Science 7 July 1995: Vol. 269. no. 5220, pp. 79 - 81 DOI: 10.1126/science.7604283

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Articles

Novel Role for Interleukin-2 Receptor-Jak Signaling in Retrovirus Transmission.

J. M. Taylor, M. Brown, M. Nejmeddine, K. J. Kim, L. Ratner, M. Lairmore, and C. Nicot (2009)
J. Virol. 83, 11467-11476
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Activation of the Interleukin-21 Gene and Its Receptor Gene by Human T-cell Leukemia Virus Type 1 Tax in Human T-cells.

M. Mizuguchi, H. Asao, T. Hara, M. Higuchi, M. Fujii, and M. Nakamura (2009)
J. Biol. Chem. 284, 25501-25511
 |  Abstract »  |  Full Text »  |  PDF »

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.

A. Hosui, A. Kimura, D. Yamaji, B.-m. Zhu, R. Na, and L. Hennighausen (2009)
J. Exp. Med. 206, 819-831
 |  Abstract »  |  Full Text »  |  PDF »

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells.

M. Bellon and C. Nicot (2008)
Blood 112, 2946-2955
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin 21: a cytokine/cytokine receptor system that has come of age.

W. J. Leonard, R. Zeng, and R. Spolski (2008)
J. Leukoc. Biol. 84, 348-356
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening.

L. Supekova, F. Supek, J. Lee, S. Chen, N. Gray, J. P. Pezacki, A. Schlapbach, and P. G. Schultz (2008)
J. Biol. Chem. 283, 29-36
 |  Abstract »  |  Full Text »  |  PDF »

Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein.

J. Cheng, A. R. Kydd, K. Nakase, K. M. Noonan, A. Murakami, H. Tao, M. Dwyer, C. Xu, Q. Zhu, and W. A. Marasco (2007)
Blood 110, 2110-2120
 |  Abstract »  |  Full Text »  |  PDF »

Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation.

R. Hochreiter, C. Ptaschinski, S. L. Kunkel, and R. Rochford (2007)
J. Gen. Virol. 88, 1896-1905
 |  Abstract »  |  Full Text »  |  PDF »

The molecular basis of IL-21-mediated proliferation.

R. Zeng, R. Spolski, E. Casas, W. Zhu, D. E. Levy, and W. J. Leonard (2007)
Blood 109, 4135-4142
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Tat of Human Immunodeficiency Virus Type 1 Activates Lytic Cycle Replication of Kaposi's Sarcoma-Associated Herpesvirus: Role of JAK/STAT Signaling.

Y. Zeng, X. Zhang, Z. Huang, L. Cheng, S. Yao, D. Qin, X. Chen, Q. Tang, Z. Lv, L. Zhang, et al. (2007)
J. Virol. 81, 2401-2417
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1.

J. Arnold, B. Yamamoto, M. Li, A. J. Phipps, I. Younis, M. D. Lairmore, and P. L. Green (2006)
Blood 107, 3976-3982
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I.

T. Higashi, J. Tsukada, Y. Yoshida, T. Mizobe, F. Mouri, Y. Minami, H. Morimoto, and Y. Tanaka (2005)
Genes Cells 10, 1153-1162
 |  Abstract »  |  Full Text »  |  PDF »

Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-{kappa}B, as a strategy for chemoprevention and therapy of adult T-cell leukemia.

M. Watanabe, T. Ohsugi, M. Shoda, T. Ishida, S. Aizawa, M. Maruyama-Nagai, A. Utsunomiya, S. Koga, Y. Yamada, S. Kamihira, et al. (2005)
Blood 106, 2462-2471
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant gene expression by CD25+CD4+ immunoregulatory T cells in autoimmune-prone rats carrying the human T cell leukemia virus type-I gene.

