Science 25 August 1995: Vol. 269. no. 5227, pp. 1102 - 1105 DOI: 10.1126/science.7652556

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Articles

A Dictyostelium homologue of the metazoan Cbl proteins regulates STAT signalling.

J. Langenick, T. Araki, Y. Yamada, and J. G. Williams (2008)
J. Cell Sci. 121, 3524-3530
 |  Abstract »  |  Full Text »  |  PDF »

A Tale of Two Cbls: Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation.

S. Pennock and Z. Wang (2008)
Mol. Cell. Biol. 28, 3020-3037
 |  Abstract »  |  Full Text »  |  PDF »

Partners in AML: Flt3 and c-Cbl.

W. Y. Langdon (2007)
Blood 110, 793-794
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An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development.

K. Modzelewska, M. G. Elgort, J. Huang, G. Jongeward, A. Lauritzen, C. H. Yoon, P. W. Sternberg, and N. Moghal (2007)
Mol. Cell. Biol. 27, 3695-3707
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A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLC{gamma}1 activation and angiogenesis.

A. J. Singh, R. D. Meyer, G. Navruzbekov, R. Shelke, L. Duan, H. Band, S. E. Leeman, and N. Rahimi (2007)
PNAS 104, 5413-5418
 |  Abstract »  |  Full Text »  |  PDF »

sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans.

B. P. Gupta, J. Liu, B. J. Hwang, N. Moghal, and P. W. Sternberg (2006)
Genetics 174, 1315-1326
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Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development.

C. B. Walser, G. Battu, E. F. Hoier, and A. Hajnal (2006)
Development 133, 3461-3471
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Identification and Classification of Genes That Act Antagonistically to let-60 Ras Signaling in Caenorhabditis elegans Vulval Development.

C. J. Ceol, F. Stegmeier, M. M. Harrison, and H. R. Horvitz (2006)
Genetics 173, 709-726
 |  Abstract »  |  Full Text »  |  PDF »

The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.

T. A. Berset, E. F. Hoier, and A. Hajnal (2005)
Genes & Dev. 19, 1328-1340
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Ubiquitin Ligase Activity of c-Cbl Guides the Epidermal Growth Factor Receptor into Clathrin-coated Pits by Two Distinct Modes of Eps15 Recruitment.

A. A. de Melker, G. van der Horst, and J. Borst (2004)
J. Biol. Chem. 279, 55465-55473
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c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15.

A. A. de Melker, G. van der Horst, and J. Borst (2004)
J. Cell Sci. 117, 5001-5012
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Basis for the Requirement of Kinase Activity for Cbl-dependent Ubiquitinylation and Degradation of a Target Tyrosine Kinase.

A. K. Ghosh, A. L. Reddi, N. L. Rao, L. Duan, V. Band, and H. Band (2004)
J. Biol. Chem. 279, 36132-36141
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Ubiquitin Protein Ligase Activity in c-Cbl by Phosphorylation-induced Conformational Change and Constitutive Activation by Tyrosine to Glutamate Point Mutations.

C. K. Kassenbrock and S. M. Anderson (2004)
J. Biol. Chem. 279, 28017-28027
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines.

E. Wandzioch, C. E. Edling, R. H. Palmer, L. Carlsson, and B. Hallberg (2004)
Blood 104, 51-57
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-3-Deficient Mice Exhibit Normal Epithelial Development.

E. K. Griffiths, O. Sanchez, P. Mill, C. Krawczyk, C. V. Hojilla, E. Rubin, M. M. Nau, R. Khokha, S. Lipkowitz, C.-c. Hui, et al. (2003)
Mol. Cell. Biol. 23, 7708-7718
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein G{alpha}q and excitable cells in C. elegans.

N. Moghal, L. R. Garcia, L. A. Khan, K. Iwasaki, and P. W. Sternberg (2003)
Development 130, 4553-4566
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Endothelial Growth Factor-dependent Down-regulation of Flk-1/KDR Involves Cbl-mediated Ubiquitination: CONSEQUENCES ON NITRIC OXIDE PRODUCTION FROM ENDOTHELIAL CELLS.

M. Duval, S. Bedard-Goulet, C. Delisle, and J.-P. Gratton (2003)
J. Biol. Chem. 278, 20091-20097
 |  Abstract »  |  Full Text »  |  PDF »

A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase.

