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Science 28 July 1995: Vol. 269. no. 5223, pp. 535 - 537 DOI: 10.1126/science.7542801
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Articles
Science, Vol 269, Issue 5223, 535-537
Copyright © 1995 by American Association for the Advancement of Science
A role for CD5 in TCR-mediated signal transduction and thymocyte selection
A Tarakhovsky,
SB Kanner,
J Hombach,
JA Ledbetter,
W Muller,
N Killeen,
and
K Rajewsky
Institute for Genetics, University of Cologne, Germany.
CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.
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