H. Hayase, A. Ishizu, H. Ikeda, Y. Miyatake, T. Baba, M. Higuchi, A. Abe, U. Tomaru, and T. Yoshiki (2005)
Int. Immunol. 17, 677-684
 |  Abstract »  |  Full Text »  |  PDF »

Differential STAT5 Signaling by Ligand-dependent and Constitutively Active Cytokine Receptors.

V. Moucadel and S. N. Constantinescu (2005)
J. Biol. Chem. 280, 13364-13373
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Jak/STAT pathway for immunosuppression.

J J O'Shea (2004)
Ann Rheum Dis 63, ii67-ii71
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SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER.

H. Siavash, N.G. Nikitakis, and J.J. Sauk (2004)
Critical Reviews in Oral Biology & Medicine 15, 298-307
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Conserved Motif in the STAT Family That Is Required for Tyrosine Phosphorylation.

A. M. Gamero, S. Sakamoto, J. Montenegro, and A. C. Larner (2004)
J. Biol. Chem. 279, 12379-12385
 |  Abstract »  |  Full Text »  |  PDF »

Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.

J. L. Roberts, A. Lengi, S. M. Brown, M. Chen, Y.-J. Zhou, J. J. O'Shea, and R. H. Buckley (2004)
Blood 103, 2009-2018
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Thioredoxin-Binding Protein-2/Vitamin D3 Up-Regulated Protein 1 in Human T-Cell Leukemia Virus Type I-Dependent T-Cell Transformation: Implications for Adult T-Cell Leukemia Leukemogenesis.

Y. Nishinaka, A. Nishiyama, H. Masutani, S.-i. Oka, K. Md. Ahsan, Y. Nakayama, Y. Ishii, H. Nakamura, M. Maeda, and J. Yodoi (2004)
Cancer Res. 64, 1287-1292
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis.

D. W. Sternberg and D. G. Gilliland (2004)
J. Clin. Oncol. 22, 361-371
 |  Abstract »  |  Full Text »  |  PDF »

Dysregulated Expression of COOH-Terminally Truncated Stat5 and Loss of IL2-Inducible Stat5-Dependent Gene Expression in Sezary Syndrome.

T. J. Mitchell, S. J. Whittaker, and S. John (2003)
Cancer Res. 63, 9048-9054
 |  Abstract »  |  Full Text »  |  PDF »

Roscovitine Inhibits STAT5 Activity and Induces Apoptosis in the Human Leukemia Virus Type 1-Transformed Cell Line MT-2.

S. Mohapatra, B. Chu, S. Wei, J. Djeu, P. K. Epling-Burnette, T. Loughran, R. Jove, and W. J. Pledger (2003)
Cancer Res. 63, 8523-8530
 |  Abstract »  |  Full Text »  |  PDF »

Methylation-Mediated Silencing of SOCS-1 Gene in Hepatocellular Carcinoma Derived from Cirrhosis.

O. Okochi, K. Hibi, M. Sakai, S. Inoue, S. Takeda, T. Kaneko, and A. Nakao (2003)
Clin. Cancer Res. 9, 5295-5298
 |  Abstract »  |  Full Text »  |  PDF »

Human T-Cell Lymphotropic Virus Type 1 p12I Enhances Interleukin-2 Production during T-Cell Activation.

W. Ding, S.-J. Kim, A. M. Nair, B. Michael, K. Boris-Lawrie, A. Tripp, G. Feuer, and M. D. Lairmore (2003)
J. Virol. 77, 11027-11039
 |  Abstract »  |  Full Text »  |  PDF »

Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma.

J. A. Kelly, R. Spolski, P. E. Kovanen, T. Suzuki, J. Bollenbacher, C. A. Pise-Masison, M. F. Radonovich, S. Lee, N. A. Jenkins, N. G. Copeland, et al. (2003)
J. Exp. Med. 198, 79-89
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease.

