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Science 28 July 1995: Vol. 269. no. 5223, pp. 554 - 558 DOI: 10.1126/science.7624781
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Articles
Science, Vol 269, Issue 5223, 554-558
Copyright © 1995 by American Association for the Advancement of Science
Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
T Maeda,
M Takekawa,
and
H Saito
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
The role of mitogen-activated protein (MAP) kinase cascades in integrating distinct upstream signals was studied in yeast. Mutants that were not able to activate PBS2 MAP kinase kinase (MAPKK; Pbs2p) at high osmolarity were characterized. Pbs2p was activated by two independent signals that emanated from distinct cell-surface osmosensors. Pbs2p was activated by MAP kinase kinase kinases (MAPKKKs) Ssk2p and Ssk22p that are under the control of the SLN1-SSK1 two-component osmosensor. Alternatively, Pbs2p was activated by a mechanism that involves the binding of its amino terminal proline-rich motif to the Src homology 3 (SH3) domain of a putative transmembrane osmosensor Sho1p.
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- The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock. Hot1p AND Msn2p/Msn4p ARE REQUIRED FOR THE INDUCTION OF SUBSETS OF HIGH OSMOLARITY GLYCEROL PATHWAY-DEPENDENT GENES.
- M. Rep, M. Krantz, J. M. Thevelein, and S. Hohmann (2000)
J. Biol. Chem.
275, 8290-8300
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- Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin.
- H. Liu, H. Nishitoh, H. Ichijo, and J. M. Kyriakis (2000)
Mol. Cell. Biol.
20, 2198-2208
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- A Role for Myosin-I in Actin Assembly through Interactions with Vrp1p, Bee1p, and the Arp2/3 Complex.
- M. Evangelista, B. M. Klebl, A. H.Y. Tong, B. A. Webb, T. Leeuw, E. Leberer, M. Whiteway, D. Y. Thomas, and C. Boone (2000)
J. Cell Biol.
148, 353-362
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- Genetic Analysis of Salt-Tolerant Mutants in Arabidopsis thaliana.
- V. Quesada, M. R. Ponce, and J. L. Micol (2000)
Genetics
154, 421-436
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- PI3K signaling in the murine kidney inner medullary cell response to urea.
- Z. Zhang, X.-Y. Yang, S. P. Soltoff, and D. M. Cohen (2000)
Am J Physiol Renal Physiol
278, F155-F164
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- Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants.
- K. D. Davenport, K. E. Williams, B. D. Ullmann, and M. C. Gustin (1999)
Genetics
153, 1091-1103
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- Independent Signaling Pathways Regulate Cellular Turgor during Hyperosmotic Stress and Appressorium-Mediated Plant Infection by Magnaporthe grisea.
- K. P. Dixon, J.-R. Xu, N. Smirnoff, and N. J. Talbot (1999)
PLANT CELL
11, 2045-2058
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- A Transmembrane Hybrid-Type Histidine Kinase in Arabidopsis Functions as an Osmosensor.
- T. Urao, B. Yakubov, R. Satoh, K. Yamaguchi-Shinozaki, M. Seki, T. Hirayama, and K. Shinozaki (1999)
PLANT CELL
11, 1743-1754
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- Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p.
- M. Rep, V. Reiser, U. Gartner, J. M. Thevelein, S. Hohmann, G. Ammerer, and H. Ruis (1999)
Mol. Cell. Biol.
19, 5474-5485
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- SDF-2 Induction of Terminal Differentiation in Dictyostelium discoideum Is Mediated by the Membrane-Spanning Sensor Kinase DhkA.
- N. Wang, F. Soderbom, C. Anjard, G. Shaulsky, and W. F. Loomis (1999)
Mol. Cell. Biol.
19, 4750-4756
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- Functional Characterization of the Interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.
- C. Wu, E. Leberer, D. Y. Thomas, and M. Whiteway (1999)
Mol. Biol. Cell
10, 2425-2440
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- Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans.
- R. Alonso-Monge, F. Navarro-Garcia, G. Molero, R. Diez-Orejas, M. Gustin, J. Pla, M. Sanchez, and C. Nombela (1999)
J. Bacteriol.
181, 3058-3068
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- Caffeine-Mediated Override of Checkpoint Controls: A Requirement for rhp6 (Schizosaccharomyces pombe).
- R. Rowley and J. Zhang (1999)
Genetics
152, 61-71
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- Kinase Activity-dependent Nuclear Export Opposes Stress-induced Nuclear Accumulation and Retention of Hog1 Mitogen-activated Protein Kinase in the Budding Yeast Saccharomyces cerevisiae.
- V. Reiser, H. Ruis, and G. Ammerer (1999)
Mol. Biol. Cell
10, 1147-1161
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- An Arabidopsis GSK3/shaggy-Like Gene That Complements Yeast Salt Stress-Sensitive Mutants Is Induced by NaCl and Abscisic Acid.
- H. L. Piao, K. Tae Pih, J. Hwa Lim, S. Gene Kang, J. Bo Jin, S. Hee Kim, and I. Hwang (1999)
Plant Physiology
119, 1527-1534
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- Distinct Signaling Pathways Mediate Touch and Osmosensory Responses in a Polymodal Sensory Neuron.
- A. C. Hart, J. Kass, J. E. Shapiro, and J. M. Kaplan (1999)
J. Neurosci.
19, 1952-1958
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- Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity.
- H. Miyakawa, S. K. Woo, S. C. Dahl, J. S. Handler, and H. M. Kwon (1999)
PNAS
96, 2538-2542
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