Science 1 September 1995: Vol. 269. no. 5228, pp. 1267 - 1270 DOI: 10.1126/science.7544492

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Articles

Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein Stability.

Q. Zhu, H. Yasumoto, and R. Y. L. Tsai (2006)
Mol. Cell. Biol. 26, 9279-9290
 |  Abstract »  |  Full Text »  |  PDF »

Telomere Biology and Cardiovascular Disease.

J. J. Fuster and V. Andres (2006)
Circ. Res. 99, 1167-1180
 |  Abstract »  |  Full Text »  |  PDF »

Regulation and Effects of Modulation of Telomerase Reverse Transcriptase Expression in Primordial Germ Cells During Development.

M. Coussens, Y. Yamazaki, S. Moisyadi, R. Suganuma, R. Yanagimachi, and R. Allsopp (2006)
Biol Reprod 75, 785-791
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The Telomerase Activity of Adult Mouse Testis Resides in the Spermatogonial {alpha}6-Integrin-Positive Side Population Enriched in Germinal Stem Cells.

L. Riou, H. Bastos, B. Lassalle, M. Coureuil, J. Testart, F. D. Boussin, I. Allemand, and P. Fouchet (2005)
Endocrinology 146, 3926-3932
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Biography of Carol W. Greider.

R. Nuzzo (2005)
PNAS 102, 8077-8079
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Functional characterization of telomerase RNA variants found in patients with hematologic disorders.

H. Ly, R. T. Calado, P. Allard, G. M. Baerlocher, P. M. Lansdorp, N. S. Young, and T. G. Parslow (2005)
Blood 105, 2332-2339
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Transgenic Mouse Model Reveals Humanlike Regulation of an 8-kbp Human TERT Gene Promoter Fragment in Normal and Tumor Tissues.

J. M. Ritz, O. Kuhle, S. Riethdorf, B. Sipos, W. Deppert, C. Englert, and C. Gunes (2005)
Cancer Res. 65, 1187-1196
 |  Abstract »  |  Full Text »  |  PDF »

Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis.

A Sturm, A Z A Leite, S Danese, K A Krivacic, G A West, S Mohr, J W Jacobberger, and C Fiocchi (2004)
Gut 53, 1624-1631
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Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo.

Y. J. Chiang, M. T. Hemann, K. S. Hathcock, L. Tessarollo, L. Feigenbaum, W. C. Hahn, and R. J. Hodes (2004)
Mol. Cell. Biol. 24, 7024-7031
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Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.

K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
Mol. Cell. Biol. 24, 5050-5059
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity.

H. J. Kang, Y. S. Choi, S.-B. Hong, K.-W. Kim, R.-S. Woo, S. J. Won, E. J. Kim, H. K. Jeon, S.-Y. Jo, T. K. Kim, et al. (2004)
J. Neurosci. 24, 1280-1287
 |  Abstract »  |  Full Text »  |  PDF »

Development of a Cancer-Targeted Tissue-Specific Promoter System.

T. Fukazawa, Y. Maeda, F. M. Sladek, and L. B. Owen-Schaub (2004)
Cancer Res. 64, 363-369
 |  Abstract »  |  Full Text »  |  PDF »

Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans.

D. X. Mason, E. Goneska, and C. W. Greider (2003)
Mol. Cell. Biol. 23, 5606-5613
 |  Abstract »  |  Full Text »  |  PDF »

The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus.

L. Fragnet, M. A. Blasco, W. Klapper, and D. Rasschaert (2003)
J. Virol. 77, 5985-5996
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Telomere attrition and Chk2 activation in human heart failure.

H. Oh, S. C. Wang, A. Prahash, M. Sano, C. S. Moravec, G. E. Taffet, L. H. Michael, K. A. Youker, M. L. Entman, and M. D. Schneider (2003)
PNAS 100, 5378-5383
 |  Abstract »  |  Full Text »  |  PDF »

Expression of mRNAs for Telomeric Repeat Binding Factor (TRF)-1 and TRF2 in Atypical Adenomatous Hyperplasia and Adenocarcinoma of the Lung.