P. Lovato, C. Brender, J. Agnholt, J. Kelsen, K. Kaltoft, A. Svejgaard, K. W. Eriksen, A. Woetmann, and N. Odum (2003)
J. Biol. Chem. 278, 16777-16781
 |  Abstract »  |  Full Text »  |  PDF »

Signal transducer and activator of transcription proteins in leukemias.

M. Benekli, M. R. Baer, H. Baumann, and M. Wetzler (2003)
Blood 101, 2940-2954
 |  Abstract »  |  Full Text »  |  PDF »

Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages.

J. J. Kohler, D. L. Tuttle, C. R. Coberley, J. W. Sleasman, and M. M. Goodenow (2003)
J. Leukoc. Biol. 73, 407-416
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies.

F. Ravandi, M. Talpaz, and Z. Estrov (2003)
Clin. Cancer Res. 9, 535-550
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat.

M. Okada and K.-T. Jeang (2002)
J. Virol. 76, 12564-12573
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice.

T. Tsuruyama, T. Nakamura, G. Jin, M. Ozeki, Y. Yamada, and H. Hiai (2002)
PNAS 99, 8253-8258
 |  Abstract »  |  Full Text »  |  PDF »

Activated STAT Signaling in Human Tumors Provides Novel Molecular Targets for Therapeutic Intervention.

R. Buettner, L. B. Mora, and R. Jove (2002)
Clin. Cancer Res. 8, 945-954
 |  Abstract »  |  Full Text »  |  PDF »

Kaposi's Sarcoma-associated Herpesvirus Open Reading Frame 50 Stimulates the Transcriptional Activity of STAT3.

Y. Gwack, S. Hwang, C. Lim, Y. S. Won, C. H. Lee, and J. Choe (2002)
J. Biol. Chem. 277, 6438-6442
 |  Abstract »  |  Full Text »  |  PDF »

Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma.

Q. Zhang, P. N. Raghunath, L. Xue, M. Majewski, D. F. Carpentieri, N. Odum, S. Morris, T. Skorski, and M. A. Wasik (2002)
J. Immunol. 168, 466-474
 |  Abstract »  |  Full Text »  |  PDF »

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34+ TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor.

C. Bovolenta, E. Pilotti, M. Mauri, M. Turci, P. Ciancianaini, P. Fisicaro, U. Bertazzoni, G. Poli, and C. Casoli (2002)
Blood 99, 224-231
 |  Abstract »  |  Full Text »  |  PDF »

HVMNE, a novel lymphocryptovirus related to Epstein-Barr virus, induces lymphoma in New Zealand White rabbits.

M. G. Ferrari, E. D. Rivadeneira, R. Jarrett, L. Stevceva, S. Takemoto, P. Markham, and G. Franchini (2001)
Blood 98, 2193-2199
 |  Abstract »  |  Full Text »  |  PDF »

The deubiquitinating enzyme DUB-2 prolongs cytokine-induced signal transducers and activators of transcription activation and suppresses apoptosis following cytokine withdrawal.

T.-S. Migone, M. Humbert, A. Rascle, D. Sanden, A. D'Andrea, and J. A. Johnston (2001)
Blood 98, 1935-1941
 |  Abstract »  |  Full Text »  |  PDF »

HTLV-1 p12I protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.

C. Nicot, J. C. Mulloy, M. G. Ferrari, J. M. Johnson, K. Fu, R. Fukumoto, R. Trovato, J. Fullen, W. J. Leonard, and G. Franchini (2001)
Blood 98, 823-829
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The Common {{gamma}}-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex.

H. Asao, C. Okuyama, S. Kumaki, N. Ishii, S. Tsuchiya, D. Foster, and K. Sugamura (2001)
J. Immunol. 167, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

IL-2R{{alpha}}-Directed Monoclonal Antibodies Provide Effective Therapy in a Murine Model of Adult T-Cell Leukemia by a Mechanism other than Blockade of IL-2/IL-2R{{alpha}} Interaction.

