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Science 23 June 1995:
Vol. 268. no. 5218, pp. 1763 - 1766
DOI: 10.1126/science.7792602
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Articles

Science, Vol 268, Issue 5218, 1763-1766
Copyright © 1995 by American Association for the Advancement of Science

articles

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA

O Cases, I Seif, J Grimsby, P Gaspar, K Chen, S Pournin, U Muller, M Aguet, C Babinet, JC Shih, and al. et

Centre National de la Recherche Scientifique (CNRS), Unite de Recherche Associee (URA), Institut Curie, Orsay, France.

Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.


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