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Science 7 July 1995:
Vol. 269. no. 5220, pp. 92 - 95
DOI: 10.1126/science.7604285
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Articles

Science, Vol 269, Issue 5220, 92-95
Copyright © 1995 by American Association for the Advancement of Science

articles

HERG, a human inward rectifier in the voltage-gated potassium channel family

MC Trudeau, JW Warmke, B Ganetzky, and GA Robertson

Department of Physiology, University of Wisconsin Medical School, Madison 53706, USA.

In contrast to other members of the Eag family of voltage-gated, outwardly rectifying potassium channels, the human eag-related gene (HERG) has now been shown to encode an inwardly rectifying potassium channel. The properties of HERG channels are consistent with the gating properties of Eag-related and other outwardly rectifying, S4-containing potassium channels, but with the addition of an inactivation mechanism that attenuates potassium efflux during depolarization. Because mutations in HERG cause a form of long-QT syndrome, these properties of HERG channel function may be critical to the maintenance of normal cardiac rhythmicity.


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Molecular Diversity and Regulation of Renal Potassium Channels.
S. C. Hebert, G. Desir, G. Giebisch, and W. Wang (2005)
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   Abstract »    Full Text »    PDF »
Regulation of Cardiac IKs Potassium Current by Membrane Phosphatidylinositol 4,5-Bisphosphate.
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   Abstract »    Full Text »    PDF »
Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate.
E. Gopal, Y.-J. Fei, M. Sugawara, S. Miyauchi, L. Zhuang, P. Martin, S. B. Smith, P. D. Prasad, and V. Ganapathy (2004)
J. Biol. Chem. 279, 44522-44532
   Abstract »    Full Text »    PDF »
Cardiac IKr Channels Minimally Comprise hERG 1a and 1b Subunits.
E. M. C. Jones, E. C. Roti Roti, J. Wang, S. A. Delfosse, and G. A. Robertson (2004)
J. Biol. Chem. 279, 44690-44694
   Abstract »    Full Text »    PDF »
Voltage-Gated Potassium Channels in Cell Proliferation.
L. A. Pardo (2004)
Physiology 19, 285-292
   Abstract »    Full Text »    PDF »
Rb+ Flux through hERG Channels Affects the Potency of Channel Blocking Drugs: Correlation with Data Obtained Using a High-Throughput Rb+ Efflux Assay.
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   Abstract »    PDF »
Muscarinic modulation of erg potassium current.
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Pharmacological rescue of trafficking defective HERG channels formed by coassembly of wild-type and long QT mutant N470D subunits.
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Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.
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Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.
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   Abstract »    Full Text »    PDF »
Potassium andlong QT syndrome: A new look at an old therapy.
E. Bisinov, J. H. Mitchell, and C. T. January (2003)
J. Am. Coll. Cardiol. 42, 1783-1784
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Acceleration of human myoblast fusion by depolarization: graded Ca2+ signals involved.
J.-H. Liu, S. Konig, M. Michel, S. Arnaudeau, J. Fischer-Lougheed, C. R. Bader, and L. Bernheim (2003)
Development 130, 3437-3446
   Abstract »    Full Text »    PDF »
APETx1, a New Toxin from the Sea Anemone Anthopleura elegantissima, Blocks Voltage-Gated Human Ether-a-go-go-Related Gene Potassium Channels.
S. Diochot, E. Loret, T. Bruhn, L. Beress, and M. Lazdunski (2003)
Mol. Pharmacol. 64, 59-69
   Abstract »    Full Text »    PDF »
Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine.
J M Ridley, J T Milnes, Y H Zhang, H J Witchel, and J C Hancox (2003)
J. Physiol. 549, 667-672
   Abstract »    Full Text »    PDF »
Saxitoxin Is a Gating Modifier of hERG K+ Channels.
J. Wang, J. J. Salata, and P. B. Bennett (2003)
J. Gen. Physiol. 121, 583-598
   Abstract »    Full Text »    PDF »
Voltage-Dependent Profile of Human Ether-a-go-go-Related Gene Channel Block Is Influenced by a Single Residue in the S6 Transmembrane Domain.
J. A. Sanchez-Chapula, T. Ferrer, R. A. Navarro-Polanco, and M. C. Sanguinetti (2003)
Mol. Pharmacol. 63, 1051-1058
   Abstract »    Full Text »    PDF »
Modulation of human ether-a-go-go-related K+ (HERG) channel inactivation by Cs+ and K+.
S. Zhang, S. J Kehl, and D. Fedida (2003)
J. Physiol. 548, 691-702
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Caenorhabditis elegans UNC-103 ERG-Like Potassium Channel Regulates Contractile Behaviors of Sex Muscles in Males before and during Mating.
L. R. Garcia and P. W. Sternberg (2003)
J. Neurosci. 23, 2696-2705
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Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency.
K. Ishii, M. Nagai, M. Takahashi, and M. Endoh (2003)
Cardiovasc Res 57, 651-659
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Cloning and Functional Characterization of the Smooth Muscle Ether-a-go-go-related Gene K+ Channel. POTENTIAL ROLE OF A CONSERVED AMINO ACID SUBSTITUTION IN THE S4 REGION.
F. Shoeb, A. P. Malykhina, and H. I. Akbarali (2003)
J. Biol. Chem. 278, 2503-2514
   Abstract »    Full Text »    PDF »
Functional and pharmacological properties of canine ERG potassium channels.
J. Wang, K. Della Penna, H. Wang, J. Karczewski, T. M. Connolly, K. S. Koblan, P. B. Bennett, and J. J. Salata (2003)
Am J Physiol Heart Circ Physiol 284, H256-H267
   Abstract »    Full Text »    PDF »
Modulation of the ERG K+ Current by the Tyrosine Phosphatase, SHP-1.
F. S. Cayabyab, F. W. L. Tsui, and L. C. Schlichter (2002)
J. Biol. Chem. 277, 48130-48138
   Abstract »    Full Text »    PDF »


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