Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 June 1995:
Vol. 268. no. 5218, pp. 1749 - 1753
DOI: 10.1126/science.7792600
Prev | Table of Contents | Next

Articles

Science, Vol 268, Issue 5218, 1749-1753
Copyright © 1995 by American Association for the Advancement of Science

articles

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

K Savitsky, A Bar-Shira, S Gilad, G Rotman, Y Ziv, L Vanagaite, DA Tagle, S Smith, T Uziel, S Sfez, and al. et

Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.

A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is characterized by cerebellar degeneration, immunodeficiency, chromosomal instability, cancer predisposition, radiation sensitivity, and cell cycle abnormalities. The disease is genetically heterogeneous, with four complementation groups that have been suspected to represent different genes. ATM, which has a transcript of 12 kilobases, was found to be mutated in AT patients from all complementation groups, indicating that it is probably the sole gene responsible for this disorder. A partial ATM complementary DNA clone of 5.9 kilobases encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control. The discovery of ATM should enhance understanding of AT and related syndromes and may allow the identification of AT heterozygotes, who are at increased risk of cancer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Alu-derived intronic splicing enhancer facilitates intronic processing and modulates aberrant splicing in ATM.
T. Pastor, G. Talotti, M. A. Lewandowska, and F. Pagani (2009)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair.
E. Bolderson, D. J. Richard, B.-B. S. Zhou, and K. K. Khanna (2009)
Clin. Cancer Res. 15, 6314-6320
   Abstract »    Full Text »    PDF »
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients.
M. Anheim, B. Monga, M. Fleury, P. Charles, C. Barbot, M. Salih, J. P. Delaunoy, M. Fritsch, L. Arning, M. Synofzik, et al. (2009)
Brain 132, 2688-2698
   Abstract »    Full Text »    PDF »
Clinical spectrum of ataxia-telangiectasia in adulthood.
M.M.M. Verhagen, W. F. Abdo, M. A.A.P. Willemsen, F. B.L. Hogervorst, D. F.C.M. Smeets, J. A.P. Hiel, E. R. Brunt, M. A. van Rijn, D. Majoor Krakauer, R. A. Oldenburg, et al. (2009)
Neurology 73, 430-437
   Abstract »    Full Text »    PDF »
Gaze fixation deficits and their implication in ataxia-telangiectasia.
A G Shaikh, S Marti, A A Tarnutzer, A Palla, T O Crawford, D Straumann, A M Taylor, and D S Zee (2009)
J. Neurol. Neurosurg. Psychiatry 80, 858-864
   Abstract »    Full Text »    PDF »
A Common 9 bp Deletion in the Ataxia-telangiectasia-mutated Gene Is Not Associated with Oral Cancer.
S. SPYRIDONIDOU, C. YAPIJAKIS, E. NKENKE, T. TOYOSHIMA, A. VYLLIOTIS, Z. SEREFOGLOU, F. W. NEUKAM, E. PATSOURIS, and E. VAIRAKTARIS (2009)
Anticancer Res 29, 3191-3193
   Abstract »    Full Text »    PDF »
PTIP Regulates 53BP1 and SMC1 at the DNA Damage Sites.
J. Wu, M. J. Prindle, G. R. Dressler, and X. Yu (2009)
J. Biol. Chem. 284, 18078-18084
   Abstract »    Full Text »    PDF »
Oxidative Stress Is Linked to ERK1/2-p16 Signaling-mediated Growth Defect in ATM-deficient Astrocytes.
J. Kim and P. K. Y. Wong (2009)
J. Biol. Chem. 284, 14396-14404
   Abstract »    Full Text »    PDF »
Chromatin remodeling finds its place in the DNA double-strand break response.
T. K. Pandita and C. Richardson (2009)
Nucleic Acids Res. 37, 1363-1377
   Abstract »    Full Text »    PDF »
Advances in Radiotherapy and Implications for the Next Century: A Historical Perspective.
P. P. Connell and S. Hellman (2009)
Cancer Res. 69, 383-392
   Full Text »    PDF »
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
A. H. Hakonen, S. Goffart, S. Marjavaara, A. Paetau, H. Cooper, K. Mattila, M. Lampinen, A. Sajantila, T. Lonnqvist, J. N. Spelbrink, et al. (2008)
Hum. Mol. Genet. 17, 3822-3835
   Abstract »    Full Text »    PDF »
Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation.