C. B.F. Thien, R. M. Scaife, J. M. Papadimitriou, M. A. Murphy, D. D.L. Bowtell, and W. Y. Langdon (2003)
J. Exp. Med. 197, 503-513
 |  Abstract »  |  Full Text »  |  PDF »

The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.

R. M. Scaife, S. A. Courtneidge, and W. Y. Langdon (2003)
J. Cell Sci. 116, 463-473
 |  Abstract »  |  Full Text »  |  PDF »

A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans.

N. Moghal and P. W. Sternberg (2003)
Development 130, 57-69
 |  Abstract »  |  Full Text »  |  PDF »

Interaction between Two Ubiquitin-Protein Isopeptide Ligases of Different Classes, CBLC and AIP4/ITCH.

J.-R. Courbard, F. Fiore, J. Adelaide, J.-P. Borg, D. Birnbaum, and V. Ollendorff (2002)
J. Biol. Chem. 277, 45267-45275
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl-Dependent EphA2 Protein Degradation Is Induced by Ligand Binding.

J. Walker-Daniels, D. J. Riese II, and M. S. Kinch (2002)
Mol. Cancer Res. 1, 79-87
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination.

T. E. I. Taher, E. P. M. Tjin, E. A. Beuling, J. Borst, M. Spaargaren, and S. T. Pals (2002)
J. Immunol. 169, 3793-3800
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is a Negative Regulator of GH-Stimulated STAT5-Mediated Transcription.

E. L. K. Goh, T. Zhu, W.-Y. Leong, and P. E. Lobie (2002)
Endocrinology 143, 3590-3603
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Src Family Kinases Blocks Epidermal Growth Factor (EGF)-induced Activation of Akt, Phosphorylation of c-Cbl, and Ubiquitination of the EGF Receptor.

C. K. Kassenbrock, S. Hunter, P. Garl, G. L. Johnson, and S. M. Anderson (2002)
J. Biol. Chem. 277, 24967-24975
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When cell biology meets development: endocytic regulation of signaling pathways.

E. S. Seto, H. J. Bellen, and T. E. Lloyd (2002)
Genes & Dev. 16, 1314-1336
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New perspectives in PDGF receptor downregulation: the main role of phosphotyrosine phosphatases.

P. Chiarugi, P. Cirri, M. L. Taddei, D. Talini, L. Doria, T. Fiaschi, F. Buricchi, E. Giannoni, G. Camici, G. Raugei, et al. (2002)
J. Cell Sci. 115, 2219-2232
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FRS2alpha attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl.

A. Wong, B. Lamothe, A. Lee, J. Schlessinger, and I. Lax (2002)
PNAS 99, 6684-6689
 |  Abstract »  |  Full Text »  |  PDF »

The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system.

N. Rao, I. Dodge, and H. Band (2002)
J. Leukoc. Biol. 71, 753-763
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages.

A. Kallies, F. Rosenbauer, M. Scheller, K.-P. Knobeloch, and I. Horak (2002)
Blood 99, 3213-3219
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Development and T Cell Responses in Mice with Mutations Affecting Tyrosines 292 or 315 of the Zap-70 Protein Tyrosine Kinase.

A. Magnan, V. Di Bartolo, A.-M. Mura, C. Boyer, M. Richelme, Y.-L. Lin, A. Roure, A. Gillet, C. Arrieumerlou, O. Acuto, et al. (2001)
J. Exp. Med. 194, 491-506
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The interface of receptor trafficking and signalling.

M. J. Clague and S. Urbe (2001)
J. Cell Sci. 114, 3075-3081
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c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.

A. A. de Melker, G. van der Horst, J. Calafat, H. Jansen, and J. Borst (2001)
J. Cell Sci. 114, 2167-2178
 |  Abstract »  |  Full Text »  |  PDF »

Requirements of Multiple Domains of SLI-1, a Caenorhabditis elegans Homologue of c-Cbl, and an Inhibitory Tyrosine in LET-23 in Regulating Vulval Differentiation.

C. H. Yoon, C. Chang, N. A. Hopper, G. M. Lesa, and P. W. Sternberg (2000)
Mol. Biol. Cell 11, 4019-4031
 |  Abstract »  |  Full Text »

New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway.

