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Science 28 July 1995:
Vol. 269. no. 5223, pp. 535 - 537
DOI: 10.1126/science.7542801

Articles

Science, Vol 269, Issue 5223, 535-537
Copyright © 1995 by American Association for the Advancement of Science


articles

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

A Tarakhovsky, SB Kanner, J Hombach, JA Ledbetter, W Muller, N Killeen, and K Rajewsky

Institute for Genetics, University of Cologne, Germany.

CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.


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J. Immunol. 166, 2163-2166
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Critical Relationship Between TCR Signaling Potential and TCR Affinity During Thymocyte Selection.
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Cloning and Functional Characterization of the Early-Lymphocyte-Specific Pb99 Gene.
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The Src-Homology Domain 2-Bearing Protein Tyrosine Phosphatase-1 Inhibits Antigen Receptor-Induced Apoptosis of Activated Peripheral T Cells.
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CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity.
H. S. Azzam, A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love (1998)
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J. Immunol. 161, 5817-5820
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Human CD5 Signaling and Constitutive Phosphorylation of C-Terminal Serine Residues by Casein Kinase II.
J. Calvo, J. M. Vilda, L. Places, M. Simarro, O. Padilla, D. Andreu, K. S. Campbell, C. Aussel, and F. Lozano (1998)
J. Immunol. 161, 6022-6029
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Cutting Edge: Negative Regulation of Human T Cell Activation by the Receptor-Type Protein Tyrosine Phosphatase CD148.
S. G. Tangye, J. Wu, G. Aversa, J. E. de Vries, L. L. Lanier, and J. H. Phillips (1998)
J. Immunol. 161, 3803-3807
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CD3/TCR Complex-Associated Lymphocyte Activation Gene-3 Molecules Inhibit CD3/TCR Signaling.
S. Hannier, M. Tournier, G. Bismuth, and F. Triebel (1998)
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Regulation of Casein Kinase 2 by Direct Interaction with Cell Surface Receptor CD5.
C. Raman, A. Kuo, J. Deshane, D. W. Litchfield, and R. P. Kimberly (1998)
J. Biol. Chem. 273, 19183-19189
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An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells.
R. Berland and H. H. Wortis (1998)
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The Structure of Avian CD5 Implies a Conserved Function.
R. Koskinen, T. W. F. Gobel, C. A. Tregaskes, J. R. Young, and O. Vainio (1998)
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Natural and Engineered Disorders of Lymphocyte Development.
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