M. D. Rainey, M. E. Charlton, R. V. Stanton, and M. B. Kastan (2008)
Cancer Res. 68, 7466-7474
   Abstract »    Full Text »    PDF »
A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response.
J. J. Seidel, C. M. Anderson, and E. H. Blackburn (2008)
Mol. Cell. Biol. 28, 5736-5746
   Abstract »    Full Text »    PDF »
Maintenance of Mitochondrial DNA by the Caenorhabditis elegans ATR Checkpoint Protein ATL-1.
C. Mori, T. Takanami, and A. Higashitani (2008)
Genetics 180, 681-686
   Abstract »    Full Text »    PDF »
Variants in the ATM Gene Associated with a Reduced Risk of Contralateral Breast Cancer.
P. Concannon, R. W. Haile, A.-L. Borresen-Dale, B. S. Rosenstein, R. A. Gatti, S. N. Teraoka, A. T. Diep, L. Jansen, D. P. Atencio, B. Langholz, et al. (2008)
Cancer Res. 68, 6486-6491
   Abstract »    Full Text »    PDF »
Human T-Cell Leukemia Virus Type 1 Tax Attenuates the ATM-Mediated Cellular DNA Damage Response.
C. Chandhasin, R. I. Ducu, E. Berkovich, M. B. Kastan, and S. J. Marriott (2008)
J. Virol. 82, 6952-6961
   Abstract »    Full Text »    PDF »
Tagging Single Nucleotide Polymorphisms in Phosphoinositide-3-Kinase-Related Protein Kinase Genes Involved in DNA Damage "Checkpoints" and Lung Cancer Susceptibility.
Z. Hu, H. Liu, H. Wang, R. Miao, W. Sun, G. Jin, Y. Wang, H. Ma, L. Jin, Q. Wei, et al. (2008)
Clin. Cancer Res. 14, 2887-2891
   Abstract »    Full Text »    PDF »
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
S. A. Rimkus, R. J. Katzenberger, A. T. Trinh, G. E. Dodson, R. S. Tibbetts, and D. A. Wassarman (2008)
Genes & Dev. 22, 1205-1220
   Abstract »    Full Text »    PDF »
DNA Damage Responses: Mechanisms and Roles in Human Disease: 2007 G.H.A. Clowes Memorial Award Lecture.
M. B. Kastan (2008)
Mol. Cancer Res. 6, 517-524
   Abstract »    Full Text »    PDF »
Translation of Genetic Discoveries into Clinical Therapies.
D. G. Hackam and A. S. Hackam (2008)
Ann Intern Med 148, 246-247
   Full Text »    PDF »
Genetic Interactions of the Aspergillus nidulans atmAATM Homolog With Different Components of the DNA Damage Response Pathway.
I. Malavazi, J. F. Lima, P. A. de Castro, M. Savoldi, M. H. de Souza Goldman, and G. H. Goldman (2008)
Genetics 178, 675-691
   Abstract »    Full Text »    PDF »
Greglist: a database listing potential G-quadruplex regulated genes.
R. Zhang, Y. Lin, and C.-T. Zhang (2008)
Nucleic Acids Res. 36, D372-D376
   Abstract »    Full Text »    PDF »
The role of DNA damage repair in aging of adult stem cells.
J. Kenyon and S. L. Gerson (2007)
Nucleic Acids Res.
   Abstract »    Full Text »    PDF »
Ataxia-Telangiectasia Mutated Is Not Required for p53 Induction and Apoptosis in Irradiated Epithelial Tissues.
K. E. Gurley and C. J. Kemp (2007)
Mol. Cancer Res. 5, 1312-1318
   Abstract »    Full Text »    PDF »
Genetic causes of vascular malformations.
P. Brouillard and M. Vikkula (2007)
Hum. Mol. Genet. 16, R140-R149
   Abstract »    Full Text »    PDF »
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
M. Reimann, C. Loddenkemper, C. Rudolph, I. Schildhauer, B. Teichmann, H. Stein, B. Schlegelberger, B. Dorken, and C. A. Schmitt (2007)
Blood 110, 2996-3004
   Abstract »    Full Text »    PDF »
Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.