H. Gu, H. Maeda, J. J. Moon, J. D. Lord, M. Yoakim, B. H. Nelson, and B. G. Neel (2000)
Mol. Cell. Biol. 20, 7109-7120
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-transforming Variants Trigger a Cascade of Molecular Alterations That Lead to Epithelial Mesenchymal Conversion.

T. M. Fournier, L. Lamorte, C. R. Maroun, M. Lupher, H. Band, W. Langdon, and M. Park (2000)
Mol. Biol. Cell 11, 3397-3410
 |  Abstract »  |  Full Text »

Distinct and Redundant Functions of {micro}1 Medium Chains of the AP-1 Clathrin-Associated Protein Complex in the Nematode Caenorhabditis elegans.

J. Shim, P. W. Sternberg, and J. Lee (2000)
Mol. Biol. Cell 11, 2743-2756
 |  Abstract »  |  Full Text »

The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells.

N. Rao, M. L. Lupher Jr., S. Ota, K. A. Reedquist, B. J. Druker, and H. Band (2000)
J. Immunol. 164, 4616-4626
 |  Abstract »  |  Full Text »  |  PDF »

Src Family Kinases Negatively Regulate Platelet-derived Growth Factor alpha Receptor-dependent Signaling and Disease Progression.

S. Rosenkranz, Y. Ikuno, F. L. Leong, R. A. Klinghoffer, S. Miyake, H. Band, and A. Kazlauskas (2000)
J. Biol. Chem. 275, 9620-9627
 |  Abstract »  |  Full Text »  |  PDF »

Cbl Suppresses B Cell Receptor-Mediated Phospholipase C (Plc)-{gamma}2 Activation by Regulating B Cell Linker Protein-Plc-{gamma}2 Binding.

T. Yasuda, A. Maeda, M. Kurosaki, T. Tezuka, K. Hironaka, T. Yamamoto, and T. Kurosaki (2000)
J. Exp. Med. 191, 641-650
 |  Abstract »  |  Full Text »  |  PDF »

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation.

C. E. Andoniou, N. L. Lill, C. B. Thien, M. L. Lupher Jr., S. Ota, D. D. L. Bowtell, R. M. Scaife, W. Y. Langdon, and H. Band (2000)
Mol. Cell. Biol. 20, 851-867
 |  Abstract »  |  Full Text »  |  PDF »

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor.

N. L. Lill, P. Douillard, R. A. Awwad, S. Ota, M. L. Lupher Jr., S. Miyake, N. Meissner-Lula, V. W. Hsu, and H. Band (2000)
J. Biol. Chem. 275, 367-377
 |  Abstract »  |  Full Text »  |  PDF »

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase.

S. Ota, K. Hazeki, N. Rao, M. L. Lupher Jr., C. E. Andoniou, B. Druker, and H. Band (2000)
J. Biol. Chem. 275, 414-422
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology.

R. Scaife and W. Langdon (2000)
J. Cell Sci. 113, 215-226
 |  Abstract »  |  PDF »

The Adapter Protein Crkl Links Cbl to C3G after Integrin Ligation and Enhances Cell Migration.

N. Uemura and J. D. Griffin (1999)
J. Biol. Chem. 274, 37525-37532
 |  Abstract »  |  Full Text »  |  PDF »

High Affinity IgG Receptor Activation of Src Family Kinases Is Required for Modulation of the Shc-Grb2-Sos Complex and the Downstream Activation of the Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase.

R.-K. Park, A. Erdreich-Epstein, M. Liu, K. D. Izadi, and D. L. Durden (1999)
J. Immunol. 163, 6023-6034
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of Fc{gamma} Receptor-Mediated Phagocytosis by Transforming Mutants of Cbl.

N. Sato, M.-K. Kim, and A. D. Schreiber (1999)
J. Immunol. 163, 6123-6131
 |  Abstract »  |  Full Text »  |  PDF »

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7.

M. Yokouchi, T. Kondo, A. Houghton, M. Bartkiewicz, W. C. Horne, H. Zhang, A. Yoshimura, and R. Baron (1999)
J. Biol. Chem. 274, 31707-31712
 |  Abstract »  |  Full Text »  |  PDF »

Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl. A ROLE IN c-Cbl's TYROSINE PHOSPHORYLATION AND ITS ASSOCIATION WITH EPIDERMAL GROWTH FACTOR RECEPTOR.

