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Science 28 July 1995:
Vol. 269. no. 5223, pp. 543 - 546
DOI: 10.1126/science.7624777
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Articles

Science, Vol 269, Issue 5223, 543-546
Copyright © 1995 by American Association for the Advancement of Science

articles

Weight-reducing effects of the plasma protein encoded by the obese gene

JL Halaas, KS Gajiwala, M Maffei, SL Cohen, BT Chait, D Rabinowitz, RL Lallone, SK Burley, and JM Friedman

Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA.

The gene product of the ob locus is important in the regulation of body weight. The ob product was shown to be present as a 16-kilodalton protein in mouse and human plasma but was undetectable in plasma from C57BL/6J ob/ob mice. Plasma levels of this protein were increased in diabetic (db) mice, a mutant thought to be resistant to the effects of ob. Daily intraperitoneal injections of either mouse or human recombinant OB protein reduced the body weight of ob/ob mice by 30 percent after 2 weeks of treatment with no apparent toxicity but had no effect on db/db mice. The protein reduced food intake and increased energy expenditure in ob/ob mice. Injections of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores.


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Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.
J. Zhang, M. K. Matheny, N. Tumer, M. K. Mitchell, and P. J. Scarpace (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R868-R874
   Abstract »    Full Text »    PDF »
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.
N. Sharma, I. C. Okere, M. K. Duda, D. J. Chess, K. M. O'Shea, and W. C. Stanley (2007)
Cardiovasc Res 73, 257-268
   Abstract »    Full Text »    PDF »
Making Sense of It: Roles of the Sensory Circumventricular Organs in Feeding and Regulation of Energy Homeostasis.
M. Fry, T. D. Hoyda, and A. V. Ferguson (2007)
Experimental Biology and Medicine 232, 14-26
   Abstract »    Full Text »    PDF »
Altered Hypothalamic Leptin, Insulin, and Melanocortin Binding Associated with Moderate-Fat Diet and Predisposition to Obesity.
B. G. Irani, A. A. Dunn-Meynell, and B. E. Levin (2007)
Endocrinology 148, 310-316
   Abstract »    Full Text »    PDF »
Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo.
S. Fishman, R. H. Muzumdar, G. Atzmon, X. Ma, X. Yang, F. H. Einstein, and N. Barzilai (2007)
FASEB J 21, 53-60
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Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics.
R.-E. W. Kavey, V. Allada, S. R. Daniels, L. L. Hayman, B. W. McCrindle, J. W. Newburger, R. S. Parekh, and J. Steinberger (2006)
Circulation 114, 2710-2738
   Abstract »    Full Text »    PDF »
A possible role for melanocortin peptides in longitudinal growth.
J. K Yeh, J. F Evans, Q.-T. Niu, and J. F Aloia (2006)
J. Endocrinol. 191, 677-686
   Abstract »    Full Text »    PDF »
Impairment of Dendritic Cell Functionality and Steady-State Number in Obese Mice.
L. Macia, M. Delacre, G. Abboud, T.-S. Ouk, A. Delanoye, C. Verwaerde, P. Saule, and I. Wolowczuk (2006)
J. Immunol. 177, 5997-6006
   Abstract »    Full Text »    PDF »
Type-2 diabetes: a cocktail of genetic discovery.
H. Freeman and R.D. Cox (2006)
Hum. Mol. Genet. 15, R202-R209
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Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor..
J Kratzsch, I Knerr, A Galler, T Kapellen, K Raile, A Korner, J Thiery, J Dotsch, and W Kiess (2006)
Eur. J. Endocrinol. 155, 609-614
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Regulation of corticotropin-releasing factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress..
Q. Huang, E. Timofeeva, and D. Richard (2006)
J. Endocrinol. 191, 179-188
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Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance.
A. U. Momin, N. Melikian, A. M. Shah, D. J. Grieve, S. B. Wheatcroft, L. John, A. El Gamel, J. B. Desai, T. Nelson, C. Driver, et al. (2006)
Eur. Heart J. 27, 2294-2299
   Abstract »    Full Text »    PDF »
Modulation of Adipokines and Cytokines in Gestational Diabetes and Macrosomia.
J.-M. Ategbo, O. Grissa, A. Yessoufou, A. Hichami, K. L. Dramane, K. Moutairou, A. Miled, A. Grissa, M. Jerbi, Z. Tabka, et al. (2006)
J. Clin. Endocrinol. Metab. 91, 4137-4143
   Abstract »    Full Text »    PDF »


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