K. E. Phillips, B. Herring, L. A. Wilson, M. S. Rickford, M. Zhang, C. K. Goldman, J. Y. Tso, and T. A. Waldmann (2000)
Cancer Res. 60, 6977-6984
 |  Abstract »  |  Full Text »

Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1.

S. Zhang, V. A. Lawless, and M. H. Kaplan (2000)
J. Immunol. 165, 6270-6277
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive activation of STAT3 is associated with the acquisition of an interleukin 6-independent phenotype by murine plasmacytomas and hybridomas.

R. Rawat, G. J. Rainey, C. D. Thompson, M. R. Frazier-Jessen, R. T. Brown, and R. P. Nordan (2000)
Blood 96, 3514-3521
 |  Abstract »  |  Full Text »  |  PDF »

Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells.

R. A. Kirken, R. A. Erwin, L. Wang, Y. Wang, H. Rui, and W. L. Farrar (2000)
J. Immunol. 165, 5097-5104
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Phosphotyrosine Phosphatase SHP-1 Expression in Malignant T-Cell Lymphoma Cells Results from Methylation of the SHP-1 Promoter.

Q. Zhang, P. N. Raghunath, E. Vonderheid, N. Odum, and M. A. Wasik (2000)
Am. J. Pathol. 157, 1137-1146
 |  Abstract »  |  Full Text »  |  PDF »

Lentivirus Infection in the Brain Induces Matrix Metalloproteinase Expression: Role of Envelope Diversity.

J. B. Johnston, Y. Jiang, G. van Marle, M. B. Mayne, W. Ni, J. Holden, J. C. McArthur, and C. Power (2000)
J. Virol. 74, 7211-7220
 |  Abstract »  |  Full Text »

Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.

C. Nicot, R. Mahieux, S. Takemoto, and G. Franchini (2000)
Blood 96, 275-281
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga (2000)
Blood 95, 3765-3770
 |  Abstract »  |  Full Text »  |  PDF »

TEL-JAK2 transgenic mice develop T-cell leukemia.

C. Carron, F. Cormier, A. Janin, V. Lacronique, M. Giovannini, M.-T. Daniel, O. Bernard, and J. Ghysdael (2000)
Blood 95, 3891-3899
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive activation of LIL-Stat in adult T-cell leukemia cells.

J. Tsukada, Y. Toda, M. Misago, Y. Tanaka, P. E. Auron, and S. Eto (2000)
Blood 95, 2715-2718
 |  Abstract »  |  Full Text »  |  PDF »

Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NFkappa B or CREB/ATF Activation Fail To Transform Primary Human T Cells.

T. M. Ross, M. Narayan, Z.-Y. Fang, A. C. Minella, and P. L. Green (2000)
J. Virol. 74, 2655-2662
 |  Abstract »  |  Full Text »

Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation.

Y.-T. Tsai, Y.-H. Su, S.-S. Fang, T.-N. Huang, Y. Qiu, Y.-S. Jou, H.-m. Shih, H.-J. Kung, and R.-H. Chen (2000)
Mol. Cell. Biol. 20, 2043-2054
 |  Abstract »  |  Full Text »

Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains.

M. Chen, A. Cheng, F. Candotti, Y.-J. Zhou, A. Hymel, A. Fasth, L. D. Notarangelo, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 947-956
 |  Abstract »  |  Full Text »

Interferon-gamma Has Dual Potentials in Inhibiting or Promoting Cell Proliferation.

H. Asao and X.-Y. Fu (2000)
J. Biol. Chem. 275, 867-874
 |  Abstract »  |  Full Text »  |  PDF »

Cytosolic Tyrosine Dephosphorylation of STAT5. POTENTIAL ROLE OF SHP-2 IN STAT5 REGULATION.

C.-L. Yu, Y.-J. Jin, and S. J. Burakoff (2000)
J. Biol. Chem. 275, 599-604
 |  Abstract »  |  Full Text »  |  PDF »

The Jak-Stat pathway in normal and perturbed hematopoiesis.