K. Nakanishi, T. Kawai, F. Kumaki, S. Hiroi, M. Mukai, E. Ikeda, C. E. Koering, and E. Gilson (2003)
Clin. Cancer Res. 9, 1105-1111
 |  Abstract »  |  Full Text »  |  PDF »

The Promoter of the Heterochromatic Drosophila Telomeric Retrotransposon, HeT-A, Is Active When Moved Into Euchromatic Locations.

J. A. George and M.-L. Pardue (2003)
Genetics 163, 625-635
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase Mediates the Cell Survival-Promoting Actions of Brain-Derived Neurotrophic Factor and Secreted Amyloid Precursor Protein in Developing Hippocampal Neurons.

W. Fu, C. Lu, and M. P. Mattson (2002)
J. Neurosci. 22, 10710-10719
 |  Abstract »  |  Full Text »  |  PDF »

Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro.

G. Gavory, M. Farrow, and S. Balasubramanian (2002)
Nucleic Acids Res. 30, 4470-4480
 |  Abstract »  |  Full Text »  |  PDF »

Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells.

S. Dolci, L. Levati, M. Pellegrini, I. Faraoni, G. Graziani, A. Di Carlo, and R. Geremia (2002)
J. Cell Sci. 115, 1643-1649
 |  Abstract »  |  Full Text »  |  PDF »

Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells.

E. Samper, P. Fernandez, R. Eguia, L. Martin-Rivera, A. Bernad, M. A. Blasco, and M. Aracil (2002)
Blood 99, 2767-2775
 |  Abstract »  |  Full Text »  |  PDF »

Limited Proliferation and Telomere Dysfunction following Telomerase Inhibition in Immortal Murine Fibroblasts.

J. Boklan, G. Nanjangud, K. L. MacKenzie, C. May, M. Sadelain, and M. A. S. Moore (2002)
Cancer Res. 62, 2104-2114
 |  Abstract »  |  Full Text »  |  PDF »

A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.

J.-L. Chen, K. K. Opperman, and C. W. Greider (2002)
Nucleic Acids Res. 30, 592-597
 |  Abstract »  |  Full Text »  |  PDF »

E2F-1 represses transcription of the human telomerase reverse transcriptase gene.

D. L. Crowe, D. C. Nguyen, K. J. Tsang, and S. Kyo (2001)
Nucleic Acids Res. 29, 2789-2794
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase Inhibition in RenCa, a Murine Tumor Cell Line with Short Telomeres, by Overexpression of a Dominant Negative mTERT Mutant, Reveals Fundamental Differences in Telomerase Regulation between Human and Murine Cells.

J. Sachsinger, E. Gonzalez-Suarez, E. Samper, R. Heicappell, M. Muller, and Maria. A. Blasco (2001)
Cancer Res. 61, 5580-5586
 |  Abstract »  |  Full Text »  |  PDF »

Telomere dysfunction alters the chemotherapeutic profile of transformed cells.

K.-H. Lee, K. L. Rudolph, Y.-J. Ju, R. A. Greenberg, L. Cannizzaro, L. Chin, S. R. Weiler, and R. A. DePinho (2001)
PNAS 98, 3381-3386
 |  Abstract »  |  Full Text »  |  PDF »

The Telomerase/Vault-Associated Protein Tep1 Is Required for Vault RNA Stability and Its Association with the Vault Particle.

V. A. Kickhoefer, Y. Liu, L. B. Kong, B. E. Snow, P. L. Stewart, L. Harrington, and L. H. Rome (2001)
J. Cell Biol. 152, 157-164
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Induction of Telomerase Activity in Fibroblasts from Bleomycin-Injured Lungs.

Y. Nozaki, T. Liu, K. Hatano, M. Gharaee-Kermani, and S. H. Phan (2000)
Am. J. Respir. Cell Mol. Biol. 23, 460-465
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Role of Telomerase in Normal and Cancer Cells.

M. Meyerson (2000)
J. Clin. Oncol. 18, 2626-2634
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Interference Footprinting Analysis of Telomerase Elongation Complexes.