M.G. Luciani, C. Campregher, and C. Gasche (2007)
Carcinogenesis 28, 2207-2217
   Abstract »    Full Text »    PDF »
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
M. Ambrose, J. V. Goldstine, and R. A. Gatti (2007)
Hum. Mol. Genet. 16, 2154-2164
   Abstract »    Full Text »    PDF »
Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.
N. Fersht, D. Hermand, J. Hayles, and P. Nurse (2007)
Nucleic Acids Res. 35, 5323-5337
   Abstract »    Full Text »    PDF »
Tumor Suppression and Circadian Function.
M. Chen-Goodspeed and Cheng Chi Lee (2007)
J Biol Rhythms 22, 291-298
   Abstract »    PDF »
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
K. Morita, T. Miyamoto, N. Fujita, Y. Kubota, K. Ito, K. Takubo, K. Miyamoto, K. Ninomiya, T. Suzuki, R. Iwasaki, et al. (2007)
J. Exp. Med. 204, 1613-1623
   Abstract »    Full Text »    PDF »
Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia.
M. F. Lavin, N. Gueven, S. Bottle, and R. A. Gatti (2007)
Br. Med. Bull.
   Abstract »    Full Text »    PDF »
Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players.
N. Rahman and R. H. Scott (2007)
Hum. Mol. Genet. 16, R60-R66
   Abstract »    Full Text »    PDF »
Slow-Flow Vascular Malformations.
G. A. Wirth and M. J. Sundine (2007)
Clinical Pediatrics 46, 109-120
   PDF »
Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk.
K. Einarsdottir, K. Humphreys, C. Bonnard, Y. Li, Y. Li, K. S. Chia, E. T. Liu, P. Hall, J. Liu, and S. Wedren (2007)
Hum. Mol. Genet. 16, 154-164
   Abstract »    Full Text »    PDF »
Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia.
L.I. Wallis, P.D. Griffiths, S.J. Ritchie, C.A.J. Romanowski, G. Darwent, and I.D. Wilkinson (2007)
AJNR Am. J. Neuroradiol. 28, 79-83
   Abstract »    Full Text »    PDF »
Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes.
K. Ito, K. Takubo, F. Arai, H. Satoh, S. Matsuoka, M. Ohmura, K. Naka, M. Azuma, K. Miyamoto, K. Hosokawa, et al. (2007)
J. Immunol. 178, 103-110
   Abstract »    Full Text »    PDF »
Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis.
N. Rasheed, X. Wang, Q.-T. Niu, J. Yeh, and B. Li (2006)
Hum. Mol. Genet. 15, 1938-1948
   Abstract »    Full Text »    PDF »
Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals.
P. E. Cohen, S. E. Pollack, and J. W. Pollard (2006)
Endocr. Rev. 27, 398-426
   Abstract »    Full Text »    PDF »
BRCC36 Is Essential for Ionizing Radiation-Induced BRCA1 Phosphorylation and Nuclear Foci Formation..
X. Chen, C. A. Arciero, C. Wang, D. Broccoli, and A. K. Godwin (2006)
Cancer Res. 66, 5039-5046
   Abstract »    Full Text »    PDF »
DNA damage responses and their many interactions with the replication fork.
P. R. Andreassen, G. P.H. Ho, and A. D. D'Andrea (2006)
Carcinogenesis 27, 883-892
   Abstract »    Full Text »    PDF »
Active role for nibrin in the kinetics of atm activation..
K. Cerosaletti, J. Wright, and P. Concannon (2006)
Mol. Cell. Biol. 26, 1691-1699
   Abstract »    Full Text »    PDF »
Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila.
C. R. Preston, C. C. Flores, and W. R. Engels (2006)
Genetics 172, 1055-1068
   Abstract »    Full Text »    PDF »
Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation.
Q. Pan-Hammarstrom, A. Lahdesmaki, Y. Zhao, L. Du, Z. Zhao, S. Wen, V. L. Ruiz-Perez, D. K. Dunn-Walters, J. A. Goodship, and L. Hammarstrom (2006)
J. Exp. Med. 203, 99-110
   Abstract »    Full Text »    PDF »
DNA Replication Stress-induced Phosphorylation of Cyclic AMP Response Element-binding Protein Mediated by ATM.
