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Science 28 July 1995:
Vol. 269. no. 5223, pp. 549 - 552
DOI: 10.1126/science.7624779
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Articles

Science, Vol 269, Issue 5223, 549-552
Copyright © 1995 by American Association for the Advancement of Science

articles

Induction of MHC class I genes in neurons

H Neumann, A Cavalie, DE Jenne, and H Wekerle

Department of Neuroimmunology, Max Planck Institute for Psychiatry, Martinsried, Germany.

Whether neurons express major histocompatibility complex (MHC) class I genes has not been firmly established. The techniques of confocal laser microscopy, patch clamp electrophysiology, and reverse transcriptase-polymerase chain reaction were combined here to directly examine the inducibility of MHC class I genes in individual cultured rat hippocampal neurons. Transcription of MHC class I genes was very rare in neurons with spontaneous action potentials. In electrically silent neurons, transcription was noted, with expression of beta 2-microglobulin under tighter control than in class I heavy chain molecules. Surface expression of class I molecules occurred only in electrically silent neurons treated with interferon gamma. Immunosurveillance by cytotoxic T cells may be focused on functionally impaired neurons.


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