S. Benjamin, N. Baran, and H. Manor (2000)
Mol. Cell. Biol. 20, 4224-4237
 |  Abstract »  |  Full Text »

Telomere Maintenance in Telomerase-Deficient Mouse Embryonic Stem Cells: Characterization of an Amplified Telomeric DNA.

H. Niida, Y. Shinkai, M. P. Hande, T. Matsumoto, S. Takehara, M. Tachibana, M. Oshimura, P. M. Lansdorp, and Y. Furuichi (2000)
Mol. Cell. Biol. 20, 4115-4127
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Telomerase Activity and Expression of hTRT and hTR in Gastrointestinal Stromal Tumors in Comparison with Extragastrointestinal Sarcomas.

T. Gunther, R. Schneider-Stock, C. Hackel, M. Pross, H.-U. Schulz, H. Lippert, and A. Roessner (2000)
Clin. Cancer Res. 6, 1811-1818
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Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription.

P. Finnon, A. R.J. Silver, and S. D. Bouffler (2000)
Carcinogenesis 21, 573-578
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the hTERT Gene Is Regulated at the Level of Transcriptional Initiation and Repressed by Mad1.

C. Günes, S. Lichtsteiner, A. P. Vasserot, and C. Englert (2000)
Cancer Res. 60, 2116-2121
 |  Abstract »  |  Full Text »

Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA.

S. Le, R. Sternglanz, and C. W. Greider (2000)
Mol. Biol. Cell 11, 999-1010
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Molecular Manifestations and Molecular Determinants of Telomere Capping.

E.H. BLACKBURN, S. CHAN, J. CHANG, T.B. FULTON, A. KRAUSKOPF, M. MCEACHERN, J. PRESCOTT, J. ROY, C. SMITH, and H. WANG (2000)
Cold Spring Harb Symp Quant Biol 65, 253-264
 |  Abstract »  |  PDF »

Studies of the molecular mechanisms in the regulation of telomerase activity.

J.-P. LIU (1999)
FASEB J 13, 2091-2104
 |  Abstract »  |  Full Text »

Telomeres and telomerase.

M. A. Blasco, S. M. Gasser, and J. Lingner (1999)
Genes & Dev. 13, 2353-2359
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Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro.

V. M. Tesmer, L. P. Ford, S. E. Holt, B. C. Frank, X. Yi, D. L. Aisner, M. Ouellette, J. W. Shay, and W. E. Wright (1999)
Mol. Cell. Biol. 19, 6207-6216
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening.

J. Zhu, H. Wang, J. M. Bishop, and E. H. Blackburn (1999)
PNAS 96, 3723-3728
 |  Abstract »  |  Full Text »  |  PDF »

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice.

M. P. Hande, E. Samper, P. Lansdorp, and M. A. Blasco (1999)
J. Cell Biol. 144, 589-601
 |  Abstract »  |  Full Text »  |  PDF »

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3' End.

J. R. Mitchell, J. Cheng, and K. Collins (1999)
Mol. Cell. Biol. 19, 567-576
 |  Abstract »  |  Full Text »  |  PDF »

Specific telomerase RNA residues distant from the template are essential for telomerase function.

J. Roy, T. B. Fulton, and E. H. Blackburn (1998)
Genes & Dev. 12, 3286-3300
 |  Abstract »  |  Full Text »

Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties.

E. C. Greene and D. E. Shippen (1998)
Genes & Dev. 12, 2921-2931
 |  Abstract »  |  Full Text »

Expression of mouse telomerase catalytic subunit in embryos and adult tissues.

L. Martin-Rivera, E. Herrera, J. P. Albar, and M. A. Blasco (1998)
PNAS 95, 10471-10476
 |  Abstract »  |  Full Text »  |  PDF »

Telomere length regulation in mice is linked to a novel chromosome locus.

L. Zhu, K. S. Hathcock, P. Hande, P. M. Lansdorp, M. F. Seldin, and R. J. Hodes (1998)
PNAS 95, 8648-8653
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow.