G. E. Dodson and R. S. Tibbetts (2006)
J. Biol. Chem. 281, 1692-1697
   Abstract »    Full Text »    PDF »
Evidence of Meiotic Crossover Control in Saccharomyces cerevisiae Through Mec1-Mediated Phosphorylation of Replication Protein A.
A. J. Bartrand, D. Iyasu, S. M. Marinco, and G. S. Brush (2006)
Genetics 172, 27-39
   Abstract »    Full Text »    PDF »
Tumor suppressor genetics.
S. R. Payne and C. J. Kemp (2005)
Carcinogenesis 26, 2031-2045
   Abstract »    Full Text »    PDF »
Impaired hepatocyte survival and liver regeneration in Atm-deficient mice.
S. Lu, K. C. Shen, Y. Wang, S.C. Brooks, and Y. A. Wang (2005)
Hum. Mol. Genet. 14, 3019-3025
   Abstract »    Full Text »    PDF »
A role for PKC{zeta} in potentiation of the topoisomerase II activity and etoposide cytotoxicity by wortmannin.
C. Reis, N. Giocanti, C. Hennequin, F. Megnin-Chanet, M. Fernet, R. Filomenko, A. Bettaieb, E. Solary, and V. Favaudon (2005)
Mol. Cancer Ther. 4, 1457-1464
   Abstract »    Full Text »    PDF »
A Quantitative Measurement of the Human Somatic Mutation Rate.
D. J. Araten, D. W. Golde, R. H. Zhang, H. T. Thaler, L. Gargiulo, R. Notaro, and L. Luzzatto (2005)
Cancer Res. 65, 8111-8117
   Abstract »    Full Text »    PDF »
Restarting the Cell Cycle When the Checkpoint Comes to a Halt.
M. A.T.M. van Vugt, A. Bras, and R. H. Medema (2005)
Cancer Res. 65, 7037-7040
   Abstract »    Full Text »    PDF »
Prediction of Radiation Sensitivity Using a Gene Expression Classifier.
J. F. Torres-Roca, S. Eschrich, H. Zhao, G. Bloom, J. Sung, S. McCarthy, A. B. Cantor, A. Scuto, C. Li, S. Zhang, et al. (2005)
Cancer Res. 65, 7169-7176
   Abstract »    Full Text »    PDF »
Cancer Risks and Mortality in Heterozygous ATM Mutation Carriers.
D. Thompson, S. Duedal, J. Kirner, L. McGuffog, J. Last, A. Reiman, P. Byrd, M. Taylor, and D. F. Easton (2005)
J Natl Cancer Inst 97, 813-822
   Abstract »    Full Text »    PDF »
Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair.
J. R. Alt, A. Bouska, M. R. Fernandez, R. L. Cerny, H. Xiao, and C. M. Eischen (2005)
J. Biol. Chem. 280, 18771-18781
   Abstract »    Full Text »    PDF »
Genetic Polymorphisms of Ataxia Telangiectasia Mutated and Breast Cancer Risk.
K.-M. Lee, J.-Y. Choi, S. K. Park, H.-W. Chung, B. Ahn, K.-Y. Yoo, W. Han, D.-Y. Noh, S.-H. Ahn, H. Kim, et al. (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 821-825
   Abstract »    Full Text »    PDF »
Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.
F.-M. Boisvert, U. Dery, J.-Y. Masson, and S. Richard (2005)
Genes & Dev. 19, 671-676
   Abstract »    Full Text »    PDF »
Loss of Neuronal Cell Cycle Control in Ataxia-Telangiectasia: A Unified Disease Mechanism.
Y. Yang and K. Herrup (2005)
J. Neurosci. 25, 2522-2529
   Abstract »    Full Text »    PDF »
Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-Regulation of ATM.
Y. Peng, R. G. Woods, H. Beamish, R. Ye, S. P. Lees-Miller, M. F. Lavin, and J. S. Bedford (2005)
Cancer Res. 65, 1670-1677
   Abstract »    Full Text »    PDF »
Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.
