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Science 28 July 1995:
Vol. 269. no. 5223, pp. 554 - 558
DOI: 10.1126/science.7624781

Articles

Science, Vol 269, Issue 5223, 554-558
Copyright © 1995 by American Association for the Advancement of Science


articles

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor

T Maeda, M Takekawa, and H Saito

Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

The role of mitogen-activated protein (MAP) kinase cascades in integrating distinct upstream signals was studied in yeast. Mutants that were not able to activate PBS2 MAP kinase kinase (MAPKK; Pbs2p) at high osmolarity were characterized. Pbs2p was activated by two independent signals that emanated from distinct cell-surface osmosensors. Pbs2p was activated by MAP kinase kinase kinases (MAPKKKs) Ssk2p and Ssk22p that are under the control of the SLN1-SSK1 two-component osmosensor. Alternatively, Pbs2p was activated by a mechanism that involves the binding of its amino terminal proline-rich motif to the Src homology 3 (SH3) domain of a putative transmembrane osmosensor Sho1p.


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   Abstract »    Full Text »
Independent Signaling Pathways Regulate Cellular Turgor during Hyperosmotic Stress and Appressorium-Mediated Plant Infection by Magnaporthe grisea.
K. P. Dixon, J.-R. Xu, N. Smirnoff, and N. J. Talbot (1999)
PLANT CELL 11, 2045-2058
   Abstract »    Full Text »
A Transmembrane Hybrid-Type Histidine Kinase in Arabidopsis Functions as an Osmosensor.
T. Urao, B. Yakubov, R. Satoh, K. Yamaguchi-Shinozaki, M. Seki, T. Hirayama, and K. Shinozaki (1999)
PLANT CELL 11, 1743-1754
   Abstract »    Full Text »
Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p.
M. Rep, V. Reiser, U. Gartner, J. M. Thevelein, S. Hohmann, G. Ammerer, and H. Ruis (1999)
Mol. Cell. Biol. 19, 5474-5485
   Abstract »    Full Text »    PDF »
SDF-2 Induction of Terminal Differentiation in Dictyostelium discoideum Is Mediated by the Membrane-Spanning Sensor Kinase DhkA.
N. Wang, F. Soderbom, C. Anjard, G. Shaulsky, and W. F. Loomis (1999)
Mol. Cell. Biol. 19, 4750-4756
   Abstract »    Full Text »    PDF »
Functional Characterization of the Interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.
C. Wu, E. Leberer, D. Y. Thomas, and M. Whiteway (1999)
Mol. Biol. Cell 10, 2425-2440
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Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans.
R. Alonso-Monge, F. Navarro-Garcia, G. Molero, R. Diez-Orejas, M. Gustin, J. Pla, M. Sanchez, and C. Nombela (1999)
J. Bacteriol. 181, 3058-3068
   Abstract »    Full Text »    PDF »
Caffeine-Mediated Override of Checkpoint Controls: A Requirement for rhp6 (Schizosaccharomyces pombe).
R. Rowley and J. Zhang (1999)
Genetics 152, 61-71
   Abstract »    Full Text »
Kinase Activity-dependent Nuclear Export Opposes Stress-induced Nuclear Accumulation and Retention of Hog1 Mitogen-activated Protein Kinase in the Budding Yeast Saccharomyces cerevisiae.
V. Reiser, H. Ruis, and G. Ammerer (1999)
Mol. Biol. Cell 10, 1147-1161
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An Arabidopsis GSK3/shaggy-Like Gene That Complements Yeast Salt Stress-Sensitive Mutants Is Induced by NaCl and Abscisic Acid.
H. L. Piao, K. Tae Pih, J. Hwa Lim, S. Gene Kang, J. Bo Jin, S. Hee Kim, and I. Hwang (1999)
Plant Physiology 119, 1527-1534
   Abstract »    Full Text »
Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron.
A. C. Hart, J. Kass, J. E. Shapiro, and J. M. Kaplan (1999)
J. Neurosci. 19, 1952-1958
   Abstract »    Full Text »    PDF »
Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity.
H. Miyakawa, S. K. Woo, S. C. Dahl, J. S. Handler, and H. M. Kwon (1999)
PNAS 96, 2538-2542
   Abstract »    Full Text »    PDF »



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