F. Rini, A. Mazzocchi, L. Rivoltini, A. Greco, P. Deho, P. Squarcina, P. F. Robbins, G. Parmiani, et al. (2003)
J. Immunol. 170, 6363-6370
 |  Abstract »  |  Full Text »  |  PDF »

Mucin Gene Expression in Immortalized Human Corneal-Limbal and Conjunctival Epithelial Cell Lines.

I. K. Gipson, S. Spurr-Michaud, P. Argueso, A. Tisdale, T. F. Ng, and C. L. Russo (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2496-2506
 |  Abstract »  |  Full Text »  |  PDF »

Abolition of Cyclin-Dependent Kinase Inhibitor p16Ink4a and p21Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts.

W. Wei, W. A. Jobling, W. Chen, W. C. Hahn, and J. M. Sedivy (2003)
Mol. Cell. Biol. 23, 2859-2870
 |  Abstract »  |  Full Text »  |  PDF »

Dissecting the Contribution of p16INK4A and the Rb Family to the Ras Transformed Phenotype.

P. J. Mitchell, E. Perez-Nadales, D. S. Malcolm, and A. C. Lloyd (2003)
Mol. Cell. Biol. 23, 2530-2542
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis.

F. Bai, X.-H. Pei, V. L. Godfrey, and Y. Xiong (2003)
Mol. Cell. Biol. 23, 1269-1277
 |  Abstract »  |  Full Text »  |  PDF »

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.

X. Zou, D. Ray, A. Aziyu, K. Christov, A. D. Boiko, A. V. Gudkov, and H. Kiyokawa (2002)
Genes & Dev. 16, 2923-2934
 |  Abstract »  |  Full Text »  |  PDF »

cdk4 Deficiency Inhibits Skin Tumor Development but Does Not Affect Normal Keratinocyte Proliferation.

M. L. Rodriguez-Puebla, P. L. Miliani de Marval, M. LaCava, D. S. Moons, H. Kiyokawa, and C. J. Conti (2002)
Am. J. Pathol. 161, 405-411
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Vaccines.

I. Espinoza-Delgado (2002)
Oncologist 7, 20-33
 |  Abstract »  |  Full Text »  |  PDF »

A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status.

J. G. Rheinwald, W. C. Hahn, M. R. Ramsey, J. Y. Wu, Z. Guo, H. Tsao, M. De Luca, C. Catricala, and K. M. O'Toole (2002)
Mol. Cell. Biol. 22, 5157-5172
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of MTK1/MEKK4 Kinase Activity by Its N-Terminal Autoinhibitory Domain and GADD45 Binding.

H. Mita, J. Tsutsui, M. Takekawa, E. A. Witten, and H. Saito (2002)
Mol. Cell. Biol. 22, 4544-4555
 |  Abstract »  |  Full Text »  |  PDF »

Identification of HLA-A*0201-Restricted T Cell Epitopes Derived from the Novel Overexpressed Tumor Antigen Calcium-Activated Chloride Channel 2.

R. Konopitzky, U. Konig, R. G. Meyer, W. Sommergruber, T. Wolfel, and T. Schweighoffer (2002)
J. Immunol. 169, 540-547
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?.

G. Parmiani, C. Castelli, P. Dalerba, R. Mortarini, L. Rivoltini, F. M. Marincola, and A. Anichini (2002)
J Natl Cancer Inst 94, 805-818
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Mutated Fibronectin As a Tumor Antigen Recognized by CD4+T Cells: Its Role in Extracellular Matrix Formation and Tumor Metastasis.

H. Y. Wang, J. Zhou, K. Zhu, A. I. Riker, F. M. Marincola, and R.-F. Wang (2002)
J. Exp. Med. 195, 1397-1406
 |  Abstract »  |  Full Text »  |  PDF »

Cyclin D1 Is a Candidate Oncogene in Cutaneous Melanoma.

E. R. Sauter, U.-C. Yeo, A. von Stemm, W. Zhu, S. Litwin, D. S. Tichansky, G. Pistritto, M. Nesbit, D. Pinkel, M. Herlyn, et al. (2002)
Cancer Res. 62, 3200-3206
 |  Abstract »  |  Full Text »  |  PDF »

A ras-Mutated Peptide Targeted by CTL Infiltrating a Human Melanoma Lesion.

B. Linard, S. Bezieau, H. Benlalam, N. Labarriere, Y. Guilloux, E. Diez, and F. Jotereau (2002)
J. Immunol. 168, 4802-4808
 |  Abstract »  |  Full Text »  |  PDF »

Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation.