M. Bartkiewicz, A. Houghton, and R. Baron (1999)
J. Biol. Chem. 274, 30887-30895
 |  Abstract »  |  Full Text »  |  PDF »

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase.

C. A. Joazeiro, S. S. Wing, H. Huang, J. D. Leverson, T. Hunter, and Y. Liu (1999)
Science 286, 309-312
 |  Abstract »  |  Full Text »

The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells.

J. E. M. van Leeuwen, P. K. Paik, and L. E. Samelson (1999)
Mol. Cell. Biol. 19, 6652-6664
 |  Abstract »  |  Full Text »  |  PDF »

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor.

H. Waterman, G. Levkowitz, I. Alroy, and Y. Yarden (1999)
J. Biol. Chem. 274, 22151-22154
 |  Abstract »  |  Full Text »  |  PDF »

Role of Protein Kinase C in Signal Attenuation following T Cell Receptor Engagement.

B. Fernandez, M. P. Czech, and H. Meisner (1999)
J. Biol. Chem. 274, 20244-20250
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase C Activation Inhibits Tyrosine Phosphorylation of Cbl and Its Recruitment of Src Homology 2 Domain-Containing Proteins.

Y. Liu, Y.-C. Liu, N. Meller, L. Giampa, C. Elly, M. Doyle, and A. Altman (1999)
J. Immunol. 162, 7095-7101
 |  Abstract »  |  Full Text »  |  PDF »

Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes.

C. B. F. Thien, D. D. L. Bowtell, and W. Y. Langdon (1999)
J. Immunol. 162, 7133-7139
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation. A CRITICAL ROLE FOR Cbl TYROSINE KINASE-BINDING DOMAIN.

S. Miyake, K. P. Mullane-Robinson, N. L. Lill, P. Douillard, and H. Band (1999)
J. Biol. Chem. 274, 16619-16628
 |  Abstract »  |  Full Text »  |  PDF »

Dual Regulation of T Cell Receptor-mediated Signaling by Oncogenic Cbl Mutant 70Z.

Z. Zhang, C. Elly, A. Altman, and Y.-C. Liu (1999)
J. Biol. Chem. 274, 4883-4889
 |  Abstract »  |  Full Text »  |  PDF »

The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling.

M. F. Denny, H. C. Kaufman, A. C. Chan, and D. B. Straus (1999)
J. Biol. Chem. 274, 5146-5152
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Nuclear Factor of Activated T Cells-(NFAT) and Activating Protein 1 (AP-1) by Oncogenic 70Z Cbl Requires an Intact Phosphotyrosine Binding Domain but Not Crk(L) or p85 Phosphatidylinositol 3-Kinase Association.

J. E. M. van Leeuwen, P. K. Paik, and L. E. Samelson (1999)
J. Biol. Chem. 274, 5153-5162
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase. A CRITICAL ROLE FOR Cbl PHOSPHOTYROSINE-BINDING DOMAIN BINDING TO Syk PHOSPHOTYROSINE 323.

M. L. Lupher Jr., N. Rao, N. L. Lill, C. E. Andoniou, S. Miyake, E. A. Clark, B. Druker, and H. Band (1998)
J. Biol. Chem. 273, 35273-35281
 |  Abstract »  |  Full Text »  |  PDF »

Altered thymic positive selection and intracellular signals in Cbl-deficient mice.

M. Naramura, H. K. Kole, R.-J. Hu, and H. Gu (1998)
PNAS 95, 15547-15552
 |  Abstract »  |  Full Text »  |  PDF »

DAP12-mediated Signal Transduction in Natural Killer Cells. A DOMINANT ROLE FOR THE Syk PROTEIN-TYROSINE KINASE.

D. W. McVicar, L. S. Taylor, P. Gosselin, J. Willette-Brown, A. I. Mikhael, R. L. Geahlen, M. C. Nakamura, P. Linnemeyer, W. E. Seaman, S. K. Anderson, et al. (1998)
J. Biol. Chem. 273, 32934-32942
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.