J. Yui, C.-P. Chiu, and P. M. Lansdorp (1998)
Blood 91, 3255-3262
 |  Abstract »  |  Full Text »  |  PDF »

The telomerase reverse transcriptase: components and regulation.

C. I. Nugent and V. Lundblad (1998)
Genes & Dev. 12, 1073-1085
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Organization of Chromosome Ends in Ustilago maydis. RecQ-like Helicase Motifs at Telomeric Regions.

P. Sanchez-Alonso and P. Guzman (1998)
Genetics 148, 1043-1054
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase activity, cell proliferation, and cancer.

C. W. Greider (1998)
PNAS 95, 90-92
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Human telomerase contains evolutionarily conserved catalytic and structural subunits.

L. Harrington, W. Zhou, T. McPhail, R. Oulton, D. S.K. Yeung, V. Mar, M. B. Bass, and M. O. Robinson (1997)
Genes & Dev. 11, 3109-3115
 |  Abstract »  |  Full Text »  |  PDF »

Functionally interacting telomerase RNAs in the yeast telomerase complex.

J. Prescott and E. H. Blackburn (1997)
Genes & Dev. 11, 2790-2800
 |  Abstract »  |  Full Text »  |  PDF »

Normal human chromosomes have long G-rich telomeric overhangs at one end.

W. E. Wright, V. M. Tesmer, K. E. Huffman, S. D. Levene, and J. W. Shay (1997)
Genes & Dev. 11, 2801-2809
 |  Abstract »  |  Full Text »  |  PDF »

Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.

J. Lingner, T. R. Cech, T. R. Hughes, and V. Lundblad (1997)
PNAS 94, 11190-11195
 |  Abstract »  |  Full Text »  |  PDF »

Reflections on Telomeres, Growth, Aging, and Essential Hypertension.

A. Aviv and H. Aviv (1997)
Hypertension 29, 1067-1072
 |  Abstract »  |  Full Text »

A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains.

A. Bhattacharyya and E. H. Blackburn (1997)
PNAS 94, 2823-2827
 |  Abstract »  |  Full Text »  |  PDF »

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro..

J Prescott and E H Blackburn (1997)
Genes & Dev. 11, 528-540
 |  Abstract »  |  PDF »

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase..

M J McEachern and E H Blackburn (1996)
Genes & Dev. 10, 1822-1834
 |  Abstract »  |  PDF »

Telomeres: Beginning to Understand the End.

V. A. Zakian (1995)
Science 270, 1601-1607
 |  Abstract »  |  PDF »

Mechanisms of Toxicity and Carcinogenesis.

B. F. Trump (1995)
Toxicol Pathol 23, 775-827
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Telomerase and DNA end replication: no longer a lagging strand problem?.

J Lingner, J. Cooper, and T. Cech (1995)
Science 269, 1533-1534
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The RNA component of human telomerase.

J Feng, W. Funk, S. Wang, S. Weinrich, A. Avilion, C. Chiu, R. Adams, E Chang, R. Allsopp, J Yu, et al. (1995)
Science 269, 1236-1241
 |  Abstract »  |  PDF »

Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using an in Vivo Reconstitution System.

L. Martin-Rivera and M. A. Blasco (2001)
J. Biol. Chem. 276, 5856-5865
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism for the Reduction of Telomerase Expression during Muscle Cell Differentiation.

K. Nozawa, K. Maehara, and K.-i. Isobe (2001)
J. Biol. Chem. 276, 22016-22023
 |  Abstract »  |  Full Text »  |  PDF »

The Latency-associated Nuclear Antigen of Kaposi's Sarcoma-associated Herpesvirus Transactivates the Telomerase Reverse Transcriptase Promoter.

J. S. Knight, M. A. Cotter II, and E. S. Robertson (2001)
J. Biol. Chem. 276, 22971-22978
 |  Abstract »  |  Full Text »  |  PDF »

Tetrahymena proteins p80 and p95 are not core telomerase components.

D. X. Mason, C. Autexier, and C. W. Greider (2001)
PNAS 98, 12368-12373
 |  Abstract »  |  Full Text »  |  PDF »

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