A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
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Proliferation Response to Interleukin-2 and Jak/Stat Activation of T Cells Immortalized by Human T-Cell Lymphotropic Virus Type 1 Is Independent of Open Reading Frame I Expression.

N. D. Collins, C. D'Souza, B. Albrecht, M. D. Robek, L. Ratner, W. Ding, P. L. Green, and M. D. Lairmore (1999)
J. Virol. 73, 9642-9649
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein.

J. Turkson, T. Bowman, J. Adnane, Y. Zhang, J. Y. Djeu, M. Sekharam, D. A. Frank, L. B. Holzman, J. Wu, S. Sebti, et al. (1999)
Mol. Cell. Biol. 19, 7519-7528
 |  Abstract »  |  Full Text »  |  PDF »

The Human Homologue of the Yeast Proteins Skb1 and Hsl7p Interacts with Jak Kinases and Contains Protein Methyltransferase Activity.

B. P. Pollack, S. V. Kotenko, W. He, L. S. Izotova, B. L. Barnoski, and S. Pestka (1999)
J. Biol. Chem. 274, 31531-31542
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transducer and Activator of Transcription 5a Influences Mammary Epithelial Cell Survival and Tumorigenesis.

R. C. Humphreys and L. Hennighausen (1999)
Cell Growth Differ. 10, 685-694
 |  Abstract »  |  Full Text »

A Novel Epstein-Barr Virus-Like Virus, HVMNE, in a Macaca Nemestrina With Mycosis Fungoides.

E.D. Rivadeneira, M.G. Ferrari, R.F. Jarrett, A.A. Armstrong, P. Markham, T. Birkebak, S. Takemoto, C. Johnson-Delaney, J. Pecon-Slattery, E.A. Clark, et al. (1999)
Blood 94, 2090-2101
 |  Abstract »  |  Full Text »  |  PDF »

STAT5 Activation by BCR-Abl Contributes to Transformation of K562 Leukemia Cells.

R. P. de Groot, J. A.M. Raaijmakers, J.-W. J. Lammers, R. Jove, and L. Koenderman (1999)
Blood 94, 1108-1112
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of a Novel STAM-associated Molecule "AMSH" in Intracellular Signal Transduction Mediated by Cytokines.

N. Tanaka, K. Kaneko, H. Asao, H. Kasai, Y. Endo, T. Fujita, T. Takeshita, and K. Sugamura (1999)
J. Biol. Chem. 274, 19129-19135
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.

P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells).

H. Bao, S. M. Jacobs-Helber, A. E. Lawson, K. Penta, A. Wickrema, and S. T. Sawyer (1999)
Blood 93, 3757-3773
 |  Abstract »  |  Full Text »  |  PDF »

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response.

L. H. Wang, R. A. Kirken, R. A. Erwin, C.-R. Yu, and W. L. Farrar (1999)
J. Immunol. 162, 3897-3904
 |  Abstract »  |  Full Text »  |  PDF »

The Lck Binding Domain of Herpesvirus Saimiri Tip-484 Constitutively Activates Lck and STAT3 in T Cells.

T. C. Lund, P. C. Prator, M. M. Medveczky, and P. G. Medveczky (1999)
J. Virol. 73, 1689-1694
 |  Abstract »  |  Full Text »

Defective Internalization and Sustained Activation of Truncated Granulocyte Colony-Stimulating Factor Receptor Found in Severe Congenital Neutropenia/Acute Myeloid Leukemia.

A. C. Ward, Y. M. van Aesch, A. M. Schelen, and I. P. Touw (1999)
Blood 93, 447-458
 |  Abstract »  |  Full Text »  |  PDF »

The PTK-STAT Signaling Pathway Has Essential Roles in T-cell Activation in Response to Antigen Stimulation.