W. C. Hahn, S. K. Dessain, M. W. Brooks, J. E. King, B. Elenbaas, D. M. Sabatini, J. A. DeCaprio, and R. A. Weinberg (2002)
Mol. Cell. Biol. 22, 2111-2123
 |  Abstract »  |  Full Text »  |  PDF »

Toward Synthetic Combinatorial Peptide Libraries in Positional Scanning Format (PS-SCL)-based Identification of CD8+ Tumor-reactive T-Cell Ligands: A Comparative Analysis of PS-SCL Recognition by a Single Tumor-reactive CD8+ Cytolytic T-Lymphocyte Clone.

V. Rubio-Godoy, C. Pinilla, V. Dutoit, E. Borras, R. Simon, Y. Zhao, J.-C. Cerottini, P. Romero, R. Houghten, and D. Valmori (2002)
Cancer Res. 62, 2058-2063
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmunity to the Mr 32,000 Subunit of Replication Protein A in Breast Cancer.

J. E. Tomkiel, H. Alansari, N. Tang, J. B. Virgin, X. Yang, P. VandeVord, R. L. Karvonen, J. L. Granda, M. J. Kraut, J. F. Ensley, et al. (2002)
Clin. Cancer Res. 8, 752-758
 |  Abstract »  |  Full Text »  |  PDF »

Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence.

S. G. Rane, S. C. Cosenza, R. V. Mettus, and E. P. Reddy (2002)
Mol. Cell. Biol. 22, 644-656
 |  Abstract »  |  Full Text »  |  PDF »

Pre-Existing Immunity to Tyrosinase-Related Protein (TRP)-2, a New TRP-2 Isoform, and the NY-ESO-1 Melanoma Antigen in a Patient with a Dramatic Response to Immunotherapy.

H. T. Khong and S. A. Rosenberg (2002)
J. Immunol. 168, 951-956
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Cyclin B1 as a Shared Human Epithelial Tumor-Associated Antigen Recognized by T Cells.

H. Kao, J. A. Marto, T. K. Hoffmann, J. Shabanowitz, S. D. Finkelstein, T. L. Whiteside, D. F. Hunt, and O. J. Finn (2001)
J. Exp. Med. 194, 1313-1324
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Antigens Isolated from a Patient with Vitiligo and T-Cell-infiltrated Melanoma.

Y. Kiniwa, T. Fujita, M. Akada, K. Ito, T. Shofuda, Y. Suzuki, A. Yamamoto, T. Saida, and Y. Kawakami (2001)
Cancer Res. 61, 7900-7907
 |  Abstract »  |  Full Text »  |  PDF »

Immune Responses to the HLA-A*0201-Restricted Epitopes of Tyrosinase and Glycoprotein 100 Enable Control of Melanoma Outgrowth in HLA-A*0201-Transgenic Mice.

D. W. Mullins, T. N. J. Bullock, T. A. Colella, V. V. Robila, and V. H. Engelhard (2001)
J. Immunol. 167, 4853-4860
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Epidemiology of Cutaneous Melanoma: A Global Perspective.

A. M. Goldstein and M. A. Tucker (2001)
Arch Dermatol 137, 1493-1496
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Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer.

D Jager, E Jager, and A Knuth (2001)
J. Clin. Pathol. 54, 669-674
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutation in Essential Genes with Loss or Mutation of the Second Allele: Relevance to the Retention of Tumor-Specific Antigens.

G. B. Beck-Engeser, P. A. Monach, D. Mumberg, F. Yang, S. Wanderling, K. Schreiber, R. Espinosa III, M. M. Le Beau, S. C. Meredith, and H. Schreiber (2001)
J. Exp. Med. 194, 285-300
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant expression of G1/S regulators is a frequent event in sporadic pituitary adenomas.

D. J. Simpson, S. J. Frost, J. E. Bicknell, J. C. Broome, A. M. McNicol, R. N. Clayton, and W. E. Farrell (2001)
Carcinogenesis 22, 1149-1154
 |  Abstract »  |  Full Text »  |  PDF »

Heterogeneous T-Cell Response to MAGE-A10254-262: High Avidity-specific Cytolytic T Lymphocytes Show Superior Antitumor Activity.

V. Dutoit, V. Rubio-Godoy, P.-Y. Dietrich, A.-L. Quiqueres, V. Schnuriger, D. Rimoldi, D. Lienard, D. Speiser, P. Guillaume, P. Batard, et al. (2001)
Cancer Res. 61, 5850-5856
 |  Abstract »  |  Full Text »  |  PDF »

Combinatorial Peptide Libraries as an Alternative Approach to the Identification of Ligands for Tumor-reactive Cytolytic T Lymphocytes.

C. Pinilla, V. Rubio-Godoy, V. Dutoit, P. Guillaume, R. Simon, Y. Zhao, R. A. Houghten, J.-C. Cerottini, P. Romero, and D. Valmori (2001)
Cancer Res. 61, 5153-5160
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Expression of Cyclin-Dependent Kinase 4 Results in Epidermal Hyperplasia, Hypertrophy, and Severe Dermal Fibrosis.

