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Science 14 July 1995:
Vol. 269. no. 5221, pp. 227 - 230
DOI: 10.1126/science.7542404
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Articles

Science, Vol 269, Issue 5221, 227-230
Copyright © 1995 by American Association for the Advancement of Science

articles

CD1-restricted T cell recognition of microbial lipoglycan antigens

PA Sieling, D Chatterjee, SA Porcelli, TI Prigozy, RJ Mazzaccaro, T Soriano, BR Bloom, MB Brenner, M Kronenberg, PJ Brennan, and al. et

Division of Dermatology, University of California at Los Angeles (UCLA) School of Medicine 90095, USA.

It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.


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   Abstract »    Full Text »    PDF »
At Least One Class I Gene in Restriction Fragment Pattern-Y (Rfp-Y), the Second MHC Gene Cluster in the Chicken, Is Transcribed, Polymorphic, and Shows Divergent Specialization in Antigen Binding Region.
M. Afanassieff, R. M. Goto, J. Ha, M. A. Sherman, L. Zhong, C. Auffray, F. Coudert, R. Zoorob, and M. M. Miller (2001)
J. Immunol. 166, 3324-3333
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The A' and F' Pockets of Human CD1b Are Both Required for Optimal Presentation of Lipid Antigens to T Cells.
K. R. Niazi, M. W. Chiu, R. M. Mendoza, M. Degano, S. Khurana, D. B. Moody, A. Melian, I. A. Wilson, M. Kronenberg, S. A. Porcelli, et al. (2001)
J. Immunol. 166, 2562-2570
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Activation-induced expression of CD1d antigen on mature T cells.
M. del C. Salamone, G. A. Rabinovich, A. K. Mendiguren, G. V. Salamone, and L. Fainboim (2001)
J. Leukoc. Biol. 69, 207-214
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Glycolipid Antigen Processing for Presentation by CD1d Molecules.
T. I. Prigozy, O. Naidenko, P. Qasba, D. Elewaut, L. Brossay, A. Khurana, T. Natori, Y. Koezuka, A. Kulkarni, and M. Kronenberg (2001)
Science 291, 664-667
   Abstract »    Full Text »
Group 1 CD1 Genes in Rabbit.
S. M. Hayes and K. L. Knight (2001)
J. Immunol. 166, 403-410
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Lipoprotein Access to MHC Class I Presentation During Infection of Murine Macrophages with Live Mycobacteria.
O. Neyrolles, K. Gould, M.-P. Gares, S. Brett, R. Janssen, P. O'Gaora, J.-L. Herrmann, M.-C. Prevost, E. Perret, J. E. R. Thole, et al. (2001)
J. Immunol. 166, 447-457
   Abstract »    Full Text »    PDF »
Genetic Dissection of Primary and Secondary Responses to a Widespread Natural Pathogen of the Gut, Eimeria vermiformis.
A. L. Smith and A. C. Hayday (2000)
Infect. Immun. 68, 6273-6280
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Human Double-Negative T Cells in Systemic Lupus Erythematosus Provide Help for IgG and Are Restricted by CD1c.
P. A. Sieling, S. A. Porcelli, B. T. Duong, F. Spada, B. R. Bloom, B. Diamond, and B. H. Hahn (2000)
J. Immunol. 165, 5338-5344
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Molecular Recognition of Human CD1b Antigen Complexes: Evidence for a Common Pattern of Interaction with {alpha}{beta} TCRs.
A. Melian, G. F. M. Watts, A. Shamshiev, G. De Libero, A. Clatworthy, M. Vincent, M. B. Brenner, S. Behar, K. Niazi, R. L. Modlin, et al. (2000)
J. Immunol. 165, 4494-4504
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Cd1b-Mediated T Cell Recognition of a Glycolipid Antigen Generated from Mycobacterial Lipid and Host Carbohydrate during Infection.
D. B. Moody, M. R. Guy, E. Grant, T.-Y. Cheng, M. B. Brenner, G. S. Besra, and S. A. Porcelli (2000)
J. Exp. Med. 192, 965-976
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Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo.
K. Kakimi, L. G. Guidotti, Y. Koezuka, and F. V. Chisari (2000)
J. Exp. Med. 192, 921-930
   Abstract »    Full Text »    PDF »
Review: Lipopolysaccharides in the development of the Guillain-Barre syndrome and Miller Fisher syndrome forms of acute inflammatory peripheral neuropathies.
M. M. Prendergast and A. P. Moran (2000)
Innate Immunity 6, 341-359
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Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules.
M. J. Soloski, M. E. Szperka, A. Davies, and S. L. Wooden (2000)
Experimental Biology and Medicine 224, 231-239
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The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent.
K. Tsujimura, Y. Obata, S. Iwase, Y. Matsudaira, S. Ozeki, and T. Takahashi (2000)
Int. Immunol. 12, 1217-1225
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CD4+ V{alpha}14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major.
H. Ishikawa, H. Hisaeda, M. Taniguchi, T. Nakayama, T. Sakai, Y. Maekawa, Y. Nakano, M. Zhang, T. Zhang, M. Nishitani, et al. (2000)
Int. Immunol. 12, 1267-1274
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Comparison of the T Cell Patterns in Leprous and Cutaneous Sarcoid Granulomas : Presence of V{alpha}24-Invariant Natural Killer T Cells in T-Cell-Reactive Leprosy Together with a Highly Biased T Cell Receptor V{alpha} Repertoire.
M. Mempel, B. Flageul, F. Suarez, C. Ronet, L. Dubertret, P. Kourilsky, G. Gachelin, and P. Musette (2000)
Am. J. Pathol. 157, 509-523
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Glycosyl-Phosphatidylinositol Reanchoring Unmasks Distinct Antigen-Presenting Pathways for CD1b and CD1c.
D. H. Geho, J. D. Fayen, R. M. Jackman, D. B. Moody, S. A. Porcelli, and M. L. Tykocinski (2000)
J. Immunol. 165, 1272-1277
   Abstract »    Full Text »    PDF »
Inhibition of Human NK Cell-Mediated Killing by CD1 Molecules.
E. Carbone, G. Terrazzano, A. Melian, D. Zanzi, L. Moretta, S. Porcelli, K. Karre, and S. Zappacosta (2000)
J. Immunol. 164, 6130-6137
   Abstract »    Full Text »    PDF »
CD1 expression in psoriatic and rheumatoid arthritis.
A. Cauli, C. Pitzalis, G. Yanni, M. Awad, and G. S. Panayi (2000)
Rheumatology 39, 666-673
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Cutting Edge: The IgG Response to the Circumsporozoite Protein Is MHC Class II-Dependent and CD1d-Independent: Exploring the Role of GPIs in NK T Cell Activation and Antimalarial Responses.
A. Molano, S.-H. Park, Y.-H. Chiu, S. Nosseir, A. Bendelac, and M. Tsuji (2000)
J. Immunol. 164, 5005-5009
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Interleukin-7 or Interleukin-15 Enhances Survival of Mycobacterium tuberculosis-Infected Mice.
M. J. Maeurer, P. Trinder, G. Hommel, W. Walter, K. Freitag, D. Atkins, and S. Storkel (2000)
Infect. Immun. 68, 2962-2970
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