M. Fernet, M. Gribaa, M. A.M. Salih, M. Z. Seidahmed, J. Hall, and M. Koenig (2005)
Hum. Mol. Genet. 14, 307-318
   Abstract »    Full Text »    PDF »
The ATM-dependent DNA Damage Signaling Pathway.
R. KITAGAWA and M.B. KASTAN (2005)
Cold Spring Harb Symp Quant Biol 70, 99-109
   Abstract »    PDF »
Interaction of 14-3-3 protein with Chk1 affects localization and checkpoint function.
S. Dunaway, H.-Y. Liu, and N. C. Walworth (2005)
J. Cell Sci. 118, 39-50
   Abstract »    Full Text »    PDF »
A Tel1/MRX-Dependent Checkpoint Inhibits the Metaphase-to-Anaphase Transition after UV Irradiation in the Absence of Mec1.
M. Clerici, V. Baldo, D. Mantiero, F. Lottersberger, G. Lucchini, and M. P. Longhese (2004)
Mol. Cell. Biol. 24, 10126-10144
   Abstract »    Full Text »    PDF »
Increased Genome Instability and Telomere Length in the elg1-Deficient Saccharomyces cerevisiae Mutant Are Regulated by S-Phase Checkpoints.
S. Banerjee and K. Myung (2004)
Eukaryot. Cell 3, 1557-1566
   Abstract »    Full Text »    PDF »
Ataxia-Telangiectasia Mutated Gene Controls Insulin-Like Growth Factor I Receptor Gene Expression in a Deoxyribonucleic Acid Damage Response Pathway via Mechanisms Involving Zinc-Finger Transcription Factors Sp1 and WT1.
L. Shahrabani-Gargir, T. K. Pandita, and H. Werner (2004)
Endocrinology 145, 5679-5687
   Abstract »    Full Text »    PDF »
Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae.
K. Myung, S. Smith, and R. D. Kolodner (2004)
PNAS 101, 15980-15985
   Abstract »    Full Text »    PDF »
ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions.
B. Reina-San-Martin, H. T. Chen, A. Nussenzweig, and M. C. Nussenzweig (2004)
J. Exp. Med. 200, 1103-1110
   Abstract »    Full Text »    PDF »
A new locus for a childhood onset, slowly progressive autosomal recessive spinocerebellar ataxia maps to chromosome 11p15.
G J Breedveld, B van Wetten, G D te Raa, E Brusse, J C van Swieten, B A Oostra, and J A Maat-Kievit (2004)
J. Med. Genet. 41, 858-866
   Full Text »    PDF »
MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
D. Delia, M. Piane, G. Buscemi, C. Savio, S. Palmeri, P. Lulli, L. Carlessi, E. Fontanella, and L. Chessa (2004)
Hum. Mol. Genet. 13, 2155-2163
   Abstract »    Full Text »    PDF »
Independent Roles for Nibrin and Mre11-Rad50 in the Activation and Function of Atm.
K. Cerosaletti and P. Concannon (2004)
J. Biol. Chem. 279, 38813-38819
   Abstract »    Full Text »    PDF »
Cancer chemoprevention by the antioxidant tempol in Atm-deficient mice.
R. Schubert, L. Erker, C. Barlow, H. Yakushiji, D. Larson, A. Russo, J. B. Mitchell, and A. Wynshaw-Boris (2004)
Hum. Mol. Genet. 13, 1793-1802
   Abstract »    Full Text »    PDF »
p53 Localization at Centrosomes during Mitosis and Postmitotic Checkpoint Are ATM-dependent and Require Serine 15 Phosphorylation.
A. Tritarelli, E. Oricchio, M. Ciciarello, R. Mangiacasale, A. Palena, P. Lavia, S. Soddu, and E. Cundari (2004)
Mol. Biol. Cell 15, 3751-3757
   Abstract »    Full Text »    PDF »
DNA Stimulates Mec1-mediated Phosphorylation of Replication Protein A.
A. J. Bartrand, D. Iyasu, and G. S. Brush (2004)
J. Biol. Chem. 279, 26762-26767
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of the Catalytic Domain of Zebrafish Homologue of the Ataxia-Telangiectasia Mutated Gene.