T. WELTE, D. LEITENBERG, B.N. DITTEL, B.K. AL-RAMADI, W.R. HANSEN, B. XIE, C.A. JANEWAY, A.L.M. BOTHWELL, K. BOTTOMLY, and X.Y. FU (1999)
Cold Spring Harb Symp Quant Biol 64, 291-302
 |  Abstract »  |  PDF »

Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain.

J. C. Mulloy, T. Kislyakova, A. Cereseto, L. Casareto, A. LoMonico, J. Fullen, M. V. Lorenzi, A. Cara, C. Nicot, C.-Z. Giam, et al. (1998)
J. Virol. 72, 8852-8860
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice.

K. Takeda, T. Kaisho, N. Yoshida, J. Takeda, T. Kishimoto, and S. Akira (1998)
J. Immunol. 161, 4652-4660
 |  Abstract »  |  Full Text »  |  PDF »

HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling.

Y.-H. Lee and Y. Yun (1998)
J. Biol. Chem. 273, 25510-25515
 |  Abstract »  |  Full Text »  |  PDF »

Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line.

I. Lemasson, S. Thebault, C. Sardet, C. Devaux, and J.-M. Mesnard (1998)
J. Biol. Chem. 273, 23598-23604
 |  Abstract »  |  Full Text »  |  PDF »

Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells.

L. M.L. Tuyt, K. Bregman, C. Lummen, W. H.A. Dokter, and E. Vellenga (1998)
Blood 92, 1364-1373
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: A Conditionally Active Form of STAT6 Can Mimic Certain Effects of IL-4.

Y. Kamogawa, H. J. Lee, J. A. Johnston, M. McMahon, A. O'Garra, and N. Arai (1998)
J. Immunol. 161, 1074-1077
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Function of Stat1alpha and Stat3 Proteins in Erythropoietin-Induced Erythroid Differentiation of a Human Leukemia Cell Line.

K. Kirito, M. Uchida, M. Takatoku, K. Nakajima, T. Hirano, Y. Miura, and N. Komatsu (1998)
Blood 92, 462-471
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation.

M. Onishi, T. Nosaka, K. Misawa, A. L.-F. Mui, D. Gorman, M. McMahon, A. Miyajima, and T. Kitamura (1998)
Mol. Cell. Biol. 18, 3871-3879
 |  Abstract »  |  Full Text »

Selective Ablation of Human T-Cell Lymphotropic Virus Type 1 p12I Reduces Viral Infectivity In Vivo.

N. D. Collins, G. C. Newbound, B. Albrecht, J. L. Beard, L. Ratner, and M. D. Lairmore (1998)
Blood 91, 4701-4707
 |  Abstract »  |  Full Text »  |  PDF »

Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation.

J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini (1998)
J. Virol. 72, 4408-4412
 |  Abstract »  |  Full Text »  |  PDF »

Human T-Cell Leukemia Virus Type 1 pX-I and pX-II Open Reading Frames Are Dispensable for the Immortalization of Primary Lymphocytes.

M. D. Robek, F.-H. Wong, and L. Ratner (1998)
J. Virol. 72, 4458-4462
 |  Abstract »  |  Full Text »  |  PDF »

Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation.

J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove (1998)
Mol. Cell. Biol. 18, 2545-2552
 |  Abstract »  |  Full Text »

Stat3 Activation Is Required for Cellular Transformation by v-src.

J. F. Bromberg, C. M. Horvath, D. Besser, W. W. Lathem, and J. E. Darnell Jr. (1998)
Mol. Cell. Biol. 18, 2553-2558
 |  Abstract »  |  Full Text »

Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression.

M. H. Kaplan, C. Daniel, U. Schindler, and M. J. Grusby (1998)
Mol. Cell. Biol. 18, 1996-2003
 |  Abstract »  |  Full Text »

Characterization of BCE-1, a Transcriptional Enhancer Regulated by Prolactin and Extracellular Matrix and Modulated by the State of Histone Acetylation.