G. Levkowitz, H. Waterman, E. Zamir, Z. Kam, S. Oved, W. Y. Langdon, L. Beguinot, B. Geiger, and Y. Yarden (1998)
Genes & Dev. 12, 3663-3674
 |  Abstract »  |  Full Text »

SLP-76-Cbl-Grb2-Shc Interactions in Fcgamma RI Signaling.

J. Chu, Y. Liu, G. A. Koretzky, and D. L. Durden (1998)
Blood 92, 1697-1706
 |  Abstract »  |  Full Text »  |  PDF »

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice.

M. A. Murphy, R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello, C. B. F. Thien, W. Y. Langdon, and D. D. L. Bowtell (1998)
Mol. Cell. Biol. 18, 4872-4882
 |  Abstract »  |  Full Text »  |  PDF »

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.

S. Miyake, M. L. Lupher Jr., B. Druker, and H. Band (1998)
PNAS 95, 7927-7932
 |  Abstract »  |  Full Text »  |  PDF »

The CBL-related Protein CBLB Participates in FLT3 and Interleukin-7 Receptor Signal Transduction in Pro-B Cells.

C. Lavagna-Sevenier, S. Marchetto, D. Birnbaum, and O. Rosnet (1998)
J. Biol. Chem. 273, 14962-14967
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency.

H. Waterman, I. Sabanai, B. Geiger, and Y. Yarden (1998)
J. Biol. Chem. 273, 13819-13827
 |  Abstract »  |  Full Text »  |  PDF »

CBL-GRB2 Interaction in Myeloid Immunoreceptor Tyrosine Activation Motif Signaling.

R. K. Park, W. T. Kyono, Y. Liu, and D. L. Durden (1998)
J. Immunol. 160, 5018-5027
 |  Abstract »  |  Full Text »  |  PDF »

Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases.

M. Deckert, C. Elly, A. Altman, and Y.-C. Liu (1998)
J. Biol. Chem. 273, 8867-8874
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3'-Kinase Pathway.

H. Ueno, K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai (1998)
Blood 91, 46-53
 |  Abstract »  |  Full Text »  |  PDF »

The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292 Negative Regulatory Phosphorylation Site of ZAP-70.

M. L. Lupher Jr., Z. Songyang, S. E. Shoelson, L. C. Cantley, and H. Band (1997)
J. Biol. Chem. 272, 33140-33144
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-mediated Regulation of T Cell Receptor-induced AP1 Activation. IMPLICATIONS FOR ACTIVATION VIA THE Ras SIGNALING PATHWAY.

B. L. Rellahan, L. J. Graham, B. Stoica, K. E. DeBell, and E. Bonvini (1997)
J. Biol. Chem. 272, 30806-30811
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.

A. Hajnal, C. W. Whitfield, and S. K. Kim (1997)
Genes & Dev. 11, 2715-2728
 |  Abstract »  |  Full Text »  |  PDF »

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1.

V. A. Boussiotis, G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler (1997)
Science 278, 124-128
 |  Abstract »  |  Full Text »

Impaired Plasma Membrane Targeting of Grb2-Murine Son of Sevenless (mSOS) Complex and Differential Activation of the Fyn-T Cell Receptor (TCR)-{zeta}-Cbl Pathway Mediate T Cell Hyporesponsiveness in Autoimmune Nonobese Diabetic Mice.

K. Salojin, J. Zhang, M. Cameron, B. Gill, G. Arreaza, A. Ochi, and T. L. Delovitch (1997)
J. Exp. Med. 186, 887-897
 |  Abstract »  |  Full Text »  |  PDF »

Differential Signaling after beta 1 Integrin Ligation Is Mediated Through Binding of CRKL to p120CBL and p110HEF1.

M. Sattler, R. Salgia, G. Shrikhande, S. Verma, N. Uemura, S. F. Law, E. A. Golemis, and J. D. Griffin (1997)
J. Biol. Chem. 272, 14320-14326
 |  Abstract »  |  Full Text »  |  PDF »

Steel Factor Induces Tyrosine Phosphorylation of CRKL and Binding of CRKL to a Complex Containing c-Kit, Phosphatidylinositol 3-Kinase, and p120CBL.

M. Sattler, R. Salgia, G. Shrikhande, S. Verma, E. Pisick, K. V.S. Prasad, and J. D. Griffin (1997)
J. Biol. Chem. 272, 10248-10253
 |  Abstract »  |  Full Text »  |  PDF »

Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling.