R. Garg, C.-D. Geng, J. L. Miller, S. Callens, X. Tang, B. Appel, and B. Xu (2004)
Mol. Cancer Res. 2, 348-353
   Abstract »    Full Text »    PDF »
The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation.
E. Baroni, V. Viscardi, H. Cartagena-Lirola, G. Lucchini, and M. P. Longhese (2004)
Mol. Cell. Biol. 24, 4151-4165
   Abstract »    Full Text »    PDF »
The Molecular Pathology of Primary Immunodeficiencies.
M. S. Lim and K. S.J. Elenitoba-Johnson (2004)
J. Mol. Diagn. 6, 59-83
   Full Text »    PDF »
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage.
K. E. Rieger, W.-J. Hong, V. G. Tusher, J. Tang, R. Tibshirani, and G. Chu (2004)
PNAS 101, 6635-6640
   Abstract »    Full Text »    PDF »
Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.
Y. Shi, S. L. Venkataraman, G. E. Dodson, A. M. Mabb, S. LeBlanc, and R. S. Tibbetts (2004)
PNAS 101, 5898-5903
   Abstract »    Full Text »    PDF »
Predictive Models for Breast Cancer Susceptibility from Multiple Single Nucleotide Polymorphisms.
J. Listgarten, S. Damaraju, B. Poulin, L. Cook, J. Dufour, A. Driga, J. Mackey, D. Wishart, R. Greiner, and B. Zanke (2004)
Clin. Cancer Res. 10, 2725-2737
   Abstract »    Full Text »    PDF »
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation.
T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Lobrich, and P. A. Jeggo (2004)
Cancer Res. 64, 2390-2396
   Abstract »    Full Text »    PDF »
Frequency and phenotypic spectrum of ataxia with oculomotor apraxia 2: a clinical and genetic study in 18 patients.
I. Le Ber, N. Bouslam, S. Rivaud-Pechoux, J. Guimaraes, A. Benomar, C. Chamayou, C. Goizet, M.-C. Moreira, S. Klur, M. Yahyaoui, et al. (2004)
Brain 127, 759-767
   Abstract »    Full Text »    PDF »
The Meiosis-specific Protein Kinase Ime2 Directs Phosphorylation of Replication Protein A.
D. M. Clifford, S. M. Marinco, and G. S. Brush (2004)
J. Biol. Chem. 279, 6163-6170
   Abstract »    Full Text »    PDF »
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
A. Ali, J. Zhang, S. Bao, I. Liu, D. Otterness, N. M. Dean, R. T. Abraham, and X.-F. Wang (2004)
Genes & Dev. 18, 249-254
   Abstract »    Full Text »    PDF »
RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult.
E. E. Bosco, C. N. Mayhew, R. F. Hennigan, J. Sage, T. Jacks, and E. S. Knudsen (2004)
Nucleic Acids Res. 32, 25-34
   Abstract »    Full Text »    PDF »
Ataxia-Telangiectasia-Mutated (ATM) Gene in Head and Neck Squamous Cell Carcinoma: Promoter Hypermethylation with Clinical Correlation in 100 Cases.
L. Ai, Q. N. Vo, C. Zuo, L. Li, W. Ling, J. Y. Suen, E. Hanna, K. D. Brown, and C.-Y. Fan (2004)
Cancer Epidemiol. Biomarkers Prev. 13, 150-156
   Abstract »    Full Text »    PDF »
Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease.
M. Takagi, R. Tsuchida, K. Oguchi, T. Shigeta, S. Nakada, K. Shimizu, M. Ohki, D. Delia, L. Chessa, Y. Taya, et al. (2004)
Blood 103, 283-290
   Abstract »    Full Text »    PDF »
ATMHaplotypes and Cellular Response to DNA Damage: Association with Breast Cancer Risk and Clinical Radiosensitivity.
S. Angele, P. Romestaing, N. Moullan, M. Vuillaume, B. Chapot, M. Friesen, W. Jongmans, D. G. Cox, P. Pisani, J.-P. Gerard, et al. (2003)
Cancer Res. 63, 8717-8725
   Abstract »    Full Text »    PDF »
Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice.
P. Chen, C. Peng, J. Luff, K. Spring, D. Watters, S. Bottle, S. Furuya, and M. F. Lavin (2003)
J. Neurosci. 23, 11453-11460
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)