C. A. Myers, C. Schmidhauser, J. Mellentin-Michelotti, G. Fragoso, C. D. Roskelley, G. Casperson, R. Mossi, P. Pujuguet, G. Hager, and M. J. Bissell (1998)
Mol. Cell. Biol. 18, 2184-2195
 |  Abstract »  |  Full Text »

Infective Dermatitis: A Pabulum for Human T-Lymphotrophic Virus Type I Leukemogenesis?.

E. Tschachler and G. Franchini (1998)
Arch Dermatol 134, 487-488
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Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression.

J. Zamorano, H. Y. Wang, R. Wang, Y. Shi, G. D. Longmore, and A. D. Keegan (1998)
J. Immunol. 160, 3502-3512
 |  Abstract »  |  Full Text »  |  PDF »

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.

T.-S. Migone, N. A. Cacalano, N. Taylor, T. Yi, T. A. Waldmann, and J. A. Johnston (1998)
PNAS 95, 3845-3850
 |  Abstract »  |  Full Text »  |  PDF »

A Human T-cell Leukemia Virus Tax Variant Incapable of Activating NF-kappa B Retains Its Immortalizing Potential for Primary T-lymphocytes.

O. Rosin, C. Koch, I. Schmitt, O. J. Semmes, K.-T. Jeang, and R. Grassmann (1998)
J. Biol. Chem. 273, 6698-6703
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Jak/STAT Signaling by Activation of the Type 1 TNF Receptor.

D. Guo, J. D. Dunbar, C. H. Yang, L. M. Pfeffer, and D. B. Donner (1998)
J. Immunol. 160, 2742-2750
 |  Abstract »  |  Full Text »  |  PDF »

Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappa B site.

N. Azimi, K. Brown, R. N. Bamford, Y. Tagaya, U. Siebenlist, and T. A. Waldmann (1998)
PNAS 95, 2452-2457
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin and Friend Virus gp55 Activate Different JAK/STAT Pathways through the Erythropoietin Receptor in Erythroid Cells.

Y. Yamamura, H. Senda, Y. Kageyama, T. Matsuzaki, M. Noda, and Y. Ikawa (1998)
Mol. Cell. Biol. 18, 1172-1180
 |  Abstract »  |  Full Text »

Cutting Edge: Constitutive Activation of TCR Signaling Molecules in IL-2-Independent Herpesvirus saimiri-Transformed T Cells.

N. Noraz, K. Saha, F. Ottones, S. Smith, and N. Taylor (1998)
J. Immunol. 160, 2042-2045
 |  Abstract »  |  Full Text »  |  PDF »

Genes in the pX region of human T cell leukemia virus I influence Vav phosphorylation in T cells.

W. Mahana, T. M. Zhao, R. Teller, M. A. Robinson, and T. J. Kindt (1998)
PNAS 95, 1782-1787
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of the Human Homolog of Mouse Jak2.

I. Dalal, E. Arpaia, H. Dadi, S. Kulkarni, J. Squire, and C. M. Roifman (1998)
Blood 91, 844-851
 |  Abstract »  |  Full Text »  |  PDF »

Nitric oxide and thiol redox regulation of Janus kinase activity.

R. J. Duhe, G. A. Evans, R. A. Erwin, R. A. Kirken, G. W. Cox, and W. L. Farrar (1998)
PNAS 95, 126-131
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein.

I. Schmitt, O. Rosin, P. Rohwer, M. Gossen, and R. Grassmann (1998)
J. Virol. 72, 633-640
 |  Abstract »  |  Full Text »  |  PDF »

The Association of Atopy with a Gain-of-Function Mutation in the {alpha} Subunit of the Interleukin-4 Receptor.

G. K. K. Hershey, M. F. Friedrich, L. A. Esswein, M. L. Thomas, and T. A. Chatila (1997)
N. Engl. J. Med. 337, 1720-1725
 |  Abstract »  |  Full Text »  |  PDF »

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