H. Ueno, K. Sasaki, K. Miyagawa, H. Honda, K. Mitani, Y. Yazaki, and H. Hirai (1997)
J. Biol. Chem. 272, 8739-8743
 |  Abstract »  |  Full Text »  |  PDF »

egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans.

R. D. Burdine, E. B. Chen, S. F. Kwok, and M. J. Stern (1997)
PNAS 94, 2433-2437
 |  Abstract »  |  Full Text »  |  PDF »

Ras-dependent, Ca2+-stimulated Activation of Nuclear Factor of Activated T Cells by a Constitutively Active Cbl Mutant in T Cells.

Y.-C. Liu, C. Elly, W. Y. Langdon, and A. Altman (1997)
J. Biol. Chem. 272, 168-173
 |  Abstract »  |  Full Text »  |  PDF »

rZIP, a RING-leucine zipper protein that regulates cell fate determination during Dictyostelium development.

P Balint-Kurti, G Ginsburg, O Rivero-Lezcano, and A. Kimmel (1997)
Development 124, 1203-1213
 |  Abstract »  |  PDF »

Regulation of the Association of p120cbl with Grb2 in Jurkat T Cells.

JeraldA. Donovan, Y. Ota, WallaceY. Langdon, and LawrenceE. Samelson (1996)
J. Biol. Chem. 271, 26369-26374
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells.

M. L. Lupher Jr., K. A. Reedquist, S. Miyake, W. Y. Langdon, and H. Band (1996)
J. Biol. Chem. 271, 24063-24068
 |  Abstract »  |  Full Text »  |  PDF »

Formation of c-Cbl·Phosphatidylinositol 3-Kinase Complexes on Lymphocyte Membranes by a p56lck-independent Mechanism.

D. Hartley and S. Corvera (1996)
J. Biol. Chem. 271, 21939-21943
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins.

T. Fukazawa, S. Miyake, V. Band, and H. Band (1996)
J. Biol. Chem. 271, 14554-14559
 |  Abstract »  |  Full Text »  |  PDF »

Activation-modulated Association of 14-3-3Proteins with Cbl in T Cells.

Y.-C. Liu, C. Elly, H. Yoshida, N. Bonnefoy-Berard, and A. Altman (1996)
J. Biol. Chem. 271, 14591-14595
 |  Abstract »  |  Full Text »  |  PDF »

Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors.

L. Smit, G. van der Horst, and J. Borst (1996)
J. Biol. Chem. 271, 8564-8569
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages.

Y. Wang, Y.-G. Yeung, W. Y. Langdon, and E. R. Stanley (1996)
J. Biol. Chem. 271, 17-20
 |  Abstract »  |  Full Text »  |  PDF »

c-Cbl Is a Suppressor of the Neu Oncogene.

G. Levkowitz, S. Oved, L. N. Klapper, D. Harari, S. Lavi, M. Sela, and Y. Yarden (2000)
J. Biol. Chem. 275, 35532-35539
 |  Abstract »  |  Full Text »  |  PDF »

Abl Family Kinases and Cbl Cooperate with the Nck Adaptor to Modulate Xenopus Development.

C. E. Adler, T. Miyoshi-Akiyama, L. M. Aleman, M. Tanaka, J. M. Smith, and B. J. Mayer (2000)
J. Biol. Chem. 275, 36472-36478
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for Direct Interaction between Sprouty and Cbl.

E. S. M. Wong, J. Lim, B. C. Low, Q. Chen, and G. R. Guy (2001)
J. Biol. Chem. 276, 5866-5875
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex.

S. A. Ettenberg, A. Magnifico, M. Cuello, M. M. Nau, Y. R. Rubinstein, Y. Yarden, A. M. Weissman, and S. Lipkowitz (2001)
J. Biol. Chem. 276, 27677-27684
 |  Abstract »  |  Full Text »  |  PDF »

The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation.

T. Shishido, T. Akagi, T. Ouchi, M.-M. Georgescu, W. Y. Langdon, and H. Hanafusa (2000)
PNAS 97, 6439-6444
 |  Abstract »  |  Full Text »  |  PDF »

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