P. L. Miliani de Marval, I. B. Gimenez-Conti, M. LaCava, L. A. Martinez, C. J. Conti, and M. L. Rodriguez-Puebla (2001)
Am. J. Pathol. 159, 369-379
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of the INK4a/ARF locus in polycythemia vera.

C. Dai and S. B. Krantz (2001)
Blood 97, 3424-3432
 |  Abstract »  |  Full Text »  |  PDF »

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas.

N. Bardeesy, B. C. Bastian, A. Hezel, D. Pinkel, R. A. DePinho, and L. Chin (2001)
Mol. Cell. Biol. 21, 2144-2153
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of a New Melanoma Antigen, MART-2, Containing a Mutated Epitope Recognized by Autologous Tumor-Infiltrating T Lymphocytes.

Y. Kawakami, X. Wang, T. Shofuda, H. Sumimoto, J. P. Tupesis, E. Fitzgerald, and S. A. Rosenberg (2001)
J. Immunol. 166, 2871-2877
 |  Abstract »  |  Full Text »  |  PDF »

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors.

P. D. Jeffrey, L. Tong, and N. P. Pavletich (2000)
Genes & Dev. 14, 3115-3125
 |  Abstract »  |  Full Text »

Tumor Cells Present MHC Class II-Restricted Nuclear and Mitochondrial Antigens and Are the Predominant Antigen Presenting Cells In Vivo.

L. Qi, J.-M. Rojas, and S. Ostrand-Rosenberg (2000)
J. Immunol. 165, 5451-5461
 |  Abstract »  |  Full Text »  |  PDF »

Manipulating the onset of cell cycle withdrawal in differentiated erythroid cells with cyclin-dependent kinases and inhibitors.

I. Matushansky, F. Radparvar, and A. I. Skoultchi (2000)
Blood 96, 2755-2764
 |  Abstract »  |  Full Text »  |  PDF »

Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.

S. Chaudhuri, A. Cariappa, M. Tang, D. Bell, D. A. Haber, K. J. Isselbacher, D. Finkelstein, D. Forcione, and S. Pillai (2000)
PNAS 97, 11451-11454
 |  Abstract »  |  Full Text »  |  PDF »

p16Ink4a Tumor Suppressor Function in Lung Cancer Cells Involves Cyclin-dependent Kinase 2 Inhibition by Cip/Kip Protein Redistribution.

B. Grimison, T. A. Langan, and R. A. Sclafani (2000)
Cell Growth Differ. 11, 507-515
 |  Abstract »  |  Full Text »

Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele.

S. Gnjatic, Y. Nagata, E. Jager, E. Stockert, S. Shankara, B. L. Roberts, G. P. Mazzara, S. Y. Lee, P. R. Dunbar, B. Dupont, et al. (2000)
PNAS 97, 10917-10922
 |  Abstract »  |  Full Text »  |  PDF »

Low Prevalence of Germline CDKN2A and CDK4 Mutations in Patients With Early-Onset Melanoma.

H. Tsao, X. Zhang, K. Kwitkiwski, D. M. Finkelstein, A. J. Sober, and F. G. Haluska (2000)
Arch Dermatol 136, 1118-1122
 |  Abstract »  |  Full Text »  |  PDF »

Adoptive Immunotherapy by Avidin-driven Cytotoxic T Lymphocyte- Tumor Bridging.

M. Guttinger, F. Guidi, M. Chinol, E. Reali, F. Veglia, G. Viale, G. Paganelli, A. Corti, and A. G. Siccardi (2000)
Cancer Res. 60, 4211-4215
 |  Abstract »  |  Full Text »

Identification of a New Endoplasmic Reticulum-resident Protein Recognized by HLA-A24-restricted Tumor-infiltrating Lymphocytes of Lung Cancer.

K. Kawano, S. Gomi, K. Tanaka, N. Tsuda, T. Kamura, K. Itoh, and A. Yamada (2000)
Cancer Res. 60, 3550-3558
 |  Abstract »  |  Full Text »

Genotype-Phenotype Relationships in U.S. Melanoma-Prone Families With CDKN2A and CDK4 Mutations.

A. M. Goldstein, J. P. Struewing, A. Chidambaram, M. C. Fraser, and M. A. Tucker (2000)
J Natl Cancer Inst 92, 1006-1010
 |  Abstract »  |  Full Text »  |  PDF »

High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene.

J.-F. Baurain, D. Colau, N. van Baren, C. Landry, V. Martelange, M. Vikkula, T. Boon, and P. G. Coulie (2000)
J. Immunol. 164, 6057-6066
 |  Abstract »  |  Full Text »